ModCRE DB

Transcription factor

A6NFD8 - HELT

Hairy and enhancer of split-related protein HELT (HES/HEY-like transcription factor)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 242 aa

16 Generated PWM 18 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)5
MotifPredictionSourceDNA bindingSupportLogoActions
MA0616.1 NN 70-40% JASPAR TAACGACACGTGC 56.2% identity Open · Scan
M04192_2.00 NN 70-40% CisBP CGCACGTGCC 55.1% identity Open · Scan
MA0822.1 NN 70-40% JASPAR TGGCACGTGCCA 55.1% identity Open · Scan
M05959_2.00 NN 70-40% CisBP GGCACGTGCCA 52.9% identity Open · Scan
M09656_2.00 NN 70-40% CisBP GGCACGCGCC 52.9% identity Open · Scan
ModCRE11
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_sp_A6NFD8_HELT_HUMAN:15:63_1hlo_A_1 ModCRE Homology model GCCCACGTGGT Region 15-63 · 1 3D model Open · Scan
DIMER_sp_A6NFD8_HELT_HUMAN:4:67_1mdy_A_1 ModCRE Homology model TGCCCAGGGGGGCC Region 4-67 · 1 3D model Open · Scan
DIMER_sp_A6NFD8_HELT_HUMAN:9:68_4h10_A_1 ModCRE Homology model CGGCCACGTGCTTC Region 9-68 · 1 3D model Open · Scan
TFS_sp_A6NFD8_HELT_HUMAN:14:62_8osl_P_1 ModCRE Homology model GGGCGCTGGTGCACGCGG Region 14-62 · 1 3D model Open · Scan
TFS_sp_A6NFD8_HELT_HUMAN:14:65_1a0a_A_1 ModCRE Homology model GCCACGTGGTGAGCACC Region 14-65 · 1 3D model Open · Scan
TFS_sp_A6NFD8_HELT_HUMAN:14:65_4atk_A_1 ModCRE Homology model TGAACAATCGATTAAA Region 14-65 · 1 3D model Open · Scan
TFS_sp_A6NFD8_HELT_HUMAN:14:65_4atk_B_1 ModCRE Homology model GGCCCAATATTTTTAG Region 14-65 · 1 3D model Open · Scan
TFS_sp_A6NFD8_HELT_HUMAN:15:65_4ati_A_1 ModCRE Homology model CTGACAATCTGGGGTT Region 15-65 · 1 3D model Open · Scan
TFS_sp_A6NFD8_HELT_HUMAN:15:69_1an4_A_1 ModCRE Homology model AGGCCGTGTCGGGCACATCC Region 15-69 · 1 3D model Open · Scan
TFS_sp_A6NFD8_HELT_HUMAN:15:69_1an4_B_1 ModCRE Homology model TGGGATCATCGTGGGGGCCT Region 15-69 · 1 3D model Open · Scan
TFS_sp_A6NFD8_HELT_HUMAN:9:68_4h10_A_1 ModCRE Homology model GAAGCACGGGCCCA Region 9-68 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 242 aa
4-69

Region 4-69 11 PWM

Residues
66 aa
Domains
PF00010 · Helix-loop-helix DNA-binding domain
3D models
18 active PDBs · 10 summary rows
Templates
1A0A, 1AN4, 1HLO, 1MDY, 4ATI, 4ATK, 4H10, 8OSJ, ...
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
18 active PDB models 10 summary rows
Region 4-6918 models · 10 summary rows
Actions
Predicted = Low DIMER_sp_A6NFD8_HELT_HUMAN:14:62_8osk_N_1 8osk 14-62 View model · PDB
Predicted = Low DIMER_sp_A6NFD8_HELT_HUMAN:14:62_8osl_P_1 8osl 14-62 View model · PDB
Predicted = Low DIMER_sp_A6NFD8_HELT_HUMAN:15:63_1hlo_A_1 1hlo 15-63 View model · PDB
Predicted = Low DIMER_sp_A6NFD8_HELT_HUMAN:4:67_1mdy_A_1 1mdy 4-67 View model · PDB
Predicted = Low DIMER_sp_A6NFD8_HELT_HUMAN:9:62_8osj_N_1 8osj 9-62 View model · PDB
Predicted = Low DIMER_sp_A6NFD8_HELT_HUMAN:9:62_8osl_N_1 8osl 9-62 View model · PDB
Predicted = Low DIMER_sp_A6NFD8_HELT_HUMAN:9:68_4h10_A_1 4h10 9-68 View model · PDB
Predicted = Low TFS_sp_A6NFD8_HELT_HUMAN:14:62_8osk_N_1 8osk 14-62 View model · PDB
Predicted = Low TFS_sp_A6NFD8_HELT_HUMAN:14:62_8osl_P_1 8osl 14-62 View model · PDB
Predicted = Low TFS_sp_A6NFD8_HELT_HUMAN:14:65_1a0a_A_1 1a0a 14-65 View model · PDB
Predicted = Low TFS_sp_A6NFD8_HELT_HUMAN:14:65_4atk_A_1 4atk 14-65 View model · PDB
Predicted = Low TFS_sp_A6NFD8_HELT_HUMAN:14:65_4atk_B_1 4atk 14-65 View model · PDB
Predicted = Low TFS_sp_A6NFD8_HELT_HUMAN:15:65_4ati_A_1 4ati 15-65 View model · PDB
Predicted = Low TFS_sp_A6NFD8_HELT_HUMAN:15:69_1an4_A_1 1an4 15-69 View model · PDB
Predicted = Low TFS_sp_A6NFD8_HELT_HUMAN:15:69_1an4_B_1 1an4 15-69 View model · PDB
Predicted = Low TFS_sp_A6NFD8_HELT_HUMAN:9:62_8osj_N_1 8osj 9-62 View model · PDB
Predicted = Low TFS_sp_A6NFD8_HELT_HUMAN:9:62_8osl_N_1 8osl 9-62 View model · PDB
Predicted = Low TFS_sp_A6NFD8_HELT_HUMAN:9:68_4h10_A_1 4h10 9-68 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
3 8osl 4:79 13,14 63,62 P:O,P · DNA:I,J 44.9% / 63.3% 80,94 View · PDB TFS_sp_A6NFD8_HELT_HUMAN:14:62_8osl_P_1
3 8osl 4:79 13,14 63,62 P:O,P · DNA:I,J 44.9% / 63.3% 80,94 View · PDB DIMER_sp_A6NFD8_HELT_HUMAN:14:62_8osl_P_1
4 8osk 4:79 9,14 63,62 P:M,N · DNA:I,J 44.9% / 63.3% 15,16 View · PDB TFS_sp_A6NFD8_HELT_HUMAN:14:62_8osk_N_1
4 8osk 4:79 9,14 63,62 P:M,N · DNA:I,J 44.9% / 63.3% 15,16 View · PDB DIMER_sp_A6NFD8_HELT_HUMAN:14:62_8osk_N_1
2 8osj 4:79 9,9 63,62 P:M,N · DNA:I,J 42.6% / 59.3% 79,96 View · PDB TFS_sp_A6NFD8_HELT_HUMAN:9:62_8osj_N_1
2 8osj 4:79 9,9 63,62 P:M,N · DNA:I,J 42.6% / 59.3% 79,96 View · PDB DIMER_sp_A6NFD8_HELT_HUMAN:9:62_8osj_N_1
5 8osl 4:79 9,14 62,62 P:N,P · DNA:I,J 42.6% / 59.3% 17,94 View · PDB TFS_sp_A6NFD8_HELT_HUMAN:9:62_8osl_N_1
5 8osl 4:79 9,14 62,62 P:N,P · DNA:I,J 42.6% / 59.3% 17,94 View · PDB DIMER_sp_A6NFD8_HELT_HUMAN:9:62_8osl_N_1
1 4h10 4:79 9,9 68,63 P:A,B · DNA:C,D 41.7% / 58.3% 96,79 View · PDB TFS_sp_A6NFD8_HELT_HUMAN:9:68_4h10_A_1
1 4h10 4:79 9,9 68,63 P:A,B · DNA:C,D 41.7% / 58.3% 96,79 View · PDB DIMER_sp_A6NFD8_HELT_HUMAN:9:68_4h10_A_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
14-65PF00010Helix-loop-helix DNA-binding domainoverlaps 4-69
86-126PF07527Hairy OrangeNo overlap with loaded model regions