Transcription factor

A0A669KB72 - HOMEZ

Homeobox and leucine zipper protein Homez (Homeodomain leucine zipper-containing factor)

Homo sapiens (Human) · Unreviewed (UniProtKB/TrEMBL) · 439 aa

17 Generated PWM 28 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)1

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
M00518_2.00	NN 70-40%	CisBP	AAATCGATTT	64.8% identity		Open · Scan

ModCRE16

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_1du0_A_1	ModCRE	Homology model	GTGCCCCGTTTTTTTT	Region 253-301 · 1 3D model		Open · Scan
DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_2hdd_A_1	ModCRE	Homology model	TACTCCAAGTGGTTTT	Region 253-301 · 1 3D model		Open · Scan
DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_2hos_A_1	ModCRE	Homology model	TGCCCCCGGTGGTTTT	Region 253-301 · 1 3D model		Open · Scan
DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_2hot_A_1	ModCRE	Homology model	TCCCCCAAGTGGTTTT	Region 253-301 · 1 3D model		Open · Scan
DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_3hdd_A_1	ModCRE	Homology model	GTGCCCCACTGTTTT	Region 253-301 · 1 3D model		Open · Scan
TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_5ef6_A_1	ModCRE	Homology model	GCCCATTTTTTTAAAAAA	Region 345-399 · 1 3D model		Open · Scan
TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_5eg0_B_1	ModCRE	Homology model	CCCATGTTTATGAA	Region 345-399 · 1 3D model		Open · Scan
TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_5ego_B_1	ModCRE	Homology model	GCTCAGTTTTAAAAA	Region 345-399 · 1 3D model		Open · Scan
TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_5no6_A_1	ModCRE	Homology model	ATTTTATACAAAAAACCC	Region 345-399 · 1 3D model		Open · Scan
TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_7psx_A_1	ModCRE	Homology model	CCAATTTTTATTAAAAAA	Region 345-399 · 1 3D model		Open · Scan
a0a669kb72.af3.0	ModCRE	AlphaFold3 model	ACCCTCTAAATTGGCACATC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a669kb72.af3.1	ModCRE	AlphaFold3 model	GGCGTGCCAAATTTTAAATAACG	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a669kb72.af3.2	ModCRE	AlphaFold3 model	GGCGTGCAAACTCATTGCGTC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a669kb72.af3.3	ModCRE	AlphaFold3 model	TGGGGGCTCACTTATTGCCGC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a669kb72.af3.4	ModCRE	AlphaFold3 model	CCCTTTTGAAGGTAGCCCGTC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a669kb72.af3.5	ModCRE	AlphaFold3 model	ACCCTCTAAATTGGCACATC	AlphaFold3 model · ModCRE PWM		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 439 aa

253-301

345-399

Region 253-301 5 PWM

Residues

49 aa

Domains

No overlapping PFAM annotation recorded

3D models

5 active PDBs · 5 summary rows

Templates

1DU0, 2HDD, 2HOS, 2HOT, 3HDD

Sources

Predicted = Low

Scan this region Show models

Region 345-399 5 PWM

Residues

55 aa

Domains

PF11569 · Homeodomain leucine-zipper encoding, Homez

3D models

5 active PDBs · 5 summary rows

Templates

5EF6, 5EG0, 5EGO, 5NO6, 7PSX

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

28 active PDB models 10 summary rows

Region 253-3015 models · 5 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_1du0_A_1	1du0	253-301	View model · PDB
Predicted = Low	DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_2hdd_A_1	2hdd	253-301	View model · PDB
Predicted = Low	DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_2hos_A_1	2hos	253-301	View model · PDB
Predicted = Low	DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_2hot_A_1	2hot	253-301	View model · PDB
Predicted = Low	DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_3hdd_A_1	3hdd	253-301	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
1	1du0	345:399	253,253	301,301	P:A,B · DNA:C,D	32.7% / 49.0%	92,87	View · PDB DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_1du0_A_1
2	2hdd	345:399	253,253	301,301	P:A,B · DNA:C,D	32.7% / 49.0%	89,87	View · PDB DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_2hdd_A_1
5	3hdd	345:399	253,253	301,301	P:A,B · DNA:C,D	32.7% / 49.0%	89,87	View · PDB DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_3hdd_A_1
3	2hot	345:399	253,253	301,301	P:A,B · DNA:C,D	30.6% / 49.0%	87,84	View · PDB DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_2hot_A_1
4	2hos	345:399	253,253	301,301	P:A,B · DNA:C,D	30.6% / 49.0%	87,84	View · PDB DIMER_tr_A0A669KB72_A0A669KB72_HUMAN:253:301_2hos_A_1

Region 345-3995 models · 5 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_5ef6_A_1	5ef6	345-399	View model · PDB
Predicted = Low	TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_5eg0_B_1	5eg0	345-399	View model · PDB
Predicted = Low	TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_5ego_B_1	5ego	345-399	View model · PDB
Predicted = Low	TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_5no6_A_1	5no6	345-399	View model · PDB
Predicted = Low	TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_7psx_A_1	7psx	345-399	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
1	5no6	345:399	345	399	P:A · DNA:C,F	29.1% / 58.2%	88	View · PDB TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_5no6_A_1
2	5ego	345:399	345	399	P:B · DNA:D,E	29.1% / 58.2%	87	View · PDB TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_5ego_B_1
3	7psx	345:399	345	399	P:A · DNA:C,F	29.1% / 58.2%	90	View · PDB TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_7psx_A_1
4	5eg0	345:399	345	399	P:B · DNA:D,E	29.1% / 58.2%	90	View · PDB TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_5eg0_B_1
5	5ef6	345:399	345	399	P:A · DNA:C,F	29.1% / 58.2%	90	View · PDB TFS_tr_A0A669KB72_A0A669KB72_HUMAN:345:399_5ef6_A_1

Full sequence / unlocalized models18 models

Source	Model	Template	Residues modeled	Actions
Predicted = Low	a0a669kb72.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72_dimer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72_dimer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72_dimer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72_dimer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72_dimer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72_dimer.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72_monomer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72_monomer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72_monomer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72_monomer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72_monomer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a669kb72_monomer.af3.5	-	Full sequence / not localized	View model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
342-398	PF11569	Homeodomain leucine-zipper encoding, Homez	overlaps 345-399