Transcription factor

C8CJL6 - ESR1

Estrogen receptor alpha delta 4 +49 isoform

Homo sapiens (Human) · Unreviewed (UniProtKB/TrEMBL) · 222 aa

92 Generated PWM 12 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)80

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
MA0112.1	NN 70-40%	JASPAR	CCAGGTCACCGTGACCCC	65.4% identity		Open · Scan
M09309_2.00	NN 70-40%	CisBP	AGGTCAGGGTGACCT	64.5% identity		Open · Scan
MA0859.1	NN 70-40%	JASPAR	AAGGTCAAAAGGTCAA	61.0% identity		Open · Scan
MA1553.1	NN 70-40%	JASPAR	AAGGTCATGACCTT	61.0% identity		Open · Scan
M03424_2.00	NN 70-40%	CisBP	AAAGGTCACCAGAGGTCA	59.3% identity		Open · Scan
M05563_2.00	NN 70-40%	CisBP	AAAAGGTCAA	59.3% identity		Open · Scan
MA0159.1	NN 70-40%	JASPAR	AGGTCACGGAGAGGTCA	59.3% identity		Open · Scan
MA0857.1	NN 70-40%	JASPAR	AAAGGTCAAAAGGTCA	59.3% identity		Open · Scan
MA1552.1	NN 70-40%	JASPAR	AAGGTCATGACCTT	59.3% identity		Open · Scan
M00371_2.00	NN 70-40%	CisBP	ACTTAATATATAC	58.3% identity		Open · Scan
MA0007.1	NN 70-40%	JASPAR	ATAAGAACACCCTGTACCCGCC	58.3% identity		Open · Scan
MA0007.2	NN 70-40%	JASPAR	AAGAACAGAATGTTC	58.3% identity		Open · Scan
MA0007.3	NN 70-40%	JASPAR	GGGAACACGGTGTACCC	58.3% identity		Open · Scan
M00811_2.00	NN 70-40%	CisBP	AAAGGTCAAG	57.6% identity		Open · Scan
M03432_2.00	NN 70-40%	CisBP	AAAGGTCAAGAGAGGTCA	57.6% identity		Open · Scan
M03939_2.00	NN 70-40%	CisBP	TAAAGGTCA	56.1% identity		Open · Scan
M05886_2.00	NN 70-40%	CisBP	AGTACATTTTGTTCT	56.1% identity		Open · Scan
M06417_2.00	NN 70-40%	CisBP	CAGTCCGAAGGTCACCGC	56.1% identity		Open · Scan
M07987_2.00	NN 70-40%	CisBP	GCCCAGAACATTCTGTTCCCT	56.1% identity		Open · Scan
MA0071.1	NN 70-40%	JASPAR	ATCAAGGTCA	56.1% identity		Open · Scan
MA0113.1	NN 70-40%	JASPAR	GGGAACATTATGTCCTAA	56.1% identity		Open · Scan
MA0160.1	NN 70-40%	JASPAR	AAGGTCAC	56.1% identity		Open · Scan
MA0727.1	NN 70-40%	JASPAR	GGGAACACAATGTTCCC	56.1% identity		Open · Scan
M02392_2.00	NN 70-40%	CisBP	GAGGTCAA	55.9% identity		Open · Scan
MA0677.1	NN 70-40%	JASPAR	GAGGTCAAAGGTCA	55.9% identity		Open · Scan
MA1539.1	NN 70-40%	JASPAR	AAGGTCACTGACCTT	55.9% identity		Open · Scan
M09609_2.00	NN 70-40%	CisBP	CCAGGAACAG	54.5% identity		Open · Scan
M00820_2.00	NN 70-40%	CisBP	TAGGTCACC	54.3% identity		Open · Scan
M00822_2.00	NN 70-40%	CisBP	GAGGTCAC	54.3% identity		Open · Scan
M01298_2.00	NN 70-40%	CisBP	AAAGGTCA	54.3% identity		Open · Scan
M02393_2.00	NN 70-40%	CisBP	AGAGGTCAC	54.3% identity		Open · Scan
M02400_2.00	NN 70-40%	CisBP	GGGGTCAC	54.3% identity		Open · Scan
M03435_2.00	NN 70-40%	CisBP	GGGGTCAAAGGTCA	54.3% identity		Open · Scan
M05661_2.00	NN 70-40%	CisBP	GGGGTCAAAGGTCAG	54.3% identity		Open · Scan
M05669_2.00	NN 70-40%	CisBP	GAGGTCAT	54.3% identity		Open · Scan
MA0017.1	NN 70-40%	JASPAR	TGACCTTTGAACCT	54.3% identity		Open · Scan
MA0504.1	NN 70-40%	JASPAR	AGGGGTCAGAGGTCA	54.3% identity		Open · Scan
MA0855.1	NN 70-40%	JASPAR	GGGGTCAAAGGTCA	54.3% identity		Open · Scan
MA0856.1	NN 70-40%	JASPAR	GGGGTCAAAGGTCA	54.3% identity		Open · Scan
MA1111.1	NN 70-40%	JASPAR	CAAAGGTCAAA	54.3% identity		Open · Scan
MA1150.1	NN 70-40%	JASPAR	AATTAGGTCAC	54.3% identity		Open · Scan
M00814_2.00	NN 70-40%	CisBP	AAAGTCAAAT	54.0% identity		Open · Scan
M02408_2.00	NN 70-40%	CisBP	TGAGGTCAATTT	54.0% identity		Open · Scan
MA0676.1	NN 70-40%	JASPAR	AAAAGTCAA	54.0% identity		Open · Scan
M03927_2.00	NN 70-40%	CisBP	GAAACTAGAGCA	52.9% identity		Open · Scan
M09277_2.00	NN 70-40%	CisBP	GGGGGATCAAGAGGTCAAGG	52.9% identity		Open · Scan
M02388_2.00	NN 70-40%	CisBP	GAGGTCA	52.6% identity		Open · Scan
M03421_2.00	NN 70-40%	CisBP	GGGGTCAAAGGTCA	52.6% identity		Open · Scan
M05590_2.00	NN 70-40%	CisBP	TTCAAGGTCAC	52.6% identity		Open · Scan
M06413_2.00	NN 70-40%	CisBP	AAATAGGTCA	52.6% identity		Open · Scan
M09616_2.00	NN 70-40%	CisBP	TTCAAGGTCA	52.6% identity		Open · Scan
M11192_2.00	NN 70-40%	CisBP	GGGGTCACG	52.6% identity		Open · Scan
MA0065.1	NN 70-40%	JASPAR	CCAGGGGTCAAAGGTCATCG	52.6% identity		Open · Scan
MA0065.2	NN 70-40%	JASPAR	GTAGGGCAAAGGTCA	52.6% identity		Open · Scan
MA0505.1	NN 70-40%	JASPAR	AAGTTCAAGGTCAGC	52.6% identity		Open · Scan
MA1540.1	NN 70-40%	JASPAR	GTCAAGGTCAC	52.6% identity		Open · Scan
MA0115.1	NN 70-40%	JASPAR	AAAGGTCAAAGGTCAAC	52.5% identity		Open · Scan
MA0484.1	NN 70-40%	JASPAR	AGAGTCCAAAGTCCA	52.5% identity		Open · Scan
M03382_2.00	NN 70-40%	CisBP	GGGAACACAATGTTCCC	52.4% identity		Open · Scan
M03392_2.00	NN 70-40%	CisBP	AAGGTCAACTAAAGGTCA	52.0% identity		Open · Scan
M05660_2.00	NN 70-40%	CisBP	GATGTGGGTCAGTGGGTCAG	51.7% identity		Open · Scan
MA1110.1	NN 70-40%	JASPAR	TCAATGACCTA	51.7% identity		Open · Scan
MA1531.1	NN 70-40%	JASPAR	GGGTCAGTAGGTCAG	51.7% identity		Open · Scan
MA1532.1	NN 70-40%	JASPAR	GGGTTAGTGGGTCAT	51.7% identity		Open · Scan
M02409_2.00	NN 70-40%	CisBP	GAGATCAA	51.6% identity		Open · Scan
M06432_2.00	NN 70-40%	CisBP	AAAAATCAAAGGT	51.6% identity		Open · Scan
M05635_2.00	NN 70-40%	CisBP	GTGACCTCAATGAGGTCAC	51.0% identity		Open · Scan
M00690_2.00	NN 70-40%	CisBP	AAAGATCAAA	50.8% identity		Open · Scan
M00812_2.00	NN 70-40%	CisBP	AGAGGTCACG	50.8% identity		Open · Scan
M02405_2.00	NN 70-40%	CisBP	AGAGGTCAGT	50.8% identity		Open · Scan
M05599_2.00	NN 70-40%	CisBP	AAAGGTCAA	50.8% identity		Open · Scan
M05621_2.00	NN 70-40%	CisBP	TAGGTCATGACCTA	50.8% identity		Open · Scan
M11139_2.00	NN 70-40%	CisBP	AAGTAGGTCACCGTGACCTACTT	50.8% identity		Open · Scan
MA0494.1	NN 70-40%	JASPAR	TGACCTAAAGTAACCTCTG	50.8% identity		Open · Scan
MA1148.1	NN 70-40%	JASPAR	ATGTAGGTCAAAGGTCAT	50.8% identity		Open · Scan
MA1151.1	NN 70-40%	JASPAR	ATAAGTAGGTCA	50.8% identity		Open · Scan
MA1535.1	NN 70-40%	JASPAR	CGAGGTCAC	50.8% identity		Open · Scan
MA1541.1	NN 70-40%	JASPAR	GTCAAGTTCAAGGTCAA	50.8% identity		Open · Scan
M09283_2.00	NN 70-40%	CisBP	TGAGGTCAAAAAAGTTCAG	50.0% identity		Open · Scan
MA1533.1	NN 70-40%	JASPAR	ATGAACTCGATGAACTC	50.0% identity		Open · Scan

ModCRE12

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:57_1lat_A_1	ModCRE	Homology model	AAAAAGTCAAAACTTTTT	Region 1-57 · 1 3D model		Open · Scan
DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:57_4oln_A_1	ModCRE	Homology model	AAAGGTCAATTTGACCTTT	Region 1-57 · 1 3D model		Open · Scan
DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:58_4aa6_B_1	ModCRE	Homology model	AAGGTCAATTTGACCTT	Region 1-58 · 1 3D model		Open · Scan
DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:59_1hcq_B_1	ModCRE	Homology model	AGGGTCATTTTGACCTT	Region 1-59 · 1 3D model		Open · Scan
DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:60_1r4i_B_1	ModCRE	Homology model	AAGGTCACATTGACCTTT	Region 1-60 · 1 3D model		Open · Scan
DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:60_4ond_A_1	ModCRE	Homology model	AAGGTCAAAGTGACCTT	Region 1-60 · 1 3D model		Open · Scan
DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:61_8ifo_A_1	ModCRE	Homology model	ATTTGACCTTTGACCTT	Region 1-61 · 1 3D model		Open · Scan
TFS_tr_C8CJL6_C8CJL6_HUMAN:1:58_4aa6_B_1	ModCRE	Homology model	AAGGTCAAATTGACCTT	Region 1-58 · 1 3D model		Open · Scan
TFS_tr_C8CJL6_C8CJL6_HUMAN:1:59_1hcq_B_1	ModCRE	Homology model	AAGGTCAAATTGACCTT	Region 1-59 · 1 3D model		Open · Scan
TFS_tr_C8CJL6_C8CJL6_HUMAN:1:60_1r4i_B_1	ModCRE	Homology model	AAAGGTCAATTTGACCTT	Region 1-60 · 1 3D model		Open · Scan
TFS_tr_C8CJL6_C8CJL6_HUMAN:1:61_1lo1_A_1	ModCRE	Homology model	ATGTACCTTTTAG	Region 1-61 · 1 3D model		Open · Scan
TFS_tr_C8CJL6_C8CJL6_HUMAN:1:61_8ifo_A_1	ModCRE	Homology model	AAGGTCAAAGGTCAATA	Region 1-61 · 1 3D model		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 222 aa

1-61

Region 1-61 12 PWM

Residues

61 aa

Domains

PF00105 · Double treble clef zinc finger, C4 type PF00104 · Ligand-binding domain of nuclear hormone receptor

3D models

12 active PDBs · 10 summary rows

Templates

1HCQ, 1LAT, 1LO1, 1R4I, 4AA6, 4OLN, 4OND, 8IFO

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

12 active PDB models 10 summary rows

Region 1-6112 models · 10 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:57_1lat_A_1	1lat	1-57	View model · PDB
Predicted = Low	DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:57_4oln_A_1	4oln	1-57	View model · PDB
Predicted = Low	DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:58_4aa6_B_1	4aa6	1-58	View model · PDB
Predicted = Low	DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:59_1hcq_B_1	1hcq	1-59	View model · PDB
Predicted = Low	DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:60_1r4i_B_1	1r4i	1-60	View model · PDB
Predicted = Low	DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:60_4ond_A_1	4ond	1-60	View model · PDB
Predicted = Low	DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:61_8ifo_A_1	8ifo	1-61	View model · PDB
Predicted = Low	TFS_tr_C8CJL6_C8CJL6_HUMAN:1:58_4aa6_B_1	4aa6	1-58	View model · PDB
Predicted = Low	TFS_tr_C8CJL6_C8CJL6_HUMAN:1:59_1hcq_B_1	1hcq	1-59	View model · PDB
Predicted = Low	TFS_tr_C8CJL6_C8CJL6_HUMAN:1:60_1r4i_B_1	1r4i	1-60	View model · PDB
Predicted = Low	TFS_tr_C8CJL6_C8CJL6_HUMAN:1:61_1lo1_A_1	1lo1	1-61	View model · PDB
Predicted = Low	TFS_tr_C8CJL6_C8CJL6_HUMAN:1:61_8ifo_A_1	8ifo	1-61	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
1	1hcq	1:61	1,1	59,59	P:A,B · DNA:C,D	100.0% / 100.0%	79,83	View · PDB TFS_tr_C8CJL6_C8CJL6_HUMAN:1:59_1hcq_B_1
1	1hcq	1:61	1,1	59,59	P:A,B · DNA:C,D	100.0% / 100.0%	79,83	View · PIR DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:59_1hcq_B_1
2	4aa6	1:61	1,1	58,58	P:A,B · DNA:C,D	98.3% / 98.3%	82,82	View · PDB TFS_tr_C8CJL6_C8CJL6_HUMAN:1:58_4aa6_B_1
2	4aa6	1:61	1,1	58,58	P:A,B · DNA:C,D	98.3% / 98.3%	82,82	View · PIR DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:58_4aa6_B_1
3	8ifo	1:61	1,1	61,61	P:A,B · DNA:C,D	72.1% / 82.0%	80,76	View · PDB TFS_tr_C8CJL6_C8CJL6_HUMAN:1:61_8ifo_A_1
3	8ifo	1:61	1,1	61,61	P:A,B · DNA:C,D	72.1% / 82.0%	80,76	View · PDB DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:61_8ifo_A_1
4	1lo1	1:61	1	61	P:A · DNA:B,C	70.5% / 80.3%	67	View · PDB TFS_tr_C8CJL6_C8CJL6_HUMAN:1:61_1lo1_A_1
5	1lat	1:61	1,1	57,57	P:A,B · DNA:C,D	59.6% / 77.2%	80,77	View · PDB DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:57_1lat_A_1
4	1r4i	1:61	1,1	60,60	P:A,B · DNA:C,D	58.3% / 70.0%	81,84	View · PDB DIMER_tr_C8CJL6_C8CJL6_HUMAN:1:60_1r4i_B_1
5	1r4i	1:61	1,1	60,60	P:A,B · DNA:C,D	58.3% / 70.0%	81,84	View · PDB TFS_tr_C8CJL6_C8CJL6_HUMAN:1:60_1r4i_B_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
1-59	PF00105	Double treble clef zinc finger, C4 type	overlaps 1-61
61-212	PF00104	Ligand-binding domain of nuclear hormone receptor	overlaps 1-61