ModCRE DB

Transcription factor

P12980 - LYL1

Protein lyl-1 (Class A basic helix-loop-helix protein 18) (bHLHa18) (Lymphoblastic leukemia-derived sequence 1)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 280 aa

28 Generated PWM 13 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known2
MotifPredictionSourceDNA bindingSupportLogoActions
M08714_2.00 Known CisBP CAGGAAACAGCTGG Direct PWM Open · Scan
LYL1_HUMAN.H11MO.0.A Known HOCOMOCO CCAGCTGTTTCCTG Direct PWM Open · Scan
Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)13
MotifPredictionSourceDNA bindingSupportLogoActions
MA0140.1 NN 70-40% JASPAR CTGGTGGGGACAGATAAG 65.3% identity Open · Scan
M00756_2.00 NN 70-40% CisBP CGCAGCTGTG 64.0% identity Open · Scan
MA0048.1 NN 70-40% JASPAR GCGCAGCTGCGT 64.0% identity Open · Scan
MA1529.1 NN 70-40% JASPAR GGGCCGCAGCTGCGTCCC 64.0% identity Open · Scan
MA0091.1 NN 70-40% JASPAR CGACCATCTGTT 58.0% identity Open · Scan
M06000_2.00 NN 70-40% CisBP CCAGATGGCACGGACACAACA 57.4% identity Open · Scan
M05965_2.00 NN 70-40% CisBP AAAAACACCTGCGCC 55.9% identity Open · Scan
MA1123.1 NN 70-40% JASPAR ATTCCAGATGTTT 54.3% identity Open · Scan
M05962_2.00 NN 70-40% CisBP CCACCTGCC 52.6% identity Open · Scan
MA1638.1 NN 70-40% JASPAR ACCAGATGGC 52.4% identity Open · Scan
M01718_2.00 NN 70-40% CisBP AACATATGGT 50.8% identity Open · Scan
M05952_2.00 NN 70-40% CisBP ACCATCTGCCG 50.8% identity Open · Scan
MA0633.1 NN 70-40% JASPAR ACCATATGTT 50.8% identity Open · Scan
ModCRE13
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_sp_P12980_LYL1_HUMAN:148:209_2ypa_A_1 ModCRE Homology model AACACGTGTGT Region 148-209 · 1 3D model Open · Scan
DIMER_sp_P12980_LYL1_HUMAN:148:209_2ypb_A_1 ModCRE Homology model AACCCATAGCC Region 148-209 · 1 3D model Open · Scan
DIMER_sp_P12980_LYL1_HUMAN:150:199_4h10_B_1 ModCRE Homology model GGCAACATTTGCCA Region 150-199 · 1 3D model Open · Scan
DIMER_sp_P12980_LYL1_HUMAN:150:207_2ql2_B_1 ModCRE Homology model GGCAACCTATGTTAGC Region 150-207 · 1 3D model Open · Scan
DIMER_sp_P12980_LYL1_HUMAN:151:199_7z5i_B_1 ModCRE Homology model TCTCAACAGGGGGGCCGG Region 151-199 · 1 3D model Open · Scan
DIMER_sp_P12980_LYL1_HUMAN:151:205_7z5k_B_1 ModCRE Homology model GGGCAACAGCTGGCTAGG Region 151-205 · 1 3D model Open · Scan
DIMER_sp_P12980_LYL1_HUMAN:151:208_1mdy_A_1 ModCRE Homology model GGGCCAGCTGGGCA Region 151-208 · 1 3D model Open · Scan
TFS_sp_P12980_LYL1_HUMAN:148:209_2ypa_A_1 ModCRE Homology model ACAAACGTGGT Region 148-209 · 1 3D model Open · Scan
TFS_sp_P12980_LYL1_HUMAN:148:209_2ypb_A_1 ModCRE Homology model GCAGCTGGGGT Region 148-209 · 1 3D model Open · Scan
TFS_sp_P12980_LYL1_HUMAN:150:207_2ql2_B_1 ModCRE Homology model GGGCACCGCTTTTGCA Region 150-207 · 1 3D model Open · Scan
TFS_sp_P12980_LYL1_HUMAN:151:205_7z5k_B_1 ModCRE Homology model CCGAGCCAGCTGTTGCAA Region 151-205 · 1 3D model Open · Scan
TFS_sp_P12980_LYL1_HUMAN:151:208_1mdy_A_1 ModCRE Homology model TGCCCAGCTGGCCA Region 151-208 · 1 3D model Open · Scan
TFS_sp_P12980_LYL1_HUMAN:151:208_6od5_B_1 ModCRE Homology model GCAGTATGCTAT Region 151-208 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 280 aa
148-209

Region 148-209 13 PWM

Residues
62 aa
Domains
PF00010 · Helix-loop-helix DNA-binding domain
3D models
13 active PDBs · 10 summary rows
Templates
1MDY, 2QL2, 2YPA, 2YPB, 4H10, 6OD5, 7Z5I, 7Z5K
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
13 active PDB models 10 summary rows
Region 148-20913 models · 10 summary rows
Actions
Predicted = Low DIMER_sp_P12980_LYL1_HUMAN:148:209_2ypa_A_1 2ypa 148-209 View model · PDB
Predicted = Low DIMER_sp_P12980_LYL1_HUMAN:148:209_2ypb_A_1 2ypb 148-209 View model · PDB
Predicted = Low DIMER_sp_P12980_LYL1_HUMAN:150:199_4h10_B_1 4h10 150-199 View model · PDB
Predicted = Low DIMER_sp_P12980_LYL1_HUMAN:150:207_2ql2_B_1 2ql2 150-207 View model · PDB
Predicted = Low DIMER_sp_P12980_LYL1_HUMAN:151:199_7z5i_B_1 7z5i 151-199 View model · PDB
Predicted = Low DIMER_sp_P12980_LYL1_HUMAN:151:205_7z5k_B_1 7z5k 151-205 View model · PDB
Predicted = Low DIMER_sp_P12980_LYL1_HUMAN:151:208_1mdy_A_1 1mdy 151-208 View model · PDB
Predicted = Low TFS_sp_P12980_LYL1_HUMAN:148:209_2ypa_A_1 2ypa 148-209 View model · PDB
Predicted = Low TFS_sp_P12980_LYL1_HUMAN:148:209_2ypb_A_1 2ypb 148-209 View model · PDB
Predicted = Low TFS_sp_P12980_LYL1_HUMAN:150:207_2ql2_B_1 2ql2 150-207 View model · PDB
Predicted = Low TFS_sp_P12980_LYL1_HUMAN:151:205_7z5k_B_1 7z5k 151-205 View model · PDB
Predicted = Low TFS_sp_P12980_LYL1_HUMAN:151:208_1mdy_A_1 1mdy 151-208 View model · PDB
Predicted = Low TFS_sp_P12980_LYL1_HUMAN:151:208_6od5_B_1 6od5 151-208 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
1 2ypa 121:209 148,151 209,209 P:A,B · DNA:E,F 85.5% / 93.5% 92,80 View · PDB DIMER_sp_P12980_LYL1_HUMAN:148:209_2ypa_A_1
1 2ypa 121:209 148,151 209,209 P:A,B · DNA:E,F 85.5% / 93.5% 92,80 View · PDB TFS_sp_P12980_LYL1_HUMAN:148:209_2ypa_A_1
2 2ypb 121:209 148,151 209,209 P:A,B · DNA:E,F 85.5% / 93.5% 92,79 View · PDB DIMER_sp_P12980_LYL1_HUMAN:148:209_2ypb_A_1
2 2ypb 121:209 148,151 209,209 P:A,B · DNA:E,F 85.5% / 93.5% 92,79 View · PDB TFS_sp_P12980_LYL1_HUMAN:148:209_2ypb_A_1
3 2ql2 121:209 150 207 P:B · DNA:E,F 46.6% / 62.1% 98 View · PDB TFS_sp_P12980_LYL1_HUMAN:150:207_2ql2_B_1
3 1mdy 121:209 151,151 208,208 P:A,B · DNA:E,F 43.1% / 60.3% 83,91 View · PDB DIMER_sp_P12980_LYL1_HUMAN:151:208_1mdy_A_1
4 1mdy 121:209 151,151 208,208 P:A,B · DNA:E,F 43.1% / 60.3% 83,91 View · PDB TFS_sp_P12980_LYL1_HUMAN:151:208_1mdy_A_1
5 7z5i 121:209 151,151 199,199 P:A,B · DNA:E,F 42.9% / 63.3% 85,85 View · PDB DIMER_sp_P12980_LYL1_HUMAN:151:199_7z5i_B_1
4 7z5k 121:209 151,151 199,205 P:A,B · DNA:E,F 41.8% / 60.0% 85,96 View · PDB DIMER_sp_P12980_LYL1_HUMAN:151:205_7z5k_B_1
5 7z5k 121:209 151,151 199,205 P:A,B · DNA:E,F 41.8% / 60.0% 85,96 View · PDB TFS_sp_P12980_LYL1_HUMAN:151:205_7z5k_B_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
151-202PF00010Helix-loop-helix DNA-binding domainoverlaps 148-209