Transcription factor

A0A1B0GWH4 - HSFX3

Heat shock transcription factor, X-linked member 3

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 333 aa

16 Generated PWM 27 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)1

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
M05511_2.00	NN 70-40%	CisBP	ATTCGAACGTTTCGAACGC	57.3% identity		Open · Scan

ModCRE15

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:148_5d8l_D_1	ModCRE	Homology model	ACCGTTTGGAACC	Region 82-148 · 1 3D model		Open · Scan
TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:148_7dcu_A_1	ModCRE	Homology model	ACCTTTGGGAACGGGCCGC	Region 82-148 · 1 3D model		Open · Scan
TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:148_7dcu_B_1	ModCRE	Homology model	GGGTTCCATACGGT	Region 82-148 · 1 3D model		Open · Scan
TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:148_7dcu_C_1	ModCRE	Homology model	GTAACAGTTTCCAGC	Region 82-148 · 1 3D model		Open · Scan
TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:182_5d5v_D_1	ModCRE	Homology model	CAGAAACAGCGC	Region 82-182 · 1 3D model		Open · Scan
TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:182_5d8l_B_1	ModCRE	Homology model	GCTCCTAGAACCTTTTA	Region 82-182 · 1 3D model		Open · Scan
TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:182_7dcj_B_1	ModCRE	Homology model	CGCCAGTTTCTA	Region 82-182 · 1 3D model		Open · Scan
TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:83:182_5d5x_B_1	ModCRE	Homology model	GGTCCTGGGCCCC	Region 83-182 · 1 3D model		Open · Scan
TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:83:182_5d5x_E_1	ModCRE	Homology model	CCCCTAGACACTG	Region 83-182 · 1 3D model		Open · Scan
a0a1b0gwh4.af3.0	ModCRE	AlphaFold3 model	TGGGCTCCTAAAAAATTAAAAAC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1b0gwh4.af3.1	ModCRE	AlphaFold3 model	TCGGGGCCTAGAAAATTGCAAAC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1b0gwh4.af3.2	ModCRE	AlphaFold3 model	TGGGGTCCTAGAAAATTAGACACC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1b0gwh4.af3.3	ModCRE	AlphaFold3 model	ACGGGGCCTAAAAAATTGGCCAC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1b0gwh4.af3.4	ModCRE	AlphaFold3 model	TGGGGGCCTAGAAAATGAAACCCG	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1b0gwh4.af3.5	ModCRE	AlphaFold3 model	TGGGGTCCTAAAAAATTAAAAAC	AlphaFold3 model · ModCRE PWM		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 333 aa

82-182

Region 82-182 9 PWM

Residues

101 aa

Domains

PF00447 · HSF-type DNA-binding

3D models

9 active PDBs · 5 summary rows

Templates

5D5V, 5D5X, 5D8L, 7DCJ, 7DCU

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

27 active PDB models 5 summary rows

Region 82-1829 models · 5 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:148_5d8l_D_1	5d8l	82-148	View model · PDB
Predicted = Low	TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:148_7dcu_A_1	7dcu	82-148	View model · PDB
Predicted = Low	TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:148_7dcu_B_1	7dcu	82-148	View model · PDB
Predicted = Low	TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:148_7dcu_C_1	7dcu	82-148	View model · PDB
Predicted = Low	TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:182_5d5v_D_1	5d5v	82-182	View model · PDB
Predicted = Low	TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:182_5d8l_B_1	5d8l	82-182	View model · PDB
Predicted = Low	TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:182_7dcj_B_1	7dcj	82-182	View model · PDB
Predicted = Low	TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:83:182_5d5x_B_1	5d5x	83-182	View model · PDB
Predicted = Low	TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:83:182_5d5x_E_1	5d5x	83-182	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
2	7dcu	82:182	82	148	P:B · DNA:D,E	39.1% / 68.1%	60	View · PDB TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:148_7dcu_B_1
4	7dcu	82:182	82	148	P:C · DNA:D,E	39.1% / 68.1%	67	View · PDB TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:148_7dcu_C_1
5	7dcu	82:182	82	148	P:A · DNA:D,E	39.1% / 68.1%	61	View · PDB TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:148_7dcu_A_1
3	7dcj	82:182	82	182	P:B · DNA:C,D	35.5% / 55.1%	85	View · PDB TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:182_7dcj_B_1
1	5d8l	82:182	82	182	P:B · DNA:A,C	34.6% / 61.7%	90	View · PDB TFS_sp_A0A1B0GWH4_HSFX3_HUMAN:82:182_5d8l_B_1

Full sequence / unlocalized models18 models

Source	Model	Template	Residues modeled	Actions
Predicted = Low	a0a1b0gwh4.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4_dimer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4_dimer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4_dimer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4_dimer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4_dimer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4_dimer.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4_monomer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4_monomer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4_monomer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4_monomer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4_monomer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1b0gwh4_monomer.af3.5	-	Full sequence / not localized	View model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
83-182	PF00447	HSF-type DNA-binding	overlaps 82-182