Transcription factor

A0A1W2PQ54 - ZNF577

Zinc finger protein 577

Homo sapiens (Human) · Unreviewed (UniProtKB/TrEMBL) · 480 aa

93 Generated PWM 24 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)81

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
M00944_2.00	NN 70-40%	CisBP	TCGCTATAA	67.0% identity		Open · Scan
M00943_2.00	NN 70-40%	CisBP	CCCGCTGC	64.7% identity		Open · Scan
M00950_2.00	NN 70-40%	CisBP	GCAGCCCA	63.5% identity		Open · Scan
M00953_2.00	NN 70-40%	CisBP	ATCTATAT	63.5% identity		Open · Scan
M00959_2.00	NN 70-40%	CisBP	GCCCTCCC	63.5% identity		Open · Scan
M04653_2.00	NN 70-40%	CisBP	GGTACGGTTGTCCATGTTGCAA	62.9% identity		Open · Scan
M00939_2.00	NN 70-40%	CisBP	CCACCTCA	61.3% identity		Open · Scan
M04650_2.00	NN 70-40%	CisBP	GCATAACTGCCCCGCTGCC	59.3% identity		Open · Scan
M00955_2.00	NN 70-40%	CisBP	ACGTCCTCT	59.0% identity		Open · Scan
M00960_2.00	NN 70-40%	CisBP	TGCATCCC	59.0% identity		Open · Scan
M08949_2.00	NN 70-40%	CisBP	TTCTATTTCTTCTTGTGTCA	58.9% identity		Open · Scan
M04387_2.00	NN 70-40%	CisBP	CGTGCTCCCC	58.1% identity		Open · Scan
M00952_2.00	NN 70-40%	CisBP	GGATGCTC	57.9% identity		Open · Scan
M00948_2.00	NN 70-40%	CisBP	GCAGCACC	57.8% identity		Open · Scan
M00958_2.00	NN 70-40%	CisBP	CGGCATCCC	57.8% identity		Open · Scan
M04611_2.00	NN 70-40%	CisBP	CTTTCGGACAC	57.4% identity		Open · Scan
M07581_2.00	NN 70-40%	CisBP	TCCCCTGTGCTTCTCTCCCCT	57.4% identity		Open · Scan
M08375_2.00	NN 70-40%	CisBP	TTCCCCATTGGCTACTGCACCGGTCCT	57.3% identity		Open · Scan
MA1124.1	NN 70-40%	JASPAR	CATTCATTCATTC	57.3% identity		Open · Scan
M04621_2.00	NN 70-40%	CisBP	AGCAATTCCGCTCA	57.1% identity		Open · Scan
M08247_2.00	NN 70-40%	CisBP	AAAAATAACAAACGG	56.9% identity		Open · Scan
M00774_2.00	NN 70-40%	CisBP	TTAGTATACACAAGT	56.7% identity		Open · Scan
M02924_2.00	NN 70-40%	CisBP	AGTGTTAACAGAACACCT	56.6% identity		Open · Scan
M04598_2.00	NN 70-40%	CisBP	CGCTAACTCTCCACA	56.6% identity		Open · Scan
M08335_2.00	NN 70-40%	CisBP	AGTCGTTGTCTG	56.6% identity		Open · Scan
M00945_2.00	NN 70-40%	CisBP	CACCGCAC	56.3% identity		Open · Scan
M08267_2.00	NN 70-40%	CisBP	CAGTTTCATTTTCC	56.3% identity		Open · Scan
M04613_2.00	NN 70-40%	CisBP	CTCATGTGCTAATTACAAA	55.9% identity		Open · Scan
M07678_2.00	NN 70-40%	CisBP	CCCGCCCCCTCCTCCCCCTTCCCACCC	55.9% identity		Open · Scan
M08292_2.00	NN 70-40%	CisBP	TGTATTCCTTGTCATGTGTGG	55.9% identity		Open · Scan
M08901_2.00	NN 70-40%	CisBP	CCAGTTCACACC	55.7% identity		Open · Scan
M00782_2.00	NN 70-40%	CisBP	AGTGTGCGCTA	55.5% identity		Open · Scan
M07762_2.00	NN 70-40%	CisBP	GCCGCGCACAGGCTTCTAGCC	55.3% identity		Open · Scan
M08325_2.00	NN 70-40%	CisBP	TTTTTTTTT	55.3% identity		Open · Scan
M07610_2.00	NN 70-40%	CisBP	CCTTCTTCCTCCCCCCTGCCCACC	54.9% identity		Open · Scan
M08334_2.00	NN 70-40%	CisBP	TTTGTTTTTTTCTGATTGCTTTTTACTTAT	54.8% identity		Open · Scan
M08985_2.00	NN 70-40%	CisBP	TGAGGACCTACTGTGTGCC	54.8% identity		Open · Scan
M08254_2.00	NN 70-40%	CisBP	CTGCCCTGGGACTTT	54.4% identity		Open · Scan
M08355_2.00	NN 70-40%	CisBP	GCGAACTCCTATTCATCC	54.4% identity		Open · Scan
M08914_2.00	NN 70-40%	CisBP	ATTTAGTCCATTTACATTTAATGT	54.4% identity		Open · Scan
M07587_2.00	NN 70-40%	CisBP	CCCCCTCCCCAGTCGAGCCCCCGC	53.7% identity		Open · Scan
M08329_2.00	NN 70-40%	CisBP	GCTGCATAGTATTCC	53.7% identity		Open · Scan
M00609_2.00	NN 70-40%	CisBP	GGAAGCCCTA	53.2% identity		Open · Scan
M08255_2.00	NN 70-40%	CisBP	CTCTTCCGGT	53.2% identity		Open · Scan
M07649_2.00	NN 70-40%	CisBP	CCCCCCCCCCCCTCAGGAATGCC	53.1% identity		Open · Scan
M01474_2.00	NN 70-40%	CisBP	CGCCGATCAC	53.0% identity		Open · Scan
M08395_2.00	NN 70-40%	CisBP	GCTGCCTACTCTTCC	53.0% identity		Open · Scan
M04465_2.00	NN 70-40%	CisBP	GTGATTCTTATCTTATCCTT	52.8% identity		Open · Scan
M07777_2.00	NN 70-40%	CisBP	GCCAATTTCCGTGGTGTAAAT	52.5% identity		Open · Scan
MA1656.1	NN 70-40%	JASPAR	CCAAGCCCAACCAG	52.5% identity		Open · Scan
M07579_2.00	NN 70-40%	CisBP	CATCTCCAGGA	52.4% identity		Open · Scan
M08234_2.00	NN 70-40%	CisBP	GTCAACTTGACTGGGCCA	52.4% identity		Open · Scan
M08314_2.00	NN 70-40%	CisBP	ATTCATCAAGGTCCTCAACAATGG	52.4% identity		Open · Scan
M08371_2.00	NN 70-40%	CisBP	CCAGACTTGTCCTCT	52.4% identity		Open · Scan
M07693_2.00	NN 70-40%	CisBP	CTCCTGTGTGTGCCTTGGCTG	52.3% identity		Open · Scan
M07601_2.00	NN 70-40%	CisBP	CAGATGCCGGCACCATGCTTC	52.1% identity		Open · Scan
M07638_2.00	NN 70-40%	CisBP	TGCAGCTCCCTGCCC	52.1% identity		Open · Scan
M04590_2.00	NN 70-40%	CisBP	TGCGCTAACCATTGC	52.0% identity		Open · Scan
M07657_2.00	NN 70-40%	CisBP	CCCCTGCATGTCCCCATTTTT	52.0% identity		Open · Scan
M07660_2.00	NN 70-40%	CisBP	CCGCGCCTACCTGAGGGCGCGGGCCTGGGG	52.0% identity		Open · Scan
M07701_2.00	NN 70-40%	CisBP	CCTGGGCTAGGCCCTGGC	51.8% identity		Open · Scan
M08392_2.00	NN 70-40%	CisBP	CTTCACCTGCTGAGG	51.6% identity		Open · Scan
M08252_2.00	NN 70-40%	CisBP	CCGGCTCCAGCACCC	51.4% identity		Open · Scan
M01439_2.00	NN 70-40%	CisBP	TTACGCCACA	51.0% identity		Open · Scan
M07723_2.00	NN 70-40%	CisBP	CCGCTGCTCCCTGCT	51.0% identity		Open · Scan
M08386_2.00	NN 70-40%	CisBP	GCCTTAAAAGCTCAGCAC	51.0% identity		Open · Scan
M07588_2.00	NN 70-40%	CisBP	TCCTTCCCTCTTTCC	50.9% identity		Open · Scan
M07731_2.00	NN 70-40%	CisBP	TTTCCCAGCAGCAACAGCACCGCCCCCCCC	50.6% identity		Open · Scan
M07605_2.00	NN 70-40%	CisBP	TATTTTTTTTTATTTTTTTTTTTTTTTTTT	50.5% identity		Open · Scan
M08357_2.00	NN 70-40%	CisBP	GAGCCTGCTACTGAGCCTGGG	50.4% identity		Open · Scan
M02896_2.00	NN 70-40%	CisBP	TGCTTTCTAGGAATTCA	50.3% identity		Open · Scan
MA0731.1	NN 70-40%	JASPAR	TGCTTTCTAGGAATTCA	50.3% identity		Open · Scan
M07706_2.00	NN 70-40%	CisBP	GTCTTTGAGAGGGCCCAGATGTTGGACTTA	50.1% identity		Open · Scan
M00142_2.00	NN 70-40%	CisBP	GTGCTCCT	50.0% identity		Open · Scan
M01440_2.00	NN 70-40%	CisBP	TACGCCAC	50.0% identity		Open · Scan
M03671_2.00	NN 70-40%	CisBP	ATTACCATACAAGTGCAC	50.0% identity		Open · Scan
M05844_2.00	NN 70-40%	CisBP	TCACCTGT	50.0% identity		Open · Scan
M08908_2.00	NN 70-40%	CisBP	GCTGCTGCTTCTGCTG	50.0% identity		Open · Scan
MA0103.1	NN 70-40%	JASPAR	CACCTG	50.0% identity		Open · Scan
MA0103.2	NN 70-40%	JASPAR	CCTCACCTG	50.0% identity		Open · Scan
MA0740.1	NN 70-40%	JASPAR	GGCCACGCCCCCTT	50.0% identity		Open · Scan

ModCRE12

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
DIMER_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:212:261_1llm_D_1	ModCRE	Homology model	ACCCGCGCGGGG	Region 212-261 · 1 3D model		Open · Scan
TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:131:379_5v3j_E_1	ModCRE	Homology model	CCTCCCCTGTGGCCCCCCCCCCC	Region 131-379 · 1 3D model		Open · Scan
TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:131:379_5v3m_C_1	ModCRE	Homology model	CCGCCCGCGCCCCCCCCCCCCCGC	Region 131-379 · 1 3D model		Open · Scan
TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:131:379_5wjq_D_1	ModCRE	Homology model	GCGCCGGGCCCCCCCGGGCCCCCCCAA	Region 131-379 · 1 3D model		Open · Scan
TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:195:348_2i13_A_1	ModCRE	Homology model	AGGCCGAAGGAGGCCGCGATT	Region 195-348 · 1 3D model		Open · Scan
TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:267:376_5ei9_E_1	ModCRE	Homology model	GCCCCCCACCGCCCCCC	Region 267-376 · 1 3D model		Open · Scan
a0a1w2pq54.af3.0	ModCRE	AlphaFold3 model	GCCCGGCCCCCCGGCCGGCCCCCACCGC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2pq54.af3.1	ModCRE	AlphaFold3 model	GTCCCCAGCGCCGCTCCTAACGCCGCTCC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2pq54.af3.2	ModCRE	AlphaFold3 model	GGAGCGGAGGCAGGCTCGGCGCTAGGCC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2pq54.af3.3	ModCRE	AlphaFold3 model	GCCCGGCCCCCCGGCCGGCCCCCACCGC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2pq54.af3.4	ModCRE	AlphaFold3 model	GGCCCCAACGCCCCTTCTAACCCCGCTGC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1w2pq54.af3.5	ModCRE	AlphaFold3 model	GGAGCGGGAGTAGACTAGGAGCTGGGCCC	AlphaFold3 model · ModCRE PWM		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 480 aa

131-379

Region 131-379 6 PWM

Residues

249 aa

Domains

PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type

3D models

6 active PDBs · 6 summary rows

Templates

1LLM, 2I13, 5EI9, 5V3J, 5V3M, 5WJQ

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

24 active PDB models 6 summary rows

Region 131-3796 models · 6 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:212:261_1llm_D_1	1llm	212-261	View model · PDB
Predicted = Low	TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:131:379_5v3j_E_1	5v3j	131-379	View model · PDB
Predicted = Low	TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:131:379_5v3m_C_1	5v3m	131-379	View model · PDB
Predicted = Low	TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:131:379_5wjq_D_1	5wjq	131-379	View model · PDB
Predicted = Low	TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:195:348_2i13_A_1	2i13	195-348	View model · PDB
Predicted = Low	TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:267:376_5ei9_E_1	5ei9	267-376	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
5	5ei9	131:379	267	376	P:E · DNA:A,B	60.9% / 74.5%	99	View · PDB TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:267:376_5ei9_E_1
4	2i13	131:379	195	348	P:A · DNA:C,D	60.4% / 73.4%	100	View · PDB TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:195:348_2i13_A_1
1	5v3m	131:379	131	379	P:C · DNA:A,B	49.4% / 62.7%	89	View · PDB TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:131:379_5v3m_C_1
2	5v3j	131:379	131	379	P:E · DNA:A,B	49.4% / 62.7%	89	View · PDB TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:131:379_5v3j_E_1
1	1llm	131:379	212,212	261,261	P:C,D · DNA:A,B	48.0% / 60.0%	57,58	View · PDB DIMER_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:212:261_1llm_D_1
3	5wjq	131:379	131	379	P:D · DNA:A,B	47.4% / 63.5%	88	View · PDB TFS_tr_A0A1W2PQ54_A0A1W2PQ54_HUMAN:131:379_5wjq_D_1

Full sequence / unlocalized models18 models

Source	Model	Template	Residues modeled	Actions
Predicted = Low	a0a1w2pq54.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54_dimer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54_dimer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54_dimer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54_dimer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54_dimer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54_dimer.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54_monomer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54_monomer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54_monomer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54_monomer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54_monomer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1w2pq54_monomer.af3.5	-	Full sequence / not localized	View model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
22-63	PF01352	KRAB box	No overlap with loaded model regions
158-179	PF00096	Zinc finger, C2H2 type	overlaps 131-379
188-208	PF00096	Zinc finger, C2H2 type	overlaps 131-379
214-236	PF00096	Zinc finger, C2H2 type	overlaps 131-379
242-264	PF00096	Zinc finger, C2H2 type	overlaps 131-379
272-292	PF00096	Zinc finger, C2H2 type	overlaps 131-379
298-320	PF00096	Zinc finger, C2H2 type	overlaps 131-379
326-348	PF00096	Zinc finger, C2H2 type	overlaps 131-379
354-376	PF00096	Zinc finger, C2H2 type	overlaps 131-379