Transcription factor

A0A1W2PPK0 - CPHXL2

Cytoplasmic polyadenylated homeobox-like protein 2

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 400 aa

16 Generated PWM 35 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)0

No generated PWM in this category.

ModCRE16

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:23:79_1fjl_A_1	ModCRE	Homology model	TTGATGCCATCAG	Region 23-79 · 1 3D model		Open · Scan
DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:28:79_1hdd_D_1	ModCRE	Homology model	CCCCGATCATTGGCCAA	Region 28-79 · 1 3D model		Open · Scan
DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:28:79_2hos_A_1	ModCRE	Homology model	CCCCGATTATTGGCGAA	Region 28-79 · 1 3D model		Open · Scan
DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:28:79_2hot_A_1	ModCRE	Homology model	CCCCGTTAATGGCCCAA	Region 28-79 · 1 3D model		Open · Scan
DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:28:79_3hdd_A_1	ModCRE	Homology model	CCCCGGTAATTGGCCAA	Region 28-79 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:23:85_6e8c_A_1	ModCRE	Homology model	AATAATTAAGATTTAAA	Region 23-85 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:26:79_1fjl_B_1	ModCRE	Homology model	GGGGGCCCATCAA	Region 26-79 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:28:79_1du0_B_1	ModCRE	Homology model	GAGAACTTATTGGGGAA	Region 28-79 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:28:79_2hdd_B_1	ModCRE	Homology model	TTTGCGGGGAA	Region 28-79 · 1 3D model		Open · Scan
TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:30:78_2r5z_B_1	ModCRE	Homology model	CCCCGTGATGCCCCCCA	Region 30-78 · 1 3D model		Open · Scan
a0a1w2ppk0.af3.0	ModCRE	AlphaFold3 model	CCCCTGATGACGTCGTTT	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2ppk0.af3.1	ModCRE	AlphaFold3 model	CCCCTTATGAGCCCGTT	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2ppk0.af3.2	ModCRE	AlphaFold3 model	CCCCTTATGACCCCGTT	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2ppk0.af3.3	ModCRE	AlphaFold3 model	CCCCTGATGACGTCGATT	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2ppk0.af3.4	ModCRE	AlphaFold3 model	CCCCTGATGACGTCGTTT	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2ppk0.af3.5	ModCRE	AlphaFold3 model	CCCCTGATGACGCCGTT	AlphaFold3 model · ModCRE PWM		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 400 aa

13-86

Region 13-86 10 PWM

Residues

74 aa

Domains

PF00046 · Homeodomain

3D models

17 active PDBs · 10 summary rows

Templates

1DU0, 1FJL, 1HDD, 1PUF, 2HDD, 2HOS, 2HOT, 2LKX, ...

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

35 active PDB models 10 summary rows

Region 13-8617 models · 10 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:22:78_1puf_B_1	1puf	22-78	View model · PDB
Predicted = Low	DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:23:79_1fjl_A_1	1fjl	23-79	View model · PDB
Predicted = Low	DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:26:78_3a01_B_1	3a01	26-78	View model · PDB
Predicted = Low	DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:28:79_1hdd_D_1	1hdd	28-79	View model · PDB
Predicted = Low	DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:28:79_2hos_A_1	2hos	28-79	View model · PDB
Predicted = Low	DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:28:79_2hot_A_1	2hot	28-79	View model · PDB
Predicted = Low	DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:28:79_3hdd_A_1	3hdd	28-79	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:23:79_1fjl_A_1	1fjl	23-79	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:23:85_6e8c_A_1	6e8c	23-85	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:26:78_2lkx_A_1	2lkx	26-78	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:26:78_3a01_B_1	3a01	26-78	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:26:78_3cmy_A_1	3cmy	26-78	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:26:79_1fjl_B_1	1fjl	26-79	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:26:83_3lnq_A_1	3lnq	26-83	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:28:79_1du0_B_1	1du0	28-79	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:28:79_2hdd_B_1	2hdd	28-79	View model · PDB
Predicted = Low	TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:30:78_2r5z_B_1	2r5z	30-78	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
1	1fjl	21:85	23,26	79,79	P:A,B · DNA:D,E	40.4% / 52.6%	87,94	View · PDB DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:23:79_1fjl_A_1
1	1fjl	21:85	23,26	79,79	P:A,B · DNA:D,E	40.4% / 52.6%	87,94	View · PDB TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:23:79_1fjl_A_1
2	3a01	21:85	13,26	78,78	P:A,B · DNA:C,D	39.6% / 54.7%	83,92	View · PDB DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:26:78_3a01_B_1
2	3a01	21:85	13,26	78,78	P:A,B · DNA:C,D	39.6% / 54.7%	83,92	View · PDB TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:26:78_3a01_B_1
3	3hdd	21:85	28,28	79,79	P:A,B · DNA:C,D	38.5% / 50.0%	94,92	View · PDB DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:28:79_3hdd_A_1
4	1hdd	21:85	28,28	79,79	P:C,D · DNA:A,B	38.5% / 50.0%	91,91	View · PDB DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:28:79_1hdd_D_1
3	3lnq	21:85	26	83	P:A · DNA:B,C	37.9% / 53.4%	100	View · PDB TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:26:83_3lnq_A_1
5	3cmy	21:85	26	78	P:A · DNA:B,C	37.7% / 50.9%	88	View · PDB TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:26:78_3cmy_A_1
4	2lkx	21:85	26	78	P:A · DNA:B,C	35.8% / 56.6%	77	View · PDB TFS_sp_A0A1W2PPK0_CPHL2_HUMAN:26:78_2lkx_A_1
5	1puf	21:85	26,22	86,78	P:A,B · DNA:D,E	33.3% / 52.6%	79,78	View · PDB DIMER_sp_A0A1W2PPK0_CPHL2_HUMAN:22:78_1puf_B_1

Full sequence / unlocalized models18 models

Source	Model	Template	Residues modeled	Actions
Predicted = Low	a0a1w2ppk0.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0_dimer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0_dimer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0_dimer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0_dimer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0_dimer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0_dimer.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0_monomer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0_monomer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0_monomer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0_monomer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0_monomer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2ppk0_monomer.af3.5	-	Full sequence / not localized	View model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
26-78	PF00046	Homeodomain	overlaps 13-86