Transcription factor

P17030 - ZNF25

Zinc finger protein 25 (Zinc finger protein KOX19)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 456 aa

83 Generated PWM 11 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known1

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
M07643_2.00	Known	CisBP	TTTCTAAATGCAGCAACCTCTGTTCTTCA	Direct PWM		Open · Scan

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)76

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
M00953_2.00	NN 70-40%	CisBP	ATCTATAT	69.0% identity		Open · Scan
M00950_2.00	NN 70-40%	CisBP	GCAGCCCA	67.0% identity		Open · Scan
M00955_2.00	NN 70-40%	CisBP	ACGTCCTCT	67.0% identity		Open · Scan
M00944_2.00	NN 70-40%	CisBP	TCGCTATAA	65.8% identity		Open · Scan
M00959_2.00	NN 70-40%	CisBP	GCCCTCCC	65.8% identity		Open · Scan
M00948_2.00	NN 70-40%	CisBP	GCAGCACC	64.7% identity		Open · Scan
M00960_2.00	NN 70-40%	CisBP	TGCATCCC	64.7% identity		Open · Scan
M00939_2.00	NN 70-40%	CisBP	CCACCTCA	63.5% identity		Open · Scan
M00943_2.00	NN 70-40%	CisBP	CCCGCTGC	63.5% identity		Open · Scan
M00952_2.00	NN 70-40%	CisBP	GGATGCTC	63.5% identity		Open · Scan
M00958_2.00	NN 70-40%	CisBP	CGGCATCCC	63.5% identity		Open · Scan
M08263_2.00	NN 70-40%	CisBP	ATCTCGGCACTTTGGGAGGCCA	62.8% identity		Open · Scan
M04387_2.00	NN 70-40%	CisBP	CGTGCTCCCC	60.3% identity		Open · Scan
M02924_2.00	NN 70-40%	CisBP	AGTGTTAACAGAACACCT	59.2% identity		Open · Scan
M04650_2.00	NN 70-40%	CisBP	GCATAACTGCCCCGCTGCC	58.9% identity		Open · Scan
M04598_2.00	NN 70-40%	CisBP	CGCTAACTCTCCACA	58.2% identity		Open · Scan
M07648_2.00	NN 70-40%	CisBP	GCTTGCAAAAAAAATTTAACTCCCAGCTC	58.2% identity		Open · Scan
MA1124.1	NN 70-40%	JASPAR	CATTCATTCATTC	58.1% identity		Open · Scan
M04613_2.00	NN 70-40%	CisBP	CTCATGTGCTAATTACAAA	57.9% identity		Open · Scan
M07712_2.00	NN 70-40%	CisBP	ACATTTTTTTAATCTAAAAAAACATTTACA	57.6% identity		Open · Scan
M08325_2.00	NN 70-40%	CisBP	TTTTTTTTT	57.4% identity		Open · Scan
M07578_2.00	NN 70-40%	CisBP	CAACTCTCC	57.1% identity		Open · Scan
M08329_2.00	NN 70-40%	CisBP	GCTGCATAGTATTCC	56.9% identity		Open · Scan
M08267_2.00	NN 70-40%	CisBP	CAGTTTCATTTTCC	56.8% identity		Open · Scan
M07590_2.00	NN 70-40%	CisBP	TTTTTTTCTTTTATTTTTTTTTTTTTTTTTTTT	56.2% identity		Open · Scan
M07579_2.00	NN 70-40%	CisBP	CATCTCCAGGA	56.0% identity		Open · Scan
M08375_2.00	NN 70-40%	CisBP	TTCCCCATTGGCTACTGCACCGGTCCT	56.0% identity		Open · Scan
M07581_2.00	NN 70-40%	CisBP	TCCCCTGTGCTTCTCTCCCCT	55.8% identity		Open · Scan
M08254_2.00	NN 70-40%	CisBP	CTGCCCTGGGACTTT	55.7% identity		Open · Scan
M08292_2.00	NN 70-40%	CisBP	TGTATTCCTTGTCATGTGTGG	55.3% identity		Open · Scan
M00782_2.00	NN 70-40%	CisBP	AGTGTGCGCTA	55.1% identity		Open · Scan
M07678_2.00	NN 70-40%	CisBP	CCCGCCCCCTCCTCCCCCTTCCCACCC	55.1% identity		Open · Scan
M08355_2.00	NN 70-40%	CisBP	GCGAACTCCTATTCATCC	55.1% identity		Open · Scan
M08373_2.00	NN 70-40%	CisBP	CCCCCTGGCTCTTCCTCT	55.0% identity		Open · Scan
M08901_2.00	NN 70-40%	CisBP	CCAGTTCACACC	55.0% identity		Open · Scan
M07610_2.00	NN 70-40%	CisBP	CCTTCTTCCTCCCCCCTGCCCACC	54.8% identity		Open · Scan
MA1656.1	NN 70-40%	JASPAR	CCAAGCCCAACCAG	54.7% identity		Open · Scan
M07649_2.00	NN 70-40%	CisBP	CCCCCCCCCCCCTCAGGAATGCC	54.6% identity		Open · Scan
M04611_2.00	NN 70-40%	CisBP	CTTTCGGACAC	54.5% identity		Open · Scan
M07662_2.00	NN 70-40%	CisBP	CCTGTGTCCTCCCTGGTCCCC	54.4% identity		Open · Scan
M08949_2.00	NN 70-40%	CisBP	TTCTATTTCTTCTTGTGTCA	54.4% identity		Open · Scan
M00134_2.00	NN 70-40%	CisBP	GCCACGCCCA	54.2% identity		Open · Scan
M00945_2.00	NN 70-40%	CisBP	CACCGCAC	54.0% identity		Open · Scan
M08395_2.00	NN 70-40%	CisBP	GCTGCCTACTCTTCC	54.0% identity		Open · Scan
M04536_2.00	NN 70-40%	CisBP	ACGTAACCCGATACC	53.6% identity		Open · Scan
M04465_2.00	NN 70-40%	CisBP	GTGATTCTTATCTTATCCTT	53.5% identity		Open · Scan
M07588_2.00	NN 70-40%	CisBP	TCCTTCCCTCTTTCC	53.4% identity		Open · Scan
MA1602.1	NN 70-40%	JASPAR	CGTCTACACGGG	53.4% identity		Open · Scan
M03671_2.00	NN 70-40%	CisBP	ATTACCATACAAGTGCAC	53.3% identity		Open · Scan
MA1601.1	NN 70-40%	JASPAR	ATGTGGGAAA	53.3% identity		Open · Scan
MA1154.1	NN 70-40%	JASPAR	CTTTCCCACAACACGAC	53.2% identity		Open · Scan
M00786_2.00	NN 70-40%	CisBP	TATATATAT	53.1% identity		Open · Scan
M07605_2.00	NN 70-40%	CisBP	TATTTTTTTTTATTTTTTTTTTTTTTTTTT	53.1% identity		Open · Scan
M07747_2.00	NN 70-40%	CisBP	TGGTCTATAAAGGGCCTGGTT	53.0% identity		Open · Scan
M01474_2.00	NN 70-40%	CisBP	CGCCGATCAC	52.9% identity		Open · Scan
MA0528.1	NN 70-40%	JASPAR	GGAGGAGGAGGGGGAGGAGGA	52.9% identity		Open · Scan
M07777_2.00	NN 70-40%	CisBP	GCCAATTTCCGTGGTGTAAAT	52.8% identity		Open · Scan
M08334_2.00	NN 70-40%	CisBP	TTTGTTTTTTTCTGATTGCTTTTTACTTAT	52.8% identity		Open · Scan
M08314_2.00	NN 70-40%	CisBP	ATTCATCAAGGTCCTCAACAATGG	52.6% identity		Open · Scan
M04621_2.00	NN 70-40%	CisBP	AGCAATTCCGCTCA	52.5% identity		Open · Scan
M07587_2.00	NN 70-40%	CisBP	CCCCCTCCCCAGTCGAGCCCCCGC	52.2% identity		Open · Scan
M00142_2.00	NN 70-40%	CisBP	GTGCTCCT	51.7% identity		Open · Scan
M07660_2.00	NN 70-40%	CisBP	CCGCGCCTACCTGAGGGCGCGGGCCTGGGG	51.4% identity		Open · Scan
M00609_2.00	NN 70-40%	CisBP	GGAAGCCCTA	51.3% identity		Open · Scan
M07693_2.00	NN 70-40%	CisBP	CTCCTGTGTGTGCCTTGGCTG	51.2% identity		Open · Scan
M08335_2.00	NN 70-40%	CisBP	AGTCGTTGTCTG	51.2% identity		Open · Scan
M01538_2.00	NN 70-40%	CisBP	GCCCCTGA	51.1% identity		Open · Scan
M01456_2.00	NN 70-40%	CisBP	GTGATCGGCG	50.9% identity		Open · Scan
M07562_2.00	NN 70-40%	CisBP	GAAAAAAAC	50.9% identity		Open · Scan
M08234_2.00	NN 70-40%	CisBP	GTCAACTTGACTGGGCCA	50.4% identity		Open · Scan
MA1155.1	NN 70-40%	JASPAR	TGCACACACTGAAAA	50.4% identity		Open · Scan
M08887_2.00	NN 70-40%	CisBP	CCTCCTCCAGGAAGCCTTCCCTGA	50.1% identity		Open · Scan
M00217_2.00	NN 70-40%	CisBP	TTACTCAATAT	50.0% identity		Open · Scan
M00645_2.00	NN 70-40%	CisBP	CGCCCACGCA	50.0% identity		Open · Scan
M05855_2.00	NN 70-40%	CisBP	GTATTATACCCAGCT	50.0% identity		Open · Scan
M08540_2.00	NN 70-40%	CisBP	CCCCT	50.0% identity		Open · Scan

ModCRE6

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
DIMER_sp_P17030_ZNF25_HUMAN:256:305_1llm_D_1	ModCRE	Homology model	CCCGGGCGCGGA	Region 256-305 · 1 3D model		Open · Scan
TFS_sp_P17030_ZNF25_HUMAN:100:140_2i13_A_1	ModCRE	Homology model	AATAGTAGGACCG	Region 100-140 · 1 3D model		Open · Scan
TFS_sp_P17030_ZNF25_HUMAN:93:141_5egb_A_1	ModCRE	Homology model	GGGGGGGGCCCG	Region 93-141 · 1 3D model		Open · Scan
TFS_sp_P17030_ZNF25_HUMAN:93:141_5eh2_F_1	ModCRE	Homology model	GGGGGGGGGGCCAC	Region 93-141 · 1 3D model		Open · Scan
TFS_sp_P17030_ZNF25_HUMAN:93:141_5ei9_E_1	ModCRE	Homology model	GGGGGGGGGGCC	Region 93-141 · 1 3D model		Open · Scan
TFS_sp_P17030_ZNF25_HUMAN:93:141_5wjq_D_1	ModCRE	Homology model	TTGGGGGGGCTGC	Region 93-141 · 1 3D model		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 456 aa

93-141

144-449

Region 93-141 5 PWM

Residues

49 aa

Domains

PF00096 · Zinc finger, C2H2 type

3D models

5 active PDBs

Templates

2I13, 5EGB, 5EH2, 5EI9, 5WJQ

Sources

Predicted = Low

Scan this region Show models

Region 144-449 1 PWM

Residues

306 aa

Domains

PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type

3D models

6 active PDBs · 6 summary rows

Templates

1LLM, 2I13, 5V3J, 5V3M, 5WJQ, 7W1M

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

11 active PDB models 6 summary rows

Region 93-1415 models

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	TFS_sp_P17030_ZNF25_HUMAN:100:140_2i13_A_1	2i13	100-140	View model · PDB
Predicted = Low	TFS_sp_P17030_ZNF25_HUMAN:93:141_5egb_A_1	5egb	93-141	View model · PDB
Predicted = Low	TFS_sp_P17030_ZNF25_HUMAN:93:141_5eh2_F_1	5eh2	93-141	View model · PDB
Predicted = Low	TFS_sp_P17030_ZNF25_HUMAN:93:141_5ei9_E_1	5ei9	93-141	View model · PDB
Predicted = Low	TFS_sp_P17030_ZNF25_HUMAN:93:141_5wjq_D_1	5wjq	93-141	View model · PDB

Region 144-4496 models · 6 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_sp_P17030_ZNF25_HUMAN:256:305_1llm_D_1	1llm	256-305	View model · PDB
Predicted = Low	TFS_sp_P17030_ZNF25_HUMAN:144:421_5wjq_D_1	5wjq	144-421	View model · PDB
Predicted = Low	TFS_sp_P17030_ZNF25_HUMAN:173:448_7w1m_H_1	7w1m	173-448	View model · PDB
Predicted = Low	TFS_sp_P17030_ZNF25_HUMAN:174:449_5v3j_E_1	5v3j	174-449	View model · PDB
Predicted = Low	TFS_sp_P17030_ZNF25_HUMAN:174:449_5v3m_C_1	5v3m	174-449	View model · PDB
Predicted = Low	TFS_sp_P17030_ZNF25_HUMAN:183:336_2i13_A_1	2i13	183-336	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
4	2i13	144:449	183	336	P:A · DNA:C,D	63.6% / 73.4%	100	View · PDB TFS_sp_P17030_ZNF25_HUMAN:183:336_2i13_A_1
1	5wjq	144:449	144	421	P:D · DNA:A,B	53.2% / 67.6%	98	View · PDB TFS_sp_P17030_ZNF25_HUMAN:144:421_5wjq_D_1
2	5v3m	144:449	174	449	P:C · DNA:A,B	52.5% / 69.9%	99	View · PDB TFS_sp_P17030_ZNF25_HUMAN:174:449_5v3m_C_1
3	5v3j	144:449	174	449	P:E · DNA:A,B	52.5% / 69.9%	99	View · PDB TFS_sp_P17030_ZNF25_HUMAN:174:449_5v3j_E_1
1	1llm	144:449	256,256	305,305	P:C,D · DNA:A,B	48.0% / 68.0%	57,58	View · PDB DIMER_sp_P17030_ZNF25_HUMAN:256:305_1llm_D_1
5	7w1m	144:449	173	448	P:H · DNA:F,G	37.0% / 52.0%	85	View · PDB TFS_sp_P17030_ZNF25_HUMAN:173:448_7w1m_H_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
7-48	PF01352	KRAB box	No overlap with loaded model regions
119-140	PF00096	Zinc finger, C2H2 type	overlaps 93-141
146-168	PF00096	Zinc finger, C2H2 type	overlaps 144-449
174-196	PF00096	Zinc finger, C2H2 type	overlaps 144-449
202-224	PF00096	Zinc finger, C2H2 type	overlaps 144-449
230-252	PF00096	Zinc finger, C2H2 type	overlaps 144-449
258-280	PF00096	Zinc finger, C2H2 type	overlaps 144-449
286-308	PF00096	Zinc finger, C2H2 type	overlaps 144-449
314-336	PF00096	Zinc finger, C2H2 type	overlaps 144-449
342-364	PF00096	Zinc finger, C2H2 type	overlaps 144-449
370-392	PF00096	Zinc finger, C2H2 type	overlaps 144-449
398-420	PF00096	Zinc finger, C2H2 type	overlaps 144-449
426-448	PF00096	Zinc finger, C2H2 type	overlaps 144-449