Transcription factor

A0A2R8Y6X0 - ADNP

Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein)

Homo sapiens (Human) · Unreviewed (UniProtKB/TrEMBL) · 874 aa

11 Generated PWM 28 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)0

No generated PWM in this category.

ModCRE11

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:211:245_4f6n_A_1	ModCRE	Homology model	CTAGTCGAGG	Region 211-245 · 1 3D model		Open · Scan
TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:211:245_6df9_A_1	ModCRE	Homology model	CACGCCGAGGCG	Region 211-245 · 1 3D model		Open · Scan
TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:211:245_6dfa_A_1	ModCRE	Homology model	AGTGCCGAGGCA	Region 211-245 · 1 3D model		Open · Scan
TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:211:245_6v8u_A_1	ModCRE	Homology model	TGAGTCGAGCAG	Region 211-245 · 1 3D model		Open · Scan
TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:286:307_2drp_A_1	ModCRE	Homology model	AAGGATCTTCCA	Region 286-307 · 1 3D model		Open · Scan
a0a2r8y6x0.af3.0	ModCRE	AlphaFold3 model	AATGGAAAATTTTTTAAATTTGCCCCGTG	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a2r8y6x0.af3.1	ModCRE	AlphaFold3 model	AACTTATTAGCTCTGTTTCTTGTAGGAA	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a2r8y6x0.af3.2	ModCRE	AlphaFold3 model	AATGGAAAATTTTTTAAATTTGCCCCGTG	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a2r8y6x0.af3.3	ModCRE	AlphaFold3 model	TTTGGCAAACATTTTAAAATTTTGAAA	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a2r8y6x0.af3.4	ModCRE	AlphaFold3 model	CCCAGTGAATTTTAAAACAAAAAGTTC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a2r8y6x0.af3.5	ModCRE	AlphaFold3 model	CCCTTTTAACAATAATTTTTAT	AlphaFold3 model · ModCRE PWM		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 874 aa

211-245

286-307

543-582

Region 211-245 4 PWM

Residues

35 aa

Domains

PF26748 · Adnp2-like, C2H2-type zinc finger

3D models

4 active PDBs · 4 summary rows

Templates

4F6N, 6DF9, 6DFA, 6V8U

Sources

Predicted = Low

Scan this region Show models

Region 286-307 1 PWM

Residues

22 aa

Domains

No overlapping PFAM annotation recorded

3D models

1 active PDB · 1 summary row

Templates

2DRP

Sources

Predicted = Low

Scan this region Show models

Region 543-582 0 PWM

Residues

40 aa

Domains

PF00046 · Homeodomain

3D models

5 active PDBs · 5 summary rows

Templates

1DU0, 1HDD, 2HDD, 3D1N, 3HDD

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

28 active PDB models 10 summary rows

Region 211-2454 models · 4 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:211:245_4f6n_A_1	4f6n	211-245	View model · PDB
Predicted = Low	TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:211:245_6df9_A_1	6df9	211-245	View model · PDB
Predicted = Low	TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:211:245_6dfa_A_1	6dfa	211-245	View model · PDB
Predicted = Low	TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:211:245_6v8u_A_1	6v8u	211-245	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
1	6dfa	211:245	211	245	P:A · DNA:D,E	31.4% / 42.9%	29	View · PDB TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:211:245_6dfa_A_1
3	6v8u	211:245	211	245	P:A · DNA:D,E	31.4% / 42.9%	29	View · PDB TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:211:245_6v8u_A_1
4	4f6n	211:245	211	245	P:A · DNA:D,E	31.4% / 42.9%	29	View · PDB TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:211:245_4f6n_A_1
5	6df9	211:245	211	245	P:A · DNA:D,E	31.4% / 42.9%	30	View · PDB TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:211:245_6df9_A_1

Region 286-3071 model · 1 summary row

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:286:307_2drp_A_1	2drp	286-307	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
2	2drp	211:245	286	307	P:A · DNA:B,C	36.4% / 63.6%	34	View · PDB TFS_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:286:307_2drp_A_1

Region 543-5825 models · 5 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:543:581_3d1n_L_1	3d1n	543-581	View model · PDB
Predicted = Low	DIMER_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:543:582_1du0_B_1	1du0	543-582	View model · PDB
Predicted = Low	DIMER_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:543:582_1hdd_D_1	1hdd	543-582	View model · PDB
Predicted = Low	DIMER_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:543:582_2hdd_A_1	2hdd	543-582	View model · PDB
Predicted = Low	DIMER_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:543:582_3hdd_A_1	3hdd	543-582	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
2	3d1n	211:245	543,543	581,581	P:K,L · DNA:C,D	38.5% / 56.4%	26,26	View · PDB DIMER_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:543:581_3d1n_L_1
1	1du0	211:245	543,543	582,582	P:A,B · DNA:C,D	37.5% / 60.0%	75,71	View · PDB DIMER_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:543:582_1du0_B_1
3	3hdd	211:245	543,543	582,582	P:A,B · DNA:C,D	37.5% / 57.5%	72,71	View · PDB DIMER_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:543:582_3hdd_A_1
4	2hdd	211:245	543,543	582,582	P:A,B · DNA:C,D	37.5% / 57.5%	72,71	View · PDB DIMER_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:543:582_2hdd_A_1
5	1hdd	211:245	543,543	582,582	P:C,D · DNA:A,B	37.5% / 57.5%	70,70	View · PDB DIMER_tr_A0A2R8Y6X0_A0A2R8Y6X0_HUMAN:543:582_1hdd_D_1

Full sequence / unlocalized models18 models

Source	Model	Template	Residues modeled	Actions
Predicted = Low	a0a2r8y6x0.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0_dimer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0_dimer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0_dimer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0_dimer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0_dimer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0_dimer.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0_monomer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0_monomer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0_monomer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0_monomer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0_monomer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a2r8y6x0_monomer.af3.5	-	Full sequence / not localized	View model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
218-242	PF26748	Adnp2-like, C2H2-type zinc finger	overlaps 211-245
541-582	PF00046	Homeodomain	overlaps 543-582