ModCRE DB

Transcription factor

P10075 - GLI4

Zinc finger protein GLI4 (Krueppel-related zinc finger protein 4) (Protein HKR4)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 376 aa

132 Generated PWM 11 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known1
MotifPredictionSourceDNA bindingSupportLogoActions
M08394_2.00 Known CisBP TGGGCCTGGCATTCAAGGCCC Direct PWM Open · Scan
Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)126
MotifPredictionSourceDNA bindingSupportLogoActions
M00939_2.00 NN 70-40% CisBP CCACCTCA 68.2% identity Open · Scan
M00960_2.00 NN 70-40% CisBP TGCATCCC 68.2% identity Open · Scan
M00953_2.00 NN 70-40% CisBP ATCTATAT 65.8% identity Open · Scan
MA1587.1 NN 70-40% JASPAR CCTCGACCTCCTGA 65.6% identity Open · Scan
M00950_2.00 NN 70-40% CisBP GCAGCCCA 64.7% identity Open · Scan
M00955_2.00 NN 70-40% CisBP ACGTCCTCT 64.7% identity Open · Scan
M07689_2.00 NN 70-40% CisBP ACCCAGGCTCCTTCCATCTTGTGGCTC 64.1% identity Open · Scan
M00944_2.00 NN 70-40% CisBP TCGCTATAA 63.5% identity Open · Scan
M00948_2.00 NN 70-40% CisBP GCAGCACC 63.5% identity Open · Scan
M00952_2.00 NN 70-40% CisBP GGATGCTC 63.5% identity Open · Scan
M00958_2.00 NN 70-40% CisBP CGGCATCCC 63.5% identity Open · Scan
M00959_2.00 NN 70-40% CisBP GCCCTCCC 63.5% identity Open · Scan
M00782_2.00 NN 70-40% CisBP AGTGTGCGCTA 63.0% identity Open · Scan
M08355_2.00 NN 70-40% CisBP GCGAACTCCTATTCATCC 62.5% identity Open · Scan
M00943_2.00 NN 70-40% CisBP CCCGCTGC 62.3% identity Open · Scan
M08371_2.00 NN 70-40% CisBP CCAGACTTGTCCTCT 62.0% identity Open · Scan
M08944_2.00 NN 70-40% CisBP TACCATGCTGTTTTGATTAC 62.0% identity Open · Scan
MA1124.1 NN 70-40% JASPAR CATTCATTCATTC 61.4% identity Open · Scan
M07658_2.00 NN 70-40% CisBP CCGCCGCAGCCGCCG 61.1% identity Open · Scan
M08274_2.00 NN 70-40% CisBP TTACTTGCAGCCCAACGCATTCCTAAC 61.1% identity Open · Scan
M08917_2.00 NN 70-40% CisBP GCTGAGCCATGTGGGGTGCT 61.1% identity Open · Scan
M07707_2.00 NN 70-40% CisBP TCCCGC 61.0% identity Open · Scan
M08267_2.00 NN 70-40% CisBP CAGTTTCATTTTCC 61.0% identity Open · Scan
M08279_2.00 NN 70-40% CisBP CCTCCCTCC 60.6% identity Open · Scan
M07590_2.00 NN 70-40% CisBP TTTTTTTCTTTTATTTTTTTTTTTTTTTTTTTT 60.5% identity Open · Scan
M07700_2.00 NN 70-40% CisBP ATGTTGTGAGGAAGCCCA 60.5% identity Open · Scan
M04598_2.00 NN 70-40% CisBP CGCTAACTCTCCACA 60.0% identity Open · Scan
M07678_2.00 NN 70-40% CisBP CCCGCCCCCTCCTCCCCCTTCCCACCC 60.0% identity Open · Scan
M08292_2.00 NN 70-40% CisBP TGTATTCCTTGTCATGTGTGG 59.5% identity Open · Scan
M02924_2.00 NN 70-40% CisBP AGTGTTAACAGAACACCT 59.4% identity Open · Scan
M08256_2.00 NN 70-40% CisBP GTGCCTT 59.4% identity Open · Scan
M04653_2.00 NN 70-40% CisBP GGTACGGTTGTCCATGTTGCAA 59.3% identity Open · Scan
M08255_2.00 NN 70-40% CisBP CTCTTCCGGT 59.3% identity Open · Scan
M08334_2.00 NN 70-40% CisBP TTTGTTTTTTTCTGATTGCTTTTTACTTAT 59.1% identity Open · Scan
M07635_2.00 NN 70-40% CisBP AAGTTTTCTTGTATTATATCT 58.9% identity Open · Scan
M08375_2.00 NN 70-40% CisBP TTCCCCATTGGCTACTGCACCGGTCCT 58.9% identity Open · Scan
M08985_2.00 NN 70-40% CisBP TGAGGACCTACTGTGTGCC 58.7% identity Open · Scan
M04611_2.00 NN 70-40% CisBP CTTTCGGACAC 58.6% identity Open · Scan
M07733_2.00 NN 70-40% CisBP TCTTTCTCTCTCTCC 58.4% identity Open · Scan
M08314_2.00 NN 70-40% CisBP ATTCATCAAGGTCCTCAACAATGG 58.4% identity Open · Scan
M08347_2.00 NN 70-40% CisBP GCCCTGGGCAGC 58.4% identity Open · Scan
M08934_2.00 NN 70-40% CisBP GCTGTACCTGCTTATTAGGC 58.4% identity Open · Scan
M08342_2.00 NN 70-40% CisBP GCTCTGCCTCCCTCT 58.2% identity Open · Scan
M08325_2.00 NN 70-40% CisBP TTTTTTTTT 58.1% identity Open · Scan
M07605_2.00 NN 70-40% CisBP TATTTTTTTTTATTTTTTTTTTTTTTTTTT 57.9% identity Open · Scan
M07660_2.00 NN 70-40% CisBP CCGCGCCTACCTGAGGGCGCGGGCCTGGGG 57.5% identity Open · Scan
M08252_2.00 NN 70-40% CisBP CCGGCTCCAGCACCC 57.5% identity Open · Scan
M08914_2.00 NN 70-40% CisBP ATTTAGTCCATTTACATTTAATGT 57.5% identity Open · Scan
M07578_2.00 NN 70-40% CisBP CAACTCTCC 57.4% identity Open · Scan
M07714_2.00 NN 70-40% CisBP AGCCCATTGGGGCCTATGCCC 57.4% identity Open · Scan
M07753_2.00 NN 70-40% CisBP TGCATTCCTTGGCTTGTG 57.4% identity Open · Scan
M08311_2.00 NN 70-40% CisBP CTGGAACAGAAGGGGCGA 57.4% identity Open · Scan
M07581_2.00 NN 70-40% CisBP TCCCCTGTGCTTCTCTCCCCT 57.0% identity Open · Scan
M04650_2.00 NN 70-40% CisBP GCATAACTGCCCCGCTGCC 56.9% identity Open · Scan
M07610_2.00 NN 70-40% CisBP CCTTCTTCCTCCCCCCTGCCCACC 56.9% identity Open · Scan
M07648_2.00 NN 70-40% CisBP GCTTGCAAAAAAAATTTAACTCCCAGCTC 56.9% identity Open · Scan
M07649_2.00 NN 70-40% CisBP CCCCCCCCCCCCTCAGGAATGCC 56.9% identity Open · Scan
M08291_2.00 NN 70-40% CisBP AATCCAGCCCTAGACTCTCCC 56.9% identity Open · Scan
M04475_2.00 NN 70-40% CisBP GATGCACGTACCGTGCCTCA 56.6% identity Open · Scan
M08392_2.00 NN 70-40% CisBP CTTCACCTGCTGAGG 56.5% identity Open · Scan
M04465_2.00 NN 70-40% CisBP GTGATTCTTATCTTATCCTT 56.4% identity Open · Scan
M05853_2.00 NN 70-40% CisBP CCACCTTTAGCCATATCT 56.4% identity Open · Scan
M07646_2.00 NN 70-40% CisBP CTTTTTTTT 56.4% identity Open · Scan
M07684_2.00 NN 70-40% CisBP CCTGTTCTTGACTTT 56.4% identity Open · Scan
M07712_2.00 NN 70-40% CisBP ACATTTTTTTAATCTAAAAAAACATTTACA 56.4% identity Open · Scan
M08335_2.00 NN 70-40% CisBP AGTCGTTGTCTG 56.4% identity Open · Scan
M04387_2.00 NN 70-40% CisBP CGTGCTCCCC 56.3% identity Open · Scan
M04613_2.00 NN 70-40% CisBP CTCATGTGCTAATTACAAA 56.2% identity Open · Scan
M07598_2.00 NN 70-40% CisBP CTGACAATACCAAGTGTTGAC 55.9% identity Open · Scan
MA1600.1 NN 70-40% JASPAR ATACAGTCCACCCCTTTA 55.9% identity Open · Scan
M07582_2.00 NN 70-40% CisBP TCCCTG 55.8% identity Open · Scan
M08309_2.00 NN 70-40% CisBP AAAAACCCCCCTGCAGAGCCCAGCCCT 55.8% identity Open · Scan
M08395_2.00 NN 70-40% CisBP GCTGCCTACTCTTCC 55.8% identity Open · Scan
M08860_2.00 NN 70-40% CisBP TCTTATAAGGGCACTAATCCCATT 55.8% identity Open · Scan
M07683_2.00 NN 70-40% CisBP GTGGGAAAGCCT 55.7% identity Open · Scan
M08901_2.00 NN 70-40% CisBP CCAGTTCACACC 55.7% identity Open · Scan
MA1601.1 NN 70-40% JASPAR ATGTGGGAAA 55.7% identity Open · Scan
M07761_2.00 NN 70-40% CisBP CTGATTATTCACCCA 55.5% identity Open · Scan
MA1602.1 NN 70-40% JASPAR CGTCTACACGGG 55.5% identity Open · Scan
M04590_2.00 NN 70-40% CisBP TGCGCTAACCATTGC 55.3% identity Open · Scan
M07566_2.00 NN 70-40% CisBP TCAAACCATCCTTGC 55.3% identity Open · Scan
M07587_2.00 NN 70-40% CisBP CCCCCTCCCCAGTCGAGCCCCCGC 55.3% identity Open · Scan
M07686_2.00 NN 70-40% CisBP TAGCTTGTTTCCAGCCAC 55.3% identity Open · Scan
M08329_2.00 NN 70-40% CisBP GCTGCATAGTATTCC 55.3% identity Open · Scan
M08373_2.00 NN 70-40% CisBP CCCCCTGGCTCTTCCTCT 55.3% identity Open · Scan
M08386_2.00 NN 70-40% CisBP GCCTTAAAAGCTCAGCAC 55.2% identity Open · Scan
M00945_2.00 NN 70-40% CisBP CACCGCAC 55.1% identity Open · Scan
M07777_2.00 NN 70-40% CisBP GCCAATTTCCGTGGTGTAAAT 55.1% identity Open · Scan
M07746_2.00 NN 70-40% CisBP CAGCTGGCGCCCAACATGGGTCCC 55.0% identity Open · Scan
M04621_2.00 NN 70-40% CisBP AGCAATTCCGCTCA 54.8% identity Open · Scan
M07667_2.00 NN 70-40% CisBP CCGCACAGGCCCCCGGGCCCC 54.8% identity Open · Scan
M08254_2.00 NN 70-40% CisBP CTGCCCTGGGACTTT 54.8% identity Open · Scan
M08357_2.00 NN 70-40% CisBP GAGCCTGCTACTGAGCCTGGG 54.8% identity Open · Scan
MA1589.1 NN 70-40% JASPAR TAGGAGTGGAATTGCTGGGTC 54.8% identity Open · Scan
M07579_2.00 NN 70-40% CisBP CATCTCCAGGA 54.7% identity Open · Scan
M07593_2.00 NN 70-40% CisBP AGATGAAGTCACCCCTCTTAC 54.4% identity Open · Scan
M08903_2.00 NN 70-40% CisBP ATTCCATTCTATTCCATTCT 54.4% identity Open · Scan
M00609_2.00 NN 70-40% CisBP GGAAGCCCTA 54.1% identity Open · Scan
M07588_2.00 NN 70-40% CisBP TCCTTCCCTCTTTCC 53.8% identity Open · Scan
M07691_2.00 NN 70-40% CisBP CCTGCAGCCACCTTGGCCTTG 53.8% identity Open · Scan
M07717_2.00 NN 70-40% CisBP GGCTCCGCCCCC 53.8% identity Open · Scan
M08300_2.00 NN 70-40% CisBP CTGCCCAATTCAT 53.2% identity Open · Scan
M04505_2.00 NN 70-40% CisBP AGCTTTTCCCACAC 53.0% identity Open · Scan
M07562_2.00 NN 70-40% CisBP GAAAAAAAC 53.0% identity Open · Scan
M07601_2.00 NN 70-40% CisBP CAGATGCCGGCACCATGCTTC 53.0% identity Open · Scan
M07600_2.00 NN 70-40% CisBP GCATTAGC 52.8% identity Open · Scan
M07723_2.00 NN 70-40% CisBP CCGCTGCTCCCTGCT 52.8% identity Open · Scan
M07623_2.00 NN 70-40% CisBP GTCTAATAGAGCTGGGCTGCA 52.5% identity Open · Scan
M07699_2.00 NN 70-40% CisBP GGTTTAT 52.3% identity Open · Scan
M08367_2.00 NN 70-40% CisBP GGGGTGATGACCACTCTGGCTTCTTAC 52.3% identity Open · Scan
MA1656.1 NN 70-40% JASPAR CCAAGCCCAACCAG 52.2% identity Open · Scan
M07645_2.00 NN 70-40% CisBP CTCCTT 52.0% identity Open · Scan
M00786_2.00 NN 70-40% CisBP TATATATAT 51.8% identity Open · Scan
M07770_2.00 NN 70-40% CisBP CTTGGACTT 51.7% identity Open · Scan
M08283_2.00 NN 70-40% CisBP GACTTTTATTTT 51.7% identity Open · Scan
M07729_2.00 NN 70-40% CisBP CCAGACTGCCTGCCAAAACCCCCT 51.6% identity Open · Scan
M00142_2.00 NN 70-40% CisBP GTGCTCCT 51.5% identity Open · Scan
M08366_2.00 NN 70-40% CisBP GTTTGCTGCTTACAA 51.5% identity Open · Scan
M04536_2.00 NN 70-40% CisBP ACGTAACCCGATACC 51.3% identity Open · Scan
M08887_2.00 NN 70-40% CisBP CCTCCTCCAGGAAGCCTTCCCTGA 51.3% identity Open · Scan
M08399_2.00 NN 70-40% CisBP TACTCTGGGGCCACATGACTC 51.2% identity Open · Scan
M07631_2.00 NN 70-40% CisBP AATTTCAAAAATGCTATGGGC 50.5% identity Open · Scan
M08247_2.00 NN 70-40% CisBP AAAAATAACAAACGG 50.2% identity Open · Scan
MA1594.1 NN 70-40% JASPAR AGGGGACATCACTACAGATCCCAC 50.2% identity Open · Scan
MA0528.1 NN 70-40% JASPAR GGAGGAGGAGGGGGAGGAGGA 50.0% identity Open · Scan
MA0740.1 NN 70-40% JASPAR GGCCACGCCCCCTT 50.0% identity Open · Scan
ModCRE5
MotifPredictionSourceDNA bindingSupportLogoActions
TFS_sp_P10075_GLI4_HUMAN:171:207_2i13_A_1 ModCRE Homology model AGCACTGCTGGAA Region 171-207 · 1 3D model Open · Scan
TFS_sp_P10075_GLI4_HUMAN:174:207_5eh2_F_1 ModCRE Homology model CCCCCTGGGATAG Region 174-207 · 1 3D model Open · Scan
TFS_sp_P10075_GLI4_HUMAN:174:207_5v3j_E_1 ModCRE Homology model GGGGAGAGCCTCA Region 174-207 · 1 3D model Open · Scan
TFS_sp_P10075_GLI4_HUMAN:174:207_5v3m_C_1 ModCRE Homology model GGGGATTGGCACT Region 174-207 · 1 3D model Open · Scan
TFS_sp_P10075_GLI4_HUMAN:174:207_5wjq_D_1 ModCRE Homology model CTGGCTTGGCCCT Region 174-207 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 376 aa
171-373

Region 171-373 5 PWM

Residues
203 aa
Domains
PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type
3D models
11 active PDBs · 6 summary rows
Templates
1LLM, 2I13, 5EH2, 5EI9, 5V3J, 5V3M, 5WJQ
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
11 active PDB models 6 summary rows
Region 171-37311 models · 6 summary rows
Actions
Predicted = Low DIMER_sp_P10075_GLI4_HUMAN:237:286_1llm_D_1 1llm 237-286 View model · PDB
Predicted = Low TFS_sp_P10075_GLI4_HUMAN:171:207_2i13_A_1 2i13 171-207 View model · PDB
Predicted = Low TFS_sp_P10075_GLI4_HUMAN:174:207_5eh2_F_1 5eh2 174-207 View model · PDB
Predicted = Low TFS_sp_P10075_GLI4_HUMAN:174:207_5v3j_E_1 5v3j 174-207 View model · PDB
Predicted = Low TFS_sp_P10075_GLI4_HUMAN:174:207_5v3m_C_1 5v3m 174-207 View model · PDB
Predicted = Low TFS_sp_P10075_GLI4_HUMAN:174:207_5wjq_D_1 5wjq 174-207 View model · PDB
Predicted = Low TFS_sp_P10075_GLI4_HUMAN:179:373_5v3j_E_1 5v3j 179-373 View model · PDB
Predicted = Low TFS_sp_P10075_GLI4_HUMAN:179:373_5v3m_C_1 5v3m 179-373 View model · PDB
Predicted = Low TFS_sp_P10075_GLI4_HUMAN:179:373_5wjq_D_1 5wjq 179-373 View model · PDB
Predicted = Low TFS_sp_P10075_GLI4_HUMAN:228:373_2i13_A_1 2i13 228-373 View model · PDB
Predicted = Low TFS_sp_P10075_GLI4_HUMAN:236:346_5ei9_E_1 5ei9 236-346 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
5 5ei9 171:376 236 346 P:E · DNA:A,B 59.5% / 70.3% 100 View · PDB TFS_sp_P10075_GLI4_HUMAN:236:346_5ei9_E_1
4 2i13 171:376 228 373 P:A · DNA:C,D 55.5% / 68.5% 94 View · PDB TFS_sp_P10075_GLI4_HUMAN:228:373_2i13_A_1
1 5wjq 171:376 179 373 P:D · DNA:A,B 50.8% / 66.7% 69 View · PDB TFS_sp_P10075_GLI4_HUMAN:179:373_5wjq_D_1
1 1llm 171:376 237,237 286,286 P:C,D · DNA:A,B 48.0% / 64.0% 57,58 View · PDB DIMER_sp_P10075_GLI4_HUMAN:237:286_1llm_D_1
2 5v3m 171:376 179 373 P:C · DNA:A,B 47.2% / 67.2% 70 View · PDB TFS_sp_P10075_GLI4_HUMAN:179:373_5v3m_C_1
3 5v3j 171:376 179 373 P:E · DNA:A,B 47.2% / 67.2% 70 View · PDB TFS_sp_P10075_GLI4_HUMAN:179:373_5v3j_E_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
183-205PF00096Zinc finger, C2H2 typeoverlaps 171-373
211-233PF00096Zinc finger, C2H2 typeoverlaps 171-373
239-261PF00096Zinc finger, C2H2 typeoverlaps 171-373
267-289PF00096Zinc finger, C2H2 typeoverlaps 171-373
295-317PF00096Zinc finger, C2H2 typeoverlaps 171-373
323-345PF00096Zinc finger, C2H2 typeoverlaps 171-373
351-373PF00096Zinc finger, C2H2 typeoverlaps 171-373