ModCRE DB

Transcription factor

A0A0A0MSL2 - IKZF2

IKAROS family zinc finger 2

Homo sapiens (Human) · Unreviewed (UniProtKB/TrEMBL) · 409 aa

13 Generated PWM 12 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)2
MotifPredictionSourceDNA bindingSupportLogoActions
MA1508.1 NN 70-40% JASPAR GAAACAGGAAGT 52.3% identity Open · Scan
M08320_2.00 NN 70-40% CisBP TTCCCTGCC 50.2% identity Open · Scan
ModCRE11
MotifPredictionSourceDNA bindingSupportLogoActions
TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:63:146_2i13_A_1 ModCRE Homology model AGCTAAGGCCTACTTT Region 63-146 · 1 3D model Open · Scan
TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:63:147_5v3j_E_1 ModCRE Homology model TGGGTTAGGGCCCACTA Region 63-147 · 1 3D model Open · Scan
TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:63:147_5v3m_C_1 ModCRE Homology model GCCACCAGGCCCCAGTT Region 63-147 · 1 3D model Open · Scan
TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:63:147_5wjq_D_1 ModCRE Homology model AGGTGAGGCCCAGCGTT Region 63-147 · 1 3D model Open · Scan
TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:69:145_1a1h_A_1 ModCRE Homology model CTCCCGCCAC Region 69-145 · 1 3D model Open · Scan
a0a0a0msl2.af3.0 ModCRE AlphaFold3 model TTTAGGTGCCCCCGGGGGG AlphaFold3 model · ModCRE PWM Open · Scan
a0a0a0msl2.af3.1 ModCRE AlphaFold3 model TTTAGGTGCCCCCGGGGGG AlphaFold3 model · ModCRE PWM Open · Scan
a0a0a0msl2.af3.2 ModCRE AlphaFold3 model TTTACCTGCCCCTGGGCA AlphaFold3 model · ModCRE PWM Open · Scan
a0a0a0msl2.af3.3 ModCRE AlphaFold3 model TTTTTTCCCCCCCGGCGG AlphaFold3 model · ModCRE PWM Open · Scan
a0a0a0msl2.af3.4 ModCRE AlphaFold3 model TTAGTTCCCCCCGGGGCCGGGGG AlphaFold3 model · ModCRE PWM Open · Scan
a0a0a0msl2.af3.5 ModCRE AlphaFold3 model TTTAAACCCCCCTGGGCA AlphaFold3 model · ModCRE PWM Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 409 aa
63-150

Region 63-150 5 PWM

Residues
88 aa
Domains
PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type
3D models
6 active PDBs · 6 summary rows
Templates
1A1H, 1LLM, 2I13, 5V3J, 5V3M, 5WJQ
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
12 active PDB models 6 summary rows
Region 63-1506 models · 6 summary rows
Actions
Predicted = Low DIMER_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:97:150_1llm_C_1 1llm 97-150 View model · PDB
Predicted = Low TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:63:146_2i13_A_1 2i13 63-146 View model · PDB
Predicted = Low TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:63:147_5v3j_E_1 5v3j 63-147 View model · PDB
Predicted = Low TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:63:147_5v3m_C_1 5v3m 63-147 View model · PDB
Predicted = Low TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:63:147_5wjq_D_1 5wjq 63-147 View model · PDB
Predicted = Low TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:69:145_1a1h_A_1 1a1h 69-145 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
1 2i13 62:151 63 146 P:A · DNA:C,D 45.2% / 64.3% 55 View · PDB TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:63:146_2i13_A_1
2 5wjq 62:151 63 147 P:D · DNA:A,B 42.4% / 63.5% 30 View · PDB TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:63:147_5wjq_D_1
3 5v3m 62:151 63 147 P:C · DNA:A,B 42.4% / 63.5% 30 View · PDB TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:63:147_5v3m_C_1
4 5v3j 62:151 63 147 P:E · DNA:A,B 42.4% / 63.5% 30 View · PDB TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:63:147_5v3j_E_1
5 1a1h 62:151 69 145 P:A · DNA:B,C 41.8% / 59.5% 90 View · PDB TFS_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:69:145_1a1h_A_1
1 1llm 62:151 97,97 150,150 P:C,D · DNA:A,B 38.9% / 55.6% 62,63 View · PDB DIMER_tr_A0A0A0MSL2_A0A0A0MSL2_HUMAN:97:150_1llm_C_1
Full sequence / unlocalized models6 models
SourceModelTemplateResidues modeledActions
Predicted = Lowa0a0a0msl2.af3.0-Full sequence / not localizedView model · PDB
Predicted = Lowa0a0a0msl2.af3.1-Full sequence / not localizedView model · PDB
Predicted = Lowa0a0a0msl2.af3.2-Full sequence / not localizedView model · PDB
Predicted = Lowa0a0a0msl2.af3.3-Full sequence / not localizedView model · PDB
Predicted = Lowa0a0a0msl2.af3.4-Full sequence / not localizedView model · PDB
Predicted = Lowa0a0a0msl2.af3.5-Full sequence / not localizedView model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
71-93PF00096Zinc finger, C2H2 typeoverlaps 63-150
99-121PF00096Zinc finger, C2H2 typeoverlaps 63-150
127-150PF00096Zinc finger, C2H2 typeoverlaps 63-150