Transcription factor

P81133 - SIM1

Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 766 aa

6 Generated PWM 13 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)0

No generated PWM in this category.

ModCRE6

Motif	Prediction	Source	DNA binding	Support	Actions
TFS_sp_P81133_SIM1_HUMAN:2:141_4zpk_A_1	ModCRE	Homology model	GTGCACACGACGCGT	Region 2-141 · 1 3D model	Open · Scan
TFS_sp_P81133_SIM1_HUMAN:2:141_5sy7_A_1	ModCRE	Homology model	GCGCGCGCGACGTGCACA	Region 2-141 · 1 3D model	Open · Scan
TFS_sp_P81133_SIM1_HUMAN:2:141_5v0l_A_1	ModCRE	Homology model	TTGCAAAACGT	Region 2-141 · 1 3D model	Open · Scan
TFS_sp_P81133_SIM1_HUMAN:2:333_4zpr_B_1	ModCRE	Homology model	GTGCCAACGTGCGCGGC	Region 2-333 · 1 3D model	Open · Scan
TFS_sp_P81133_SIM1_HUMAN:2:346_4zpk_B_1	ModCRE	Homology model	ACGCGCACGACGCGG	Region 2-346 · 1 3D model	Open · Scan
TFS_sp_P81133_SIM1_HUMAN:2:347_5sy7_B_1	ModCRE	Homology model	GCGCACACGACGCGGCCC	Region 2-347 · 1 3D model	Open · Scan

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 766 aa

2-347

Residues: 346 aa
Domains: PF23171 · Hypoxia-inducible factor 1-alpha bHLH domain PF00989 · PAS fold PF08447 · PAS fold
3D models: 13 active PDBs · 10 summary rows
Templates: 4ZPK, 4ZPR, 5SY7, 5V0L, 8OSK, 8OSL
Sources: Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

13 active PDB models 10 summary rows

Region 2-34713 models · 10 summary rows

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
2	4zpr	2:347	2,2	141,333	P:A,B · DNA:C,D	39.1% / 57.6%	48,96	View · PDB DIMER_sp_P81133_SIM1_HUMAN:2:333_4zpr_B_1
2	4zpr	2:347	2,2	141,333	P:A,B · DNA:C,D	39.1% / 57.6%	48,96	View · PDB TFS_sp_P81133_SIM1_HUMAN:2:333_4zpr_B_1
1	5sy7	2:347	2,2	141,347	P:A,B · DNA:C,D	38.1% / 52.5%	44,98	View · PDB DIMER_sp_P81133_SIM1_HUMAN:2:347_5sy7_B_1
1	5sy7	2:347	2,2	141,347	P:A,B · DNA:C,D	38.1% / 52.5%	44,98	View · PDB TFS_sp_P81133_SIM1_HUMAN:2:141_5sy7_A_1
3	4zpk	2:347	2,2	141,346	P:A,B · DNA:C,D	36.6% / 55.4%	45,95	View · PDB DIMER_sp_P81133_SIM1_HUMAN:2:346_4zpk_B_1
3	4zpk	2:347	2,2	141,346	P:A,B · DNA:C,D	36.6% / 55.4%	45,95	View · PDB TFS_sp_P81133_SIM1_HUMAN:2:141_4zpk_A_1
4	8osk	2:347	2,2	338,332	P:M,N · DNA:I,J	26.3% / 42.2%	96,93	View · PDB DIMER_sp_P81133_SIM1_HUMAN:2:332_8osk_N_1
4	8osk	2:347	2,2	338,332	P:M,N · DNA:I,J	26.3% / 42.2%	96,93	View · PDB TFS_sp_P81133_SIM1_HUMAN:2:332_8osk_N_1
5	8osl	2:347	2,2	332,50	P:N,P · DNA:I,J	26.3% / 42.2%	92,98	View · PDB DIMER_sp_P81133_SIM1_HUMAN:2:332_8osl_N_1
5	8osl	2:347	2,2	332,50	P:N,P · DNA:I,J	26.3% / 42.2%	92,98	View · PDB TFS_sp_P81133_SIM1_HUMAN:2:332_8osl_N_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
2-55	PF23171	Hypoxia-inducible factor 1-alpha bHLH domain	overlaps 2-347
81-142	PF00989	PAS fold	overlaps 2-347
243-329	PF08447	PAS fold	overlaps 2-347
359-669	PF06621	Single-minded protein C-terminus	No overlap with loaded model regions