Transcription factor

O75475 - PSIP1

PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 530 aa

7 Generated PWM 8 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)0

No generated PWM in this category.

ModCRE7

Motif	Prediction	Source	DNA binding	Support	Actions
TFS_sp_O75475_PSIP1_HUMAN:1:91_8cbq_K_1	ModCRE	Homology model	ACCCCCGGCG	Region 1-91 · 1 3D model	Open · Scan
TFS_sp_O75475_PSIP1_HUMAN:1:91_8pc5_K_1	ModCRE	Homology model	ACGGGATCGGGTATCCACTTCACAGCGGATATTCTAGCACATCCCTAGGGTAACGATACGAGCCCACGGTTAGCATAGCCGTGACC	Region 1-91 · 1 3D model	Open · Scan
TFS_sp_O75475_PSIP1_HUMAN:1:91_8pc6_L_1	ModCRE	Homology model	ACCCCGCGCGG	Region 1-91 · 1 3D model	Open · Scan
TFS_sp_O75475_PSIP1_HUMAN:1:91_8peo_K_1	ModCRE	Homology model	ACCCGCGGACCGGTTGCCTGATAGCAGGGTAGGTCAGACGCTAAGAATGAGCGGGAGCGTGAAGTTCCAATCTGACCCAATAAAACCT	Region 1-91 · 1 3D model	Open · Scan
TFS_sp_O75475_PSIP1_HUMAN:1:91_8pep_L_1	ModCRE	Homology model	CCCCCGCCGCCGC	Region 1-91 · 1 3D model	Open · Scan
TFS_sp_O75475_PSIP1_HUMAN:3:91_5xsk_A_1	ModCRE	Homology model	CGCCGAA	Region 3-91 · 1 3D model	Open · Scan
TFS_sp_O75475_PSIP1_HUMAN:3:91_5xsk_B_1	ModCRE	Homology model	AAATTTCG	Region 3-91 · 1 3D model	Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 530 aa

1-91

Region 1-91 7 PWM

Residues: 91 aa
Domains: PF00855 · PWWP domain
3D models: 8 active PDBs · 5 summary rows
Templates: 5VC8, 5XSK, 8CBQ, 8PC5, 8PC6, 8PEO, 8PEP
Sources: Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

8 active PDB models 5 summary rows

Region 1-918 models · 5 summary rows

				Actions
Predicted = Low	TFS_sp_O75475_PSIP1_HUMAN:1:91_8cbq_K_1	8cbq	1-91	View model · PDB
Predicted = Low	TFS_sp_O75475_PSIP1_HUMAN:1:91_8pc5_K_1	8pc5	1-91	View model · PDB
Predicted = Low	TFS_sp_O75475_PSIP1_HUMAN:1:91_8pc6_L_1	8pc6	1-91	View model · PDB
Predicted = Low	TFS_sp_O75475_PSIP1_HUMAN:1:91_8peo_K_1	8peo	1-91	View model · PDB
Predicted = Low	TFS_sp_O75475_PSIP1_HUMAN:1:91_8pep_L_1	8pep	1-91	View model · PDB
Predicted = Low	TFS_sp_O75475_PSIP1_HUMAN:3:91_5xsk_A_1	5xsk	3-91	View model · PDB
Predicted = Low	TFS_sp_O75475_PSIP1_HUMAN:3:91_5xsk_B_1	5xsk	3-91	View model · PDB
Predicted = Low	TFS_sp_O75475_PSIP1_HUMAN:5:29_5vc8_A_1	5vc8	5-29	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
1	8pep	1:91	1	91	P:L · DNA:I,J	94.5% / 94.5%	100	View · PDB TFS_sp_O75475_PSIP1_HUMAN:1:91_8pep_L_1
2	8peo	1:91	1	91	P:K · DNA:I,J	94.5% / 94.5%	100	View · PDB TFS_sp_O75475_PSIP1_HUMAN:1:91_8peo_K_1
3	8pc6	1:91	1	91	P:L · DNA:I,J	94.5% / 94.5%	100	View · PDB TFS_sp_O75475_PSIP1_HUMAN:1:91_8pc6_L_1
4	8pc5	1:91	1	91	P:K · DNA:I,J	94.5% / 94.5%	100	View · PDB TFS_sp_O75475_PSIP1_HUMAN:1:91_8pc5_K_1
5	8cbq	1:91	1	91	P:K · DNA:I,J	94.5% / 94.5%	100	View · PDB TFS_sp_O75475_PSIP1_HUMAN:1:91_8cbq_K_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
8-87	PF00855	PWWP domain	overlaps 1-91
349-449	PF11467	Lens epithelium-derived growth factor (LEDGF)	No overlap with loaded model regions