Transcription factor

A0A8V8TM49 - TPRX1

Tetrapeptide repeat homeobox 1

Homo sapiens (Human) · Unreviewed (UniProtKB/TrEMBL) · 350 aa

27 Generated PWM 34 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)8

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
M03250_2.00	NN 70-40%	CisBP	TTAATCCG	53.4% identity		Open · Scan
MA0711.1	NN 70-40%	JASPAR	TTAATCCG	53.4% identity		Open · Scan
M00679_2.00	NN 70-40%	CisBP	TTAATCCC	50.8% identity		Open · Scan
M03076_2.00	NN 70-40%	CisBP	TTAATTAAATTAA	50.8% identity		Open · Scan
MA0874.1	NN 70-40%	JASPAR	GTCCATTAATTAATGGA	50.8% identity		Open · Scan
M09208_2.00	NN 70-40%	CisBP	CCTAATCCTCTTA	50.0% identity		Open · Scan
M09569_2.00	NN 70-40%	CisBP	GTTAATCCCT	50.0% identity		Open · Scan
MA0467.1	NN 70-40%	JASPAR	AAGAGGATTAG	50.0% identity		Open · Scan

ModCRE19

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:19:78_1fjl_A_1	ModCRE	Homology model	TTAATTAAATTAG	Region 19-78 · 1 3D model		Open · Scan
DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:23:80_2r5y_A_1	ModCRE	Homology model	CAAGGTAATAAATTAATCA	Region 23-80 · 1 3D model		Open · Scan
DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:77_4qtr_A_1	ModCRE	Homology model	GCAAATTTATTGC	Region 24-77 · 1 3D model		Open · Scan
DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:78_1b8i_A_1	ModCRE	Homology model	GGTAATTAATCAC	Region 24-78 · 1 3D model		Open · Scan
DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:78_4uus_A_1	ModCRE	Homology model	GGTAATTTATTTG	Region 24-78 · 1 3D model		Open · Scan
TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:20:74_2lkx_A_1	ModCRE	Homology model	GGGGAATAATTGA	Region 20-74 · 1 3D model		Open · Scan
TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:20:75_1fjl_B_1	ModCRE	Homology model	CGGCCCTAATTAA	Region 20-75 · 1 3D model		Open · Scan
TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:20:78_3cmy_A_1	ModCRE	Homology model	TATTTTT	Region 20-78 · 1 3D model		Open · Scan
TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:20:85_1ahd_P_1	ModCRE	Homology model	ATTAAATGGTTTAT	Region 20-85 · 1 3D model		Open · Scan
TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:22:80_2r5z_A_1	ModCRE	Homology model	CCAAAATTAATTAATTA	Region 22-80 · 1 3D model		Open · Scan
TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:77_4qtr_A_1	ModCRE	Homology model	GCAAATTAATTGC	Region 24-77 · 1 3D model		Open · Scan
TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:78_1b8i_A_1	ModCRE	Homology model	GCCAATTTTTTTC	Region 24-78 · 1 3D model		Open · Scan
TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:84_7q4n_K_1	ModCRE	Homology model	ACCGAAAATATTCCTGG	Region 24-84 · 1 3D model		Open · Scan
a0a8v8tm49.af3.0	ModCRE	AlphaFold3 model	GGCATAATTCCCCCCCC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a8v8tm49.af3.1	ModCRE	AlphaFold3 model	GGCTTAATTAGGCCCA	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a8v8tm49.af3.2	ModCRE	AlphaFold3 model	GAAATAATTGCCCCCA	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a8v8tm49.af3.3	ModCRE	AlphaFold3 model	GGCATAATTCCCCCCCC	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a8v8tm49.af3.4	ModCRE	AlphaFold3 model	GGCATAATTGGGCCCAA	AlphaFold3 model · ModCRE PWM		Open · Scan
a0a8v8tm49.af3.5	ModCRE	AlphaFold3 model	CCGGAATAATTTCGCCCC	AlphaFold3 model · ModCRE PWM		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 350 aa

18-85

Region 18-85 13 PWM

Residues

68 aa

Domains

PF00046 · Homeodomain

3D models

16 active PDBs · 10 summary rows

Templates

1AHD, 1B8I, 1FJL, 1PUF, 2LKX, 2R5Y, 2R5Z, 3CMY, ...

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

34 active PDB models 10 summary rows

Region 18-8516 models · 10 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:18:77_1puf_A_1	1puf	18-77	View model · PDB
Predicted = Low	DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:19:78_1fjl_A_1	1fjl	19-78	View model · PDB
Predicted = Low	DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:22:80_2r5z_A_1	2r5z	22-80	View model · PDB
Predicted = Low	DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:23:80_2r5y_A_1	2r5y	23-80	View model · PDB
Predicted = Low	DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:77_4qtr_A_1	4qtr	24-77	View model · PDB
Predicted = Low	DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:78_1b8i_A_1	1b8i	24-78	View model · PDB
Predicted = Low	DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:78_4uus_A_1	4uus	24-78	View model · PDB
Predicted = Low	TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:19:78_1fjl_A_1	1fjl	19-78	View model · PDB
Predicted = Low	TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:20:74_2lkx_A_1	2lkx	20-74	View model · PDB
Predicted = Low	TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:20:75_1fjl_B_1	1fjl	20-75	View model · PDB
Predicted = Low	TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:20:78_3cmy_A_1	3cmy	20-78	View model · PDB
Predicted = Low	TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:20:85_1ahd_P_1	1ahd	20-85	View model · PDB
Predicted = Low	TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:22:80_2r5z_A_1	2r5z	22-80	View model · PDB
Predicted = Low	TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:77_4qtr_A_1	4qtr	24-77	View model · PDB
Predicted = Low	TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:78_1b8i_A_1	1b8i	24-78	View model · PDB
Predicted = Low	TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:84_7q4n_K_1	7q4n	24-84	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
2	2lkx	16:93	20	74	P:A · DNA:B,C	45.5% / 69.1%	80	View · PDB TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:20:74_2lkx_A_1
1	1fjl	16:93	19,20	78,75	P:A,B · DNA:D,E	43.3% / 68.3%	92,98	View · PDB TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:20:75_1fjl_B_1
1	1fjl	16:93	19,20	78,75	P:A,B · DNA:D,E	43.3% / 68.3%	92,98	View · PDB DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:19:78_1fjl_A_1
3	4uus	16:93	24,44	78,74	P:A,B · DNA:C,D	41.8% / 60.0%	82,44	View · PDB DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:78_4uus_A_1
4	1b8i	16:93	24,44	78,74	P:A,B · DNA:C,D	41.8% / 60.0%	88,53	View · PDB DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:78_1b8i_A_1
5	7q4n	16:93	24	84	P:K · DNA:A,D	41.3% / 63.5%	92	View · PDB TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:24:84_7q4n_K_1
3	3cmy	16:93	20	78	P:A · DNA:B,C	40.7% / 61.0%	98	View · PDB TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:20:78_3cmy_A_1
5	2r5z	16:93	22,44	80,74	P:A,B · DNA:C,D	39.0% / 62.7%	78,52	View · PDB DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:22:80_2r5z_A_1
2	1puf	16:93	18,21	77,74	P:A,B · DNA:D,E	38.3% / 63.3%	77,73	View · PDB DIMER_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:18:77_1puf_A_1
4	1ahd	16:93	20	85	P:P · DNA:A,B	34.8% / 60.6%	97	View · PDB TFS_tr_A0A8V8TM49_A0A8V8TM49_HUMAN:20:85_1ahd_P_1

Full sequence / unlocalized models18 models

Source	Model	Template	Residues modeled	Actions
Predicted = Low	a0a8v8tm49.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49_dimer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49_dimer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49_dimer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49_dimer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49_dimer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49_dimer.af3.5	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49_monomer.af3.0	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49_monomer.af3.1	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49_monomer.af3.2	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49_monomer.af3.3	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49_monomer.af3.4	-	Full sequence / not localized	View model · PDB
Predicted = Low	a0a8v8tm49_monomer.af3.5	-	Full sequence / not localized	View model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
21-74	PF00046	Homeodomain	overlaps 18-85