Transcription factor

A0A1B0GV02 - ZEB2

Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (Zinc finger homeobox protein 1b)

Homo sapiens (Human) · Unreviewed (UniProtKB/TrEMBL) · 1239 aa

43 Generated PWM 32 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)31

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
M07842_2.00	NN 70-40%	CisBP	CTCACCTG	56.2% identity		Open · Scan
M08860_2.00	NN 70-40%	CisBP	TCTTATAAGGGCACTAATCCCATT	55.8% identity		Open · Scan
M08335_2.00	NN 70-40%	CisBP	AGTCGTTGTCTG	53.6% identity		Open · Scan
M06179_2.00	NN 70-40%	CisBP	TAAGCCTATAGA	53.4% identity		Open · Scan
MA1587.1	NN 70-40%	JASPAR	CCTCGACCTCCTGA	53.3% identity		Open · Scan
M00764_2.00	NN 70-40%	CisBP	GTCTACAC	53.0% identity		Open · Scan
M07578_2.00	NN 70-40%	CisBP	CAACTCTCC	53.0% identity		Open · Scan
M07753_2.00	NN 70-40%	CisBP	TGCATTCCTTGGCTTGTG	52.7% identity		Open · Scan
M08311_2.00	NN 70-40%	CisBP	CTGGAACAGAAGGGGCGA	52.2% identity		Open · Scan
M00782_2.00	NN 70-40%	CisBP	AGTGTGCGCTA	52.1% identity		Open · Scan
M07684_2.00	NN 70-40%	CisBP	CCTGTTCTTGACTTT	52.1% identity		Open · Scan
M07691_2.00	NN 70-40%	CisBP	CCTGCAGCCACCTTGGCCTTG	51.5% identity		Open · Scan
M08390_2.00	NN 70-40%	CisBP	GCTTTGTTGACTCAC	51.5% identity		Open · Scan
M00960_2.00	NN 70-40%	CisBP	TGCATCCC	51.4% identity		Open · Scan
M07601_2.00	NN 70-40%	CisBP	CAGATGCCGGCACCATGCTTC	51.4% identity		Open · Scan
M08325_2.00	NN 70-40%	CisBP	TTTTTTTTT	51.3% identity		Open · Scan
M08347_2.00	NN 70-40%	CisBP	GCCCTGGGCAGC	51.3% identity		Open · Scan
M08300_2.00	NN 70-40%	CisBP	CTGCCCAATTCAT	51.2% identity		Open · Scan
M07667_2.00	NN 70-40%	CisBP	CCGCACAGGCCCCCGGGCCCC	50.7% identity		Open · Scan
M08252_2.00	NN 70-40%	CisBP	CCGGCTCCAGCACCC	50.7% identity		Open · Scan
M04475_2.00	NN 70-40%	CisBP	GATGCACGTACCGTGCCTCA	50.6% identity		Open · Scan
M04650_2.00	NN 70-40%	CisBP	GCATAACTGCCCCGCTGCC	50.6% identity		Open · Scan
M07590_2.00	NN 70-40%	CisBP	TTTTTTTCTTTTATTTTTTTTTTTTTTTTTTTT	50.6% identity		Open · Scan
M01883_2.00	NN 70-40%	CisBP	TGCCCCTGA	50.0% identity		Open · Scan
M07567_2.00	NN 70-40%	CisBP	CCACTCCACTCA	50.0% identity		Open · Scan
M07600_2.00	NN 70-40%	CisBP	GCATTAGC	50.0% identity		Open · Scan
M07703_2.00	NN 70-40%	CisBP	CCGACGG	50.0% identity		Open · Scan
M08373_2.00	NN 70-40%	CisBP	CCCCCTGGCTCTTCCTCT	50.0% identity		Open · Scan
M08395_2.00	NN 70-40%	CisBP	GCTGCCTACTCTTCC	50.0% identity		Open · Scan
MA0038.1	NN 70-40%	JASPAR	CAAATCACTG	50.0% identity		Open · Scan
MA0038.2	NN 70-40%	JASPAR	CAAATCACTGCA	50.0% identity		Open · Scan

ModCRE12

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
DIMER_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:684:721_1au7_B_1	ModCRE	Homology model	TTTTTAACTTCATCGCTTTCAAGA	Region 684-721 · 1 3D model		Open · Scan
DIMER_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:684:721_1hf0_B_1	ModCRE	Homology model	CTTAAAAGGAAATCTAATTAAG	Region 684-721 · 1 3D model		Open · Scan
DIMER_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:684:721_5wc9_A_1	ModCRE	Homology model	CCCCTGGGGCCTGTGATC	Region 684-721 · 1 3D model		Open · Scan
TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:280:357_5und_A_1	ModCRE	Homology model	CGCAGCCCCCCAACC	Region 280-357 · 1 3D model		Open · Scan
TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:280:357_5yeh_A_1	ModCRE	Homology model	TAACCCCTGCTTCCG	Region 280-357 · 1 3D model		Open · Scan
TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:282:357_5yeg_A_1	ModCRE	Homology model	GAAAAGGCCCCGGGG	Region 282-357 · 1 3D model		Open · Scan
a0a1b0gv02.af3.0	ModCRE	AlphaFold3 model	GCGCCGCGGGCCCATTTCCCCCCGGGGTCA	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1b0gv02.af3.1	ModCRE	AlphaFold3 model	CGAAAAAAGAATTCAAGGTTTTTAAAGTTG	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1b0gv02.af3.2	ModCRE	AlphaFold3 model	TTTAAAATGATTTTTTTTAAAAATGTAATT	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1b0gv02.af3.3	ModCRE	AlphaFold3 model	GGTACTGTCCAGGTGTCTACTTTACCCG	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1b0gv02.af3.4	ModCRE	AlphaFold3 model	GCGCCGCGGGCCCATTTCCCCCCGGGGTCA	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1b0gv02.af3.5	ModCRE	AlphaFold3 model	GGGGGGGGCCGGCCCCCCGCCCGGGCCCC	AlphaFold3 model · ModCRE PWM		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 1239 aa

280-357

684-721

1024-1098

Region 280-357 3 PWM

Residues

78 aa

Domains

PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type

3D models

5 active PDBs

Templates

5UND, 5YEF, 5YEG, 5YEH

Sources

Predicted = Low

Scan this region Show models

Region 684-721 3 PWM

Residues

38 aa

Domains

No overlapping PFAM annotation recorded

3D models

3 active PDBs

Templates

1AU7, 1HF0, 5WC9

Sources

Predicted = Low

Scan this region Show models

Region 1024-1098 0 PWM

Residues

75 aa

Domains

PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type

3D models

6 active PDBs · 6 summary rows

Templates

1A1I, 1A1J, 1A1K, 1JK1, 1JK2, 1LLM

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

32 active PDB models 6 summary rows

Region 280-3575 models

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:280:357_5und_A_1	5und	280-357	View model · PDB
Predicted = Low	TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:280:357_5yef_B_1	5yef	280-357	View model · PDB
Predicted = Low	TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:280:357_5yef_J_1	5yef	280-357	View model · PDB
Predicted = Low	TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:280:357_5yeh_A_1	5yeh	280-357	View model · PDB
Predicted = Low	TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:282:357_5yeg_A_1	5yeg	282-357	View model · PDB

Region 684-7213 models

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:684:721_1au7_B_1	1au7	684-721	View model · PDB
Predicted = Low	DIMER_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:684:721_1hf0_B_1	1hf0	684-721	View model · PDB
Predicted = Low	DIMER_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:684:721_5wc9_A_1	5wc9	684-721	View model · PDB

Region 1024-10986 models · 6 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:1050:1098_1llm_C_1	1llm	1050-1098	View model · PDB
Predicted = Low	TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:1024:1098_1a1i_A_1	1a1i	1024-1098	View model · PDB
Predicted = Low	TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:1024:1098_1a1j_A_1	1a1j	1024-1098	View model · PDB
Predicted = Low	TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:1024:1098_1a1k_A_1	1a1k	1024-1098	View model · PDB
Predicted = Low	TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:1024:1098_1jk1_A_1	1jk1	1024-1098	View model · PDB
Predicted = Low	TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:1024:1098_1jk2_A_1	1jk2	1024-1098	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
1	1a1j	1007:1104	1024	1098	P:A · DNA:B,C	45.5% / 63.6%	89	View · PDB TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:1024:1098_1a1j_A_1
2	1a1k	1007:1104	1024	1098	P:A · DNA:B,C	45.5% / 63.6%	88	View · PDB TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:1024:1098_1a1k_A_1
3	1a1i	1007:1104	1024	1098	P:A · DNA:B,C	45.5% / 63.6%	88	View · PDB TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:1024:1098_1a1i_A_1
4	1jk2	1007:1104	1024	1098	P:A · DNA:B,C	45.5% / 63.6%	88	View · PDB TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:1024:1098_1jk2_A_1
5	1jk1	1007:1104	1024	1098	P:A · DNA:B,C	45.5% / 63.6%	88	View · PDB TFS_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:1024:1098_1jk1_A_1
1	1llm	1007:1104	1050,1050	1098,1098	P:C,D · DNA:A,B	44.9% / 63.3%	56,57	View · PDB DIMER_tr_A0A1B0GV02_A0A1B0GV02_HUMAN:1050:1098_1llm_C_1

Full sequence / unlocalized models18 models

Source	Model	Template	Residues modeled	Actions
Predicted = Low	a0a1b0gv02.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02_dimer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02_dimer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02_dimer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02_dimer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02_dimer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02_dimer.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02_monomer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02_monomer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02_monomer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02_monomer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02_monomer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gv02_monomer.af3.5	-	Full sequence / not localized	View model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
211-262	PF05605	Drought induced 19 protein (Di19), zinc-binding	No overlap with loaded model regions
282-304	PF00096	Zinc finger, C2H2 type	overlaps 280-357
335-355	PF00096	Zinc finger, C2H2 type	overlaps 280-357
1024-1046	PF00096	Zinc finger, C2H2 type	overlaps 1024-1098
1080-1100	PF00096	Zinc finger, C2H2 type	overlaps 1024-1098