ModCRE DB

Transcription factor

O14503 - BHLHE40

Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 412 aa

9 Generated PWM 1 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known9
MotifPredictionSourceDNA bindingSupportLogoActions
MA0464.2 Known JASPAR ATCACGTGAC Direct PWM Open · Scan
MA0464.3 Known JASPAR TCACGTGA Direct PWM Open · Scan
M02788_2.00 Known CisBP ATCACGTGAC Direct PWM Open · Scan
M04126_2.00 Known CisBP GTCACGTGAC Direct PWM Open · Scan
M04127_2.00 Known CisBP GTCACGTGAC Direct PWM Open · Scan
M07798_2.00 Known CisBP GCACGTGACC Direct PWM Open · Scan
M08726_2.00 Known CisBP GGCACGTGAC Direct PWM Open · Scan
M09456_2.00 Known CisBP GCACGTGCCT Direct PWM Open · Scan
BHE40_HUMAN.H11MO.0.A Known HOCOMOCO GGCACGTGAC Direct PWM Open · Scan
Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)0

No generated PWM in this category.

ModCRE0

No generated PWM in this category.

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 412 aa
49-125

Region 49-125 0 PWM

Residues
77 aa
Domains
PF00010 · Helix-loop-helix DNA-binding domain
3D models
1 active PDB
Templates
1AM9
Sources
Structure model
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
1 active PDB model
Region 49-1251 model
Actions
Predicted = Low DIMER_O14503:49:125_1am9_B_1 1am9 49-125 View model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
55-107PF00010Helix-loop-helix DNA-binding domainoverlaps 49-125
141-179PF07527Hairy OrangeNo overlap with loaded model regions