Transcription factor

A0A1X7SC99 - ZEB2

Zinc finger E-box binding homeobox 2

Homo sapiens (Human) · Unreviewed (UniProtKB/TrEMBL) · 612 aa

32 Generated PWM 16 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)17

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
M04463_2.00	NN 70-40%	CisBP	CACCACGCCCA	61.5% identity		Open · Scan
MA0039.1	NN 70-40%	JASPAR	TAAAGGAAGG	61.5% identity		Open · Scan
MA0039.3	NN 70-40%	JASPAR	CCACACCCTGC	61.5% identity		Open · Scan
MA1515.1	NN 70-40%	JASPAR	CACCACGCCCA	61.5% identity		Open · Scan
M07842_2.00	NN 70-40%	CisBP	CTCACCTG	60.6% identity		Open · Scan
M04611_2.00	NN 70-40%	CisBP	CTTTCGGACAC	57.5% identity		Open · Scan
M04651_2.00	NN 70-40%	CisBP	TTCACTATTATAGTGAA	57.5% identity		Open · Scan
M06179_2.00	NN 70-40%	CisBP	TAAGCCTATAGA	56.8% identity		Open · Scan
M00019_2.00	NN 70-40%	CisBP	ACCCCTAATT	54.0% identity		Open · Scan
M00142_2.00	NN 70-40%	CisBP	GTGCTCCT	53.6% identity		Open · Scan
M04465_2.00	NN 70-40%	CisBP	GTGATTCTTATCTTATCCTT	53.3% identity		Open · Scan
MA0103.1	NN 70-40%	JASPAR	CACCTG	50.3% identity		Open · Scan
MA0103.2	NN 70-40%	JASPAR	CCTCACCTG	50.1% identity		Open · Scan
M01468_2.00	NN 70-40%	CisBP	TTACCCCTGA	50.0% identity		Open · Scan
M01531_2.00	NN 70-40%	CisBP	CCCCCCCTAAAT	50.0% identity		Open · Scan
M07625_2.00	NN 70-40%	CisBP	TCTCTCTCTCTCTCTCTCTCTCTCTCTCTC	50.0% identity		Open · Scan
M08295_2.00	NN 70-40%	CisBP	CTGCTGGAATCTCCA	50.0% identity		Open · Scan

ModCRE15

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
DIMER_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:344:374_3coq_B_1	ModCRE	Homology model	AATAACTGTTAA	Region 344-374 · 1 3D model		Open · Scan
TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:264_5k5l_F_1	ModCRE	Homology model	GTAACACACCCGTA	Region 213-264 · 1 3D model		Open · Scan
TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_5kkq_A_1	ModCRE	Homology model	TTCCACCAACTAGCCGG	Region 213-332 · 1 3D model		Open · Scan
TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_5t00_A_1	ModCRE	Homology model	TCTCCACGCGCTGCCGG	Region 213-332 · 1 3D model		Open · Scan
TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_5t0u_A_1	ModCRE	Homology model	TTCCCCTAGCGCTGCGCGATCC	Region 213-332 · 1 3D model		Open · Scan
TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_5yef_A_1	ModCRE	Homology model	ACAAACCGGGGGCCCGGGAAAAT	Region 213-332 · 1 3D model		Open · Scan
TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_8sss_A_1	ModCRE	Homology model	TTTCGCAGGGCGCGCCAGGTTC	Region 213-332 · 1 3D model		Open · Scan
TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:280:329_4gzn_C_1	ModCRE	Homology model	GGCCCCCCCC	Region 280-329 · 1 3D model		Open · Scan
TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:280:329_4m9v_C_1	ModCRE	Homology model	GACCCCCCCC	Region 280-329 · 1 3D model		Open · Scan
a0a1x7sc99.af3.0	ModCRE	AlphaFold3 model	TAAACGTCGGCGCGCGCGCGCGGCACCTTG	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1x7sc99.af3.1	ModCRE	AlphaFold3 model	CTCTCAACGCCGCGCGCGCGCGCGCGCCGC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1x7sc99.af3.2	ModCRE	AlphaFold3 model	GGGAACCGGCGCGTGCGCGAGCGGAGTGAC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1x7sc99.af3.3	ModCRE	AlphaFold3 model	TAAACGTCGGCGCGCGCGCGCGGCACCTTG	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1x7sc99.af3.4	ModCRE	AlphaFold3 model	CCCGCCCGGGACCGTGGTGGTCCCACGGAT	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a1x7sc99.af3.5	ModCRE	AlphaFold3 model	GGGGTACCGGGATAGTTATATAAGAGAACT	AlphaFold3 model · ModCRE PWM		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 612 aa

213-332

344-374

Region 213-332 8 PWM

Residues

120 aa

Domains

PF05605 · Drought induced 19 protein (Di19), zinc-binding PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type

3D models

9 active PDBs · 6 summary rows

Templates

1LLM, 4GZN, 4M9V, 5K5L, 5KKQ, 5T00, 5T0U, 5YEF, ...

Sources

Predicted = Low

Scan this region Show models

Region 344-374 1 PWM

Residues

31 aa

Domains

No overlapping PFAM annotation recorded

3D models

1 active PDB

Templates

3COQ

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

16 active PDB models 6 summary rows

Region 213-3329 models · 6 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:280:328_1llm_D_1	1llm	280-328	View model · PDB
Predicted = Low	TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:264_5k5l_F_1	5k5l	213-264	View model · PDB
Predicted = Low	TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_5kkq_A_1	5kkq	213-332	View model · PDB
Predicted = Low	TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_5t00_A_1	5t00	213-332	View model · PDB
Predicted = Low	TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_5t0u_A_1	5t0u	213-332	View model · PDB
Predicted = Low	TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_5yef_A_1	5yef	213-332	View model · PDB
Predicted = Low	TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_8sss_A_1	8sss	213-332	View model · PDB
Predicted = Low	TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:280:329_4gzn_C_1	4gzn	280-329	View model · PDB
Predicted = Low	TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:280:329_4m9v_C_1	4m9v	280-329	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
1	1llm	213:336	280,280	328,328	P:C,D · DNA:A,B	36.7% / 55.1%	56,57	View · PDB DIMER_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:280:328_1llm_D_1
1	5kkq	213:336	213	332	P:A · DNA:B,C	36.7% / 51.7%	72	View · PDB TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_5kkq_A_1
2	5t00	213:336	213	332	P:A · DNA:B,C	36.7% / 51.7%	74	View · PDB TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_5t00_A_1
3	5t0u	213:336	213	332	P:A · DNA:B,C	36.7% / 51.7%	62	View · PDB TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_5t0u_A_1
4	5yef	213:336	213	332	P:A · DNA:C,D	36.7% / 51.7%	62	View · PDB TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_5yef_A_1
5	8sss	213:336	213	332	P:A · DNA:B,C	36.7% / 51.7%	53	View · PDB TFS_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:213:332_8sss_A_1

Region 344-3741 model

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_tr_A0A1X7SC99_A0A1X7SC99_HUMAN:344:374_3coq_B_1	3coq	344-374	View model · PDB

Full sequence / unlocalized models6 models

Source	Model	Template	Residues modeled	Actions
Predicted = Low	a0a1x7sc99.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1x7sc99.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1x7sc99.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1x7sc99.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1x7sc99.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a1x7sc99.af3.5	-	Full sequence / not localized	View model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
211-262	PF05605	Drought induced 19 protein (Di19), zinc-binding	overlaps 213-332
282-304	PF00096	Zinc finger, C2H2 type	overlaps 213-332
310-330	PF00096	Zinc finger, C2H2 type	overlaps 213-332