ModCRE DB

Transcription factor

E9PB28 - HES4

Hes family bHLH transcription factor 4

Homo sapiens (Human) · Unreviewed (UniProtKB/TrEMBL) · 247 aa

10 Generated PWM 13 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)6
MotifPredictionSourceDNA bindingSupportLogoActions
MA1099.2 NN 70-40% JASPAR GGCACGTGGC 59.1% identity Open · Scan
MA1099.1 NN 70-40% JASPAR GGCACGCGTC 55.6% identity Open · Scan
M09656_2.00 NN 70-40% CisBP GGCACGCGCC 55.2% identity Open · Scan
M05959_2.00 NN 70-40% CisBP GGCACGTGCCA 53.3% identity Open · Scan
M03596_2.00 NN 70-40% CisBP TTGGCACGTGCCAT 51.8% identity Open · Scan
MA0616.1 NN 70-40% JASPAR TAACGACACGTGC 51.8% identity Open · Scan
ModCRE4
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_tr_E9PB28_E9PB28_HUMAN:60:104_1hlo_A_1 ModCRE Homology model ACACGCGCGGG Region 60-104 · 1 3D model Open · Scan
DIMER_tr_E9PB28_E9PB28_HUMAN:67:124_4ati_A_1 ModCRE Homology model GGCCACACATTTGTCT Region 67-124 · 1 3D model Open · Scan
DIMER_tr_E9PB28_E9PB28_HUMAN:67:124_4atk_B_1 ModCRE Homology model GGCCAAAGATTTGTGT Region 67-124 · 1 3D model Open · Scan
TFS_tr_E9PB28_E9PB28_HUMAN:60:88_1am9_D_1 ModCRE Homology model CAGCTCCCCCGGGCGGGTTAGTAA Region 60-88 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 247 aa
60-124

Region 60-124 4 PWM

Residues
65 aa
Domains
PF00010 · Helix-loop-helix DNA-binding domain
3D models
13 active PDBs · 10 summary rows
Templates
1AM9, 1HLO, 4ATI, 4ATK, 4H10
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
13 active PDB models 10 summary rows
Region 60-12413 models · 10 summary rows
Actions
Predicted = Low DIMER_tr_E9PB28_E9PB28_HUMAN:60:104_1hlo_A_1 1hlo 60-104 View model · PDB
Predicted = Low DIMER_tr_E9PB28_E9PB28_HUMAN:60:88_1am9_A_1 1am9 60-88 View model · PDB
Predicted = Low DIMER_tr_E9PB28_E9PB28_HUMAN:60:88_1am9_B_1 1am9 60-88 View model · PDB
Predicted = Low DIMER_tr_E9PB28_E9PB28_HUMAN:60:88_1am9_C_1 1am9 60-88 View model · PDB
Predicted = Low DIMER_tr_E9PB28_E9PB28_HUMAN:60:88_1am9_D_1 1am9 60-88 View model · PDB
Predicted = Low DIMER_tr_E9PB28_E9PB28_HUMAN:67:124_4ati_A_1 4ati 67-124 View model · PDB
Predicted = Low DIMER_tr_E9PB28_E9PB28_HUMAN:67:124_4atk_B_1 4atk 67-124 View model · PDB
Predicted = Low TFS_tr_E9PB28_E9PB28_HUMAN:60:88_1am9_A_1 1am9 60-88 View model · PDB
Predicted = Low TFS_tr_E9PB28_E9PB28_HUMAN:60:88_1am9_B_1 1am9 60-88 View model · PDB
Predicted = Low TFS_tr_E9PB28_E9PB28_HUMAN:60:88_1am9_D_1 1am9 60-88 View model · PDB
Predicted = Low TFS_tr_E9PB28_E9PB28_HUMAN:67:124_4ati_A_1 4ati 67-124 View model · PDB
Predicted = Low TFS_tr_E9PB28_E9PB28_HUMAN:67:124_4atk_B_1 4atk 67-124 View model · PDB
Predicted = Low TFS_tr_E9PB28_E9PB28_HUMAN:68:118_4h10_A_1 4h10 68-118 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
2 4atk 60:124 67,67 124,124 P:A,B · DNA:C,D 34.5% / 56.9% 86,90 View · PDB DIMER_tr_E9PB28_E9PB28_HUMAN:67:124_4atk_B_1
3 4atk 60:124 67,67 124,124 P:A,B · DNA:C,D 34.5% / 56.9% 86,90 View · PDB TFS_tr_E9PB28_E9PB28_HUMAN:67:124_4atk_B_1
1 4ati 60:124 67,67 124,124 P:A,B · DNA:C,D 34.5% / 55.2% 87,74 View · PDB TFS_tr_E9PB28_E9PB28_HUMAN:67:124_4ati_A_1
1 4ati 60:124 67,67 124,124 P:A,B · DNA:C,D 34.5% / 55.2% 87,74 View · PDB DIMER_tr_E9PB28_E9PB28_HUMAN:67:124_4ati_A_1
2 4h10 60:124 68 118 P:A · DNA:C,D 33.3% / 62.7% 78 View · PDB TFS_tr_E9PB28_E9PB28_HUMAN:68:118_4h10_A_1
3 1am9 60:124 60,60 88,88 P:B,D · DNA:E,F,G,H 31.0% / 69.0% 38,38 View · PDB DIMER_tr_E9PB28_E9PB28_HUMAN:60:88_1am9_B_1
4 1am9 60:124 60,60 88,88 P:B,D · DNA:E,F,G,H 31.0% / 69.0% 38,38 View · PDB TFS_tr_E9PB28_E9PB28_HUMAN:60:88_1am9_B_1
4 1am9 60:124 60,60 88,88 P:A,D · DNA:E,F,G,H 31.0% / 69.0% 36,38 View · PDB DIMER_tr_E9PB28_E9PB28_HUMAN:60:88_1am9_A_1
5 1am9 60:124 60,60 88,88 P:A,D · DNA:E,F,G,H 31.0% / 69.0% 36,38 View · PDB TFS_tr_E9PB28_E9PB28_HUMAN:60:88_1am9_A_1
5 1am9 60:124 60,60 88,88 P:C,D · DNA:E,F,G,H 31.0% / 69.0% 35,38 View · PDB DIMER_tr_E9PB28_E9PB28_HUMAN:60:88_1am9_C_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
64-118PF00010Helix-loop-helix DNA-binding domainoverlaps 60-124
135-174PF07527Hairy OrangeNo overlap with loaded model regions