ModCRE DB

Transcription factor

O43711 - TLX3

T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 291 aa

112 Generated PWM 12 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known4
MotifPredictionSourceDNA bindingSupportLogoActions
M05233_2.00 Known CisBP TAATTGCCGCGATTAAGAGCAATTA Direct PWM Open · Scan
M05234_2.00 Known CisBP TAATTGATTATAAAAAGCAATTA Direct PWM Open · Scan
M05235_2.00 Known CisBP GAATTGCTCTTTAGAGCAATTC Direct PWM Open · Scan
M05236_2.00 Known CisBP TAATTGGTTAAAATTCAATTA Direct PWM Open · Scan
Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)98
MotifPredictionSourceDNA bindingSupportLogoActions
M06290_2.00 NN 70-40% CisBP TTTAATTA 68.4% identity Open · Scan
MA1577.1 NN 70-40% JASPAR CTAATTAG 63.3% identity Open · Scan
M09573_2.00 NN 70-40% CisBP GTTAATGA 62.5% identity Open · Scan
MA0674.1 NN 70-40% JASPAR GTAATTAA 62.5% identity Open · Scan
MA0675.1 NN 70-40% JASPAR CTAATTAA 61.2% identity Open · Scan
MA0896.1 NN 70-40% JASPAR ACAAGCAATTAATGAAT 61.1% identity Open · Scan
M00526_2.00 NN 70-40% CisBP ATTAATTA 61.0% identity Open · Scan
MA0635.1 NN 70-40% JASPAR GCTAAACGGT 60.0% identity Open · Scan
MA0877.1 NN 70-40% JASPAR GCTAATTGCT 60.0% identity Open · Scan
MA0877.2 NN 70-40% JASPAR CTAAACGG 60.0% identity Open · Scan
M05392_2.00 NN 70-40% CisBP GTTAAGTGC 59.7% identity Open · Scan
MA1530.1 NN 70-40% JASPAR CTCATTAAA 59.6% identity Open · Scan
M02106_2.00 NN 70-40% CisBP ATATTAATTGGTT 59.3% identity Open · Scan
M03234_2.00 NN 70-40% CisBP TTTTAATTGGT 59.0% identity Open · Scan
MA0897.1 NN 70-40% JASPAR ACAAGCAATTAAAGAAT 59.0% identity Open · Scan
M02165_2.00 NN 70-40% CisBP CTTAATTGG 58.8% identity Open · Scan
MA0618.1 NN 70-40% JASPAR TTAATTAG 58.4% identity Open · Scan
M06554_2.00 NN 70-40% CisBP TTAATTG 58.2% identity Open · Scan
M10754_2.00 NN 70-40% CisBP CAAGTGCGTG 58.2% identity Open · Scan
MA0898.1 NN 70-40% JASPAR ACAAGCAATTAAAGAAT 58.2% identity Open · Scan
M00497_2.00 NN 70-40% CisBP TTAAGTGGT 58.0% identity Open · Scan
M03810_2.00 NN 70-40% CisBP GCTAAACGGT 58.0% identity Open · Scan
M05042_2.00 NN 70-40% CisBP GTCAAGTGGT 58.0% identity Open · Scan
MA0119.1 NN 70-40% JASPAR TGGCACCATGCCAA 58.0% identity Open · Scan
MA0672.1 NN 70-40% JASPAR ACCACTTGAA 58.0% identity Open · Scan
M06361_2.00 NN 70-40% CisBP TTTAATTA 57.8% identity Open · Scan
MA0124.1 NN 70-40% JASPAR ATACTTA 57.8% identity Open · Scan
MA0124.2 NN 70-40% JASPAR ACCACTTAA 57.8% identity Open · Scan
M02210_2.00 NN 70-40% CisBP AAGTACTTAA 56.8% identity Open · Scan
M06323_2.00 NN 70-40% CisBP ATTAATTG 56.6% identity Open · Scan
MA0063.1 NN 70-40% JASPAR TTAATTG 56.6% identity Open · Scan
MA0063.2 NN 70-40% JASPAR ACCACTCAAAA 56.6% identity Open · Scan
MA0122.1 NN 70-40% JASPAR TTAAGTGGA 56.6% identity Open · Scan
MA0122.2 NN 70-40% JASPAR ACCACTTAA 56.6% identity Open · Scan
M03815_2.00 NN 70-40% CisBP TTAATTAG 55.7% identity Open · Scan
M00462_2.00 NN 70-40% CisBP CTAATTG 55.5% identity Open · Scan
M06312_2.00 NN 70-40% CisBP TTAATTA 55.5% identity Open · Scan
MA0889.1 NN 70-40% JASPAR ACTAATTAGC 55.5% identity Open · Scan
MA0890.1 NN 70-40% JASPAR ACCAATTAGC 55.5% identity Open · Scan
MA0699.1 NN 70-40% JASPAR GCCAATTAGC 55.3% identity Open · Scan
M02150_2.00 NN 70-40% CisBP TTAATTAA 54.9% identity Open · Scan
M06489_2.00 NN 70-40% CisBP TTAATTA 54.7% identity Open · Scan
M10805_2.00 NN 70-40% CisBP GGACAAATAGCCC 54.5% identity Open · Scan
M03777_2.00 NN 70-40% CisBP GTAATTGC 54.3% identity Open · Scan
M06539_2.00 NN 70-40% CisBP CTAATTA 54.2% identity Open · Scan
M01244_2.00 NN 70-40% CisBP ATTAATTAC 54.0% identity Open · Scan
M02148_2.00 NN 70-40% CisBP CTAATTAG 53.9% identity Open · Scan
M00465_2.00 NN 70-40% CisBP TTAATTAG 53.8% identity Open · Scan
M02107_2.00 NN 70-40% CisBP TTAATTGCT 53.7% identity Open · Scan
M02179_2.00 NN 70-40% CisBP GCTAATTAC 53.7% identity Open · Scan
M02205_2.00 NN 70-40% CisBP CATTAATTACC 53.7% identity Open · Scan
M06359_2.00 NN 70-40% CisBP TTTAATTA 53.7% identity Open · Scan
M09181_2.00 NN 70-40% CisBP TTTAATTGTTTT 53.7% identity Open · Scan
M09582_2.00 NN 70-40% CisBP ATGATTGATG 53.7% identity Open · Scan
MA0875.1 NN 70-40% JASPAR GCAATTAG 53.7% identity Open · Scan
M06545_2.00 NN 70-40% CisBP TTAATTA 53.5% identity Open · Scan
M06548_2.00 NN 70-40% CisBP TTAATTG 53.4% identity Open · Scan
M09195_2.00 NN 70-40% CisBP TAATTATAGGT 53.4% identity Open · Scan
MA1476.1 NN 70-40% JASPAR GCAATTAC 53.4% identity Open · Scan
M06232_2.00 NN 70-40% CisBP TTAATGA 53.3% identity Open · Scan
MA0876.1 NN 70-40% JASPAR CCAATTAA 53.3% identity Open · Scan
MA0673.1 NN 70-40% JASPAR CCACTTGAA 53.2% identity Open · Scan
M03798_2.00 NN 70-40% CisBP GGTAATTAGC 52.7% identity Open · Scan
M02164_2.00 NN 70-40% CisBP GTAATGGGCT 52.6% identity Open · Scan
MA0709.1 NN 70-40% JASPAR CCAATTAA 52.6% identity Open · Scan
M00520_2.00 NN 70-40% CisBP CTTAAGTGCT 52.4% identity Open · Scan
MA0885.1 NN 70-40% JASPAR GCAATTAA 52.4% identity Open · Scan
M00457_2.00 NN 70-40% CisBP TTAATTGCT 52.3% identity Open · Scan
M02170_2.00 NN 70-40% CisBP TTAATTAG 52.3% identity Open · Scan
MA1471.1 NN 70-40% JASPAR AAAAACCATTAC 52.3% identity Open · Scan
M00376_2.00 NN 70-40% CisBP TCAAGTGCTT 51.7% identity Open · Scan
M00492_2.00 NN 70-40% CisBP TAATTAGC 51.7% identity Open · Scan
M05100_2.00 NN 70-40% CisBP TTAACGAC 51.7% identity Open · Scan
M06286_2.00 NN 70-40% CisBP CTTAAGTG 51.7% identity Open · Scan
MA0900.1 NN 70-40% JASPAR CCTAATTACC 51.7% identity Open · Scan
MA0886.1 NN 70-40% JASPAR GCTAATTAGC 51.5% identity Open · Scan
M00496_2.00 NN 70-40% CisBP TTAAGTGGTT 51.4% identity Open · Scan
MA0710.1 NN 70-40% JASPAR GCTAATTAGC 50.9% identity Open · Scan
M00388_2.00 NN 70-40% CisBP CTAATTGCTT 50.8% identity Open · Scan
M01503_2.00 NN 70-40% CisBP TTAATTAC 50.8% identity Open · Scan
M04906_2.00 NN 70-40% CisBP ATAACGAC 50.8% identity Open · Scan
M05179_2.00 NN 70-40% CisBP ATAATTGC 50.8% identity Open · Scan
MA0666.1 NN 70-40% JASPAR CCAATTAG 50.8% identity Open · Scan
MA0707.1 NN 70-40% JASPAR GGTAATTAAA 50.8% identity Open · Scan
MA0708.1 NN 70-40% JASPAR CCAATTAA 50.8% identity Open · Scan
MA0879.1 NN 70-40% JASPAR CCTAATTATC 50.8% identity Open · Scan
MA0880.1 NN 70-40% JASPAR CCAATTAC 50.8% identity Open · Scan
MA0882.1 NN 70-40% JASPAR CCAATTAC 50.8% identity Open · Scan
M00464_2.00 NN 70-40% CisBP CTAATTACC 50.0% identity Open · Scan
M02149_2.00 NN 70-40% CisBP TCAAGTGCTT 50.0% identity Open · Scan
M03152_2.00 NN 70-40% CisBP TAATTAGCTAATTA 50.0% identity Open · Scan
M04959_2.00 NN 70-40% CisBP GTAATTAC 50.0% identity Open · Scan
M05027_2.00 NN 70-40% CisBP ATAATTAC 50.0% identity Open · Scan
M09196_2.00 NN 70-40% CisBP TTGATGGATG 50.0% identity Open · Scan
MA0612.1 NN 70-40% JASPAR CCTAATTACC 50.0% identity Open · Scan
MA0722.1 NN 70-40% JASPAR CTAATTAC 50.0% identity Open · Scan
MA0723.1 NN 70-40% JASPAR CTAATTAC 50.0% identity Open · Scan
MA1495.1 NN 70-40% JASPAR GTAATTAC 50.0% identity Open · Scan
ModCRE10
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_sp_O43711_TLX3_HUMAN:166:220_3rkq_B_1 ModCRE Homology model CTAATTGCCCCCCACTTAG Region 166-220 · 1 3D model Open · Scan
DIMER_sp_O43711_TLX3_HUMAN:170:220_4s0h_F_1 ModCRE Homology model TTTAGCCCAGAGATGTGGC Region 170-220 · 1 3D model Open · Scan
DIMER_sp_O43711_TLX3_HUMAN:170:224_2r5y_A_1 ModCRE Homology model GGCCCCAATAAATGACCCC Region 170-224 · 1 3D model Open · Scan
DIMER_sp_O43711_TLX3_HUMAN:170:227_1b72_A_1 ModCRE Homology model GGGGCAATTAATTGATTCC Region 170-227 · 1 3D model Open · Scan
DIMER_sp_O43711_TLX3_HUMAN:170:235_4uus_A_1 ModCRE Homology model GGTAATTAATTTT Region 170-235 · 1 3D model Open · Scan
TFS_sp_O43711_TLX3_HUMAN:152:228_3a01_A_1 ModCRE Homology model CCTCTAATTAATTATTT Region 152-228 · 1 3D model Open · Scan
TFS_sp_O43711_TLX3_HUMAN:165:223_2me6_A_1 ModCRE Homology model ATAAAAATTAGGAA Region 165-223 · 1 3D model Open · Scan
TFS_sp_O43711_TLX3_HUMAN:166:220_3rkq_B_1 ModCRE Homology model CTAATTGCCCACCACTTAG Region 166-220 · 1 3D model Open · Scan
TFS_sp_O43711_TLX3_HUMAN:166:230_1ahd_P_1 ModCRE Homology model GGGGCAAAATTTTG Region 166-230 · 1 3D model Open · Scan
TFS_sp_O43711_TLX3_HUMAN:167:224_4xic_A_1 ModCRE Homology model ACTTAATTGGCCCC Region 167-224 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 291 aa
152-235

Region 152-235 10 PWM

Residues
84 aa
Domains
PF00046 · Homeodomain
3D models
12 active PDBs · 10 summary rows
Templates
1AHD, 1B72, 2ME6, 2R5Y, 2R5Z, 3A01, 3RKQ, 4S0H, ...
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
12 active PDB models 10 summary rows
Region 152-23512 models · 10 summary rows
Actions
Predicted = Low DIMER_sp_O43711_TLX3_HUMAN:152:228_3a01_A_1 3a01 152-228 View model · PDB
Predicted = Low DIMER_sp_O43711_TLX3_HUMAN:166:220_3rkq_B_1 3rkq 166-220 View model · PDB
Predicted = Low DIMER_sp_O43711_TLX3_HUMAN:168:224_2r5z_A_1 2r5z 168-224 View model · PDB
Predicted = Low DIMER_sp_O43711_TLX3_HUMAN:170:220_4s0h_F_1 4s0h 170-220 View model · PDB
Predicted = Low DIMER_sp_O43711_TLX3_HUMAN:170:224_2r5y_A_1 2r5y 170-224 View model · PDB
Predicted = Low DIMER_sp_O43711_TLX3_HUMAN:170:227_1b72_A_1 1b72 170-227 View model · PDB
Predicted = Low DIMER_sp_O43711_TLX3_HUMAN:170:235_4uus_A_1 4uus 170-235 View model · PDB
Predicted = Low TFS_sp_O43711_TLX3_HUMAN:152:228_3a01_A_1 3a01 152-228 View model · PDB
Predicted = Low TFS_sp_O43711_TLX3_HUMAN:165:223_2me6_A_1 2me6 165-223 View model · PDB
Predicted = Low TFS_sp_O43711_TLX3_HUMAN:166:220_3rkq_B_1 3rkq 166-220 View model · PDB
Predicted = Low TFS_sp_O43711_TLX3_HUMAN:166:230_1ahd_P_1 1ahd 166-230 View model · PDB
Predicted = Low TFS_sp_O43711_TLX3_HUMAN:167:224_4xic_A_1 4xic 167-224 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
1 3a01 152:238 152,167 228,223 P:A,B · DNA:C,D 90.9% / 97.4% 98,100 View · PDB TFS_sp_O43711_TLX3_HUMAN:152:228_3a01_A_1
1 3a01 152:238 152,167 228,223 P:A,B · DNA:C,D 90.9% / 97.4% 98,100 View · PDB DIMER_sp_O43711_TLX3_HUMAN:152:228_3a01_A_1
2 3rkq 152:238 166,166 220,220 P:A,B · DNA:C,D 58.2% / 74.5% 94,96 View · PDB DIMER_sp_O43711_TLX3_HUMAN:166:220_3rkq_B_1
3 3rkq 152:238 166,166 220,220 P:A,B · DNA:C,D 58.2% / 74.5% 94,96 View · PDB TFS_sp_O43711_TLX3_HUMAN:166:220_3rkq_B_1
2 2me6 152:238 165 223 P:A · DNA:B,C 52.5% / 76.3% 83 View · PDB TFS_sp_O43711_TLX3_HUMAN:165:223_2me6_A_1
5 2r5y 152:238 170,190 224,223 P:A,B · DNA:C,D 49.1% / 69.1% 75,57 View · PDB DIMER_sp_O43711_TLX3_HUMAN:170:224_2r5y_A_1
3 1b72 152:238 170,190 227,230 P:A,B · DNA:D,E 48.3% / 69.0% 85,56 View · PDB DIMER_sp_O43711_TLX3_HUMAN:170:227_1b72_A_1
4 2r5z 152:238 168,190 224,223 P:A,B · DNA:C,D 47.4% / 68.4% 76,57 View · PDB DIMER_sp_O43711_TLX3_HUMAN:168:224_2r5z_A_1
5 4xic 152:238 167 224 P:A · DNA:B,C 44.8% / 67.2% 98 View · PDB TFS_sp_O43711_TLX3_HUMAN:167:224_4xic_A_1
4 1ahd 152:238 166 230 P:P · DNA:A,B 43.1% / 64.6% 95 View · PDB TFS_sp_O43711_TLX3_HUMAN:166:230_1ahd_P_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
167-223PF00046Homeodomainoverlaps 152-235