Transcription factor

A0A1W2PPF3 - DUXB

Double homeobox protein B

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 345 aa

26 Generated PWM 37 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)1

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
MA0621.1	NN 70-40%	JASPAR	AATTAATTAGT	50.0% identity		Open · Scan

ModCRE25

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:103:155_6a8r_B_1	ModCRE	Homology model	AAATTAGGGA	Region 103-155 · 1 3D model		Open · Scan
DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:103:159_3a01_B_1	ModCRE	Homology model	AAATAAATTGATGAGAA	Region 103-159 · 1 3D model		Open · Scan
DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:103:160_1fjl_A_1	ModCRE	Homology model	TGAATTAAATGAA	Region 103-160 · 1 3D model		Open · Scan
DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:106:155_5z2t_D_1	ModCRE	Homology model	TAAATTTAATTAA	Region 106-155 · 1 3D model		Open · Scan
DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:106:155_6dfy_C_1	ModCRE	Homology model	AATTTTATTGG	Region 106-155 · 1 3D model		Open · Scan
DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:17:72_1b72_B_1	ModCRE	Homology model	TTAAATTATTTATGAAAGG	Region 17-72 · 1 3D model		Open · Scan
DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:17:73_5hod_A_1	ModCRE	Homology model	TCAATAATTGGGAATATG	Region 17-73 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPF3_DUXB_HUMAN:103:159_3a01_B_1	ModCRE	Homology model	AAATTAATTGGGGGGAA	Region 103-159 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPF3_DUXB_HUMAN:106:160_3lnq_A_1	ModCRE	Homology model	AAAACCAATGTGGT	Region 106-160 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_5z6z_A_1	ModCRE	Homology model	ATATTAAACTTATAACTTT	Region 17-155 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_5zfw_A_1	ModCRE	Homology model	ATATTAAATATTTTACTTC	Region 17-155 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_5zfy_A_1	ModCRE	Homology model	AGAGTTAAATATTTAAAAT	Region 17-155 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_5zfz_A_1	ModCRE	Homology model	ATTTTAATTTTTTTACACT	Region 17-155 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_6e8c_A_1	ModCRE	Homology model	AACTAAAATGATTAAAA	Region 17-155 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_6u81_A_1	ModCRE	Homology model	TTTTTTAGTT	Region 17-155 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_6u82_A_1	ModCRE	Homology model	ATTTTTAGTTC	Region 17-155 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:72_5zjr_B_1	ModCRE	Homology model	TTGGGTCATAAATG	Region 17-72 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:72_5zjt_B_1	ModCRE	Homology model	CTAATTCATTATGG	Region 17-72 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:73_5hod_A_1	ModCRE	Homology model	CAGATTCCCATTTATTGA	Region 17-73 · 1 3D model		Open · Scan
a0a1w2ppf3.af3.0	ModCRE	AlphaFold3 model	AAAATAATTGAAACACGTCCGAAGGT	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2ppf3.af3.1	ModCRE	AlphaFold3 model	TAAATAATTTAATTTTGATAAGATGG	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2ppf3.af3.2	ModCRE	AlphaFold3 model	TAAATATTTAGAACGTTTTACCTT	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2ppf3.af3.3	ModCRE	AlphaFold3 model	AAGCCAAAAATTATTAATTTATTTC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2ppf3.af3.4	ModCRE	AlphaFold3 model	TAAATATTTTAAAGTTTTGTCGATT	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2ppf3.af3.5	ModCRE	AlphaFold3 model	AAAATAATTGAAACACGTCCGAAGGT	AlphaFold3 model · ModCRE PWM		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 345 aa

17-164

Region 17-164 19 PWM

Residues

148 aa

Domains

PF00046 · Homeodomain PF00046 · Homeodomain

3D models

19 active PDBs · 10 summary rows

Templates

1B72, 1FJL, 3A01, 3LNQ, 5HOD, 5Z2T, 5Z6Z, 5ZFW, ...

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

37 active PDB models 10 summary rows

Region 17-16419 models · 10 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:103:155_6a8r_B_1	6a8r	103-155	View model · PDB
Predicted = Low	DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:103:159_3a01_B_1	3a01	103-159	View model · PDB
Predicted = Low	DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:103:160_1fjl_A_1	1fjl	103-160	View model · PDB
Predicted = Low	DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:106:155_5z2t_D_1	5z2t	106-155	View model · PDB
Predicted = Low	DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:106:155_6dfy_C_1	6dfy	106-155	View model · PDB
Predicted = Low	DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:17:72_1b72_B_1	1b72	17-72	View model · PDB
Predicted = Low	DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:17:73_5hod_A_1	5hod	17-73	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPF3_DUXB_HUMAN:103:159_3a01_B_1	3a01	103-159	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPF3_DUXB_HUMAN:106:160_3lnq_A_1	3lnq	106-160	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_5z6z_A_1	5z6z	17-155	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_5zfw_A_1	5zfw	17-155	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_5zfy_A_1	5zfy	17-155	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_5zfz_A_1	5zfz	17-155	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_6e8c_A_1	6e8c	17-155	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_6u81_A_1	6u81	17-155	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_6u82_A_1	6u82	17-155	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:72_5zjr_B_1	5zjr	17-72	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:72_5zjt_B_1	5zjt	17-72	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:73_5hod_A_1	5hod	17-73	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
1	6dfy	17:160	106,107	155,155	P:C,D · DNA:E,F	52.0% / 78.0%	92,94	View · PDB DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:106:155_6dfy_C_1
2	5z2t	17:160	106,106	155,155	P:C,D · DNA:E,F	52.0% / 78.0%	94,92	View · PDB DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:106:155_5z2t_D_1
3	1fjl	17:160	103,103	160,155	P:A,B · DNA:D,E	44.8% / 72.4%	89,92	View · PDB DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:103:160_1fjl_A_1
4	3a01	17:160	92,103	164,159	P:A,B · DNA:C,D	43.9% / 66.7%	93,100	View · PDB DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:103:159_3a01_B_1
1	6u82	17:160	17	155	P:A · DNA:B	39.6% / 62.6%	96	View · PDB TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_6u82_A_1
2	6u81	17:160	17	155	P:A · DNA:B,C	39.6% / 62.6%	96	View · PDB TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_6u81_A_1
3	5zfz	17:160	17	155	P:A · DNA:D,E	38.8% / 61.2%	96	View · PDB TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_5zfz_A_1
4	5zfw	17:160	17	155	P:A · DNA:D,E	38.8% / 61.2%	96	View · PDB TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_5zfw_A_1
5	5z6z	17:160	17	155	P:A · DNA:D,E	38.8% / 61.2%	96	View · PDB TFS_sp_A0A1W2PPF3_DUXB_HUMAN:17:155_5z6z_A_1
5	1b72	17:160	19,17	72,72	P:A,B · DNA:D,E	33.9% / 59.3%	79,76	View · PDB DIMER_sp_A0A1W2PPF3_DUXB_HUMAN:17:72_1b72_B_1

Full sequence / unlocalized models18 models

Source	Model	Template	Residues modeled	Actions
Predicted = Low	a0a1w2ppf3.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3_dimer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3_dimer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3_dimer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3_dimer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3_dimer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3_dimer.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3_monomer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3_monomer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3_monomer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3_monomer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3_monomer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppf3_monomer.af3.5	-	Full sequence / not localized	View model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
17-72	PF00046	Homeodomain	overlaps 17-164
103-155	PF00046	Homeodomain	overlaps 17-164