ModCRE DB

Transcription factor

Q03014 - HHEX

Hematopoietically-expressed homeobox protein HHEX (Homeobox protein HEX) (Homeobox protein PRH) (Proline-rich homeodomain protein)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 270 aa

114 Generated PWM 15 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)106
MotifPredictionSourceDNA bindingSupportLogoActions
M06359_2.00 NN 70-40% CisBP TTTAATTA 67.7% identity Open · Scan
MA0124.2 NN 70-40% JASPAR ACCACTTAA 66.6% identity Open · Scan
M06361_2.00 NN 70-40% CisBP TTTAATTA 60.7% identity Open · Scan
M10805_2.00 NN 70-40% CisBP GGACAAATAGCCC 60.7% identity Open · Scan
MA0889.1 NN 70-40% JASPAR ACTAATTAGC 60.3% identity Open · Scan
M00451_2.00 NN 70-40% CisBP ATTAATTA 60.0% identity Open · Scan
M06232_2.00 NN 70-40% CisBP TTAATGA 58.9% identity Open · Scan
M03234_2.00 NN 70-40% CisBP TTTTAATTGGT 58.8% identity Open · Scan
MA0724.1 NN 70-40% JASPAR ACCGATTAG 58.8% identity Open · Scan
MA0897.1 NN 70-40% JASPAR ACAAGCAATTAAAGAAT 58.8% identity Open · Scan
M06312_2.00 NN 70-40% CisBP TTAATTA 58.4% identity Open · Scan
M06544_2.00 NN 70-40% CisBP GTAATTA 58.4% identity Open · Scan
M03775_2.00 NN 70-40% CisBP GTTTTATGTGTTTT 58.3% identity Open · Scan
MA0124.1 NN 70-40% JASPAR ATACTTA 57.8% identity Open · Scan
M00462_2.00 NN 70-40% CisBP CTAATTG 57.6% identity Open · Scan
M02107_2.00 NN 70-40% CisBP TTAATTGCT 57.6% identity Open · Scan
M09181_2.00 NN 70-40% CisBP TTTAATTGTTTT 57.6% identity Open · Scan
M09573_2.00 NN 70-40% CisBP GTTAATGA 57.6% identity Open · Scan
MA0674.1 NN 70-40% JASPAR GTAATTAA 57.6% identity Open · Scan
MA0875.1 NN 70-40% JASPAR GCAATTAG 57.6% identity Open · Scan
MA0890.1 NN 70-40% JASPAR ACCAATTAGC 57.6% identity Open · Scan
M05392_2.00 NN 70-40% CisBP GTTAAGTGC 56.8% identity Open · Scan
MA0635.1 NN 70-40% JASPAR GCTAAACGGT 56.8% identity Open · Scan
M00496_2.00 NN 70-40% CisBP TTAAGTGGTT 56.0% identity Open · Scan
M02153_2.00 NN 70-40% CisBP GCCCAATAAA 56.0% identity Open · Scan
MA0673.1 NN 70-40% JASPAR CCACTTGAA 55.9% identity Open · Scan
MA0675.1 NN 70-40% JASPAR CTAATTAA 55.9% identity Open · Scan
M00457_2.00 NN 70-40% CisBP TTAATTGCT 55.7% identity Open · Scan
MA1471.1 NN 70-40% JASPAR AAAAACCATTAC 55.7% identity Open · Scan
M02106_2.00 NN 70-40% CisBP ATATTAATTGGTT 55.5% identity Open · Scan
M06339_2.00 NN 70-40% CisBP TTTAATTGG 55.5% identity Open · Scan
MA0158.1 NN 70-40% JASPAR CACTAATT 55.3% identity Open · Scan
MA0904.1 NN 70-40% JASPAR ACGGTAATTAGCTCAT 55.3% identity Open · Scan
MA0904.2 NN 70-40% JASPAR GTAATTAC 55.3% identity Open · Scan
M01244_2.00 NN 70-40% CisBP ATTAATTAC 54.9% identity Open · Scan
M03798_2.00 NN 70-40% CisBP GGTAATTAGC 54.9% identity Open · Scan
M06539_2.00 NN 70-40% CisBP CTAATTA 54.9% identity Open · Scan
M06545_2.00 NN 70-40% CisBP TTAATTA 54.9% identity Open · Scan
M06554_2.00 NN 70-40% CisBP TTAATTG 54.9% identity Open · Scan
M02165_2.00 NN 70-40% CisBP CTTAATTGG 54.7% identity Open · Scan
M06248_2.00 NN 70-40% CisBP TAATTGCC 54.5% identity Open · Scan
M00520_2.00 NN 70-40% CisBP CTTAAGTGCT 54.2% identity Open · Scan
M02148_2.00 NN 70-40% CisBP CTAATTAG 54.2% identity Open · Scan
M03815_2.00 NN 70-40% CisBP TTAATTAG 54.2% identity Open · Scan
MA0618.1 NN 70-40% JASPAR TTAATTAG 54.2% identity Open · Scan
M02150_2.00 NN 70-40% CisBP TTAATTAA 54.1% identity Open · Scan
M06281_2.00 NN 70-40% CisBP TTAATTA 54.1% identity Open · Scan
MA1530.1 NN 70-40% JASPAR CTCATTAAA 54.0% identity Open · Scan
M02143_2.00 NN 70-40% CisBP TTAATTGG 53.8% identity Open · Scan
M00403_2.00 NN 70-40% CisBP CTAATTACC 53.7% identity Open · Scan
MA0902.1 NN 70-40% JASPAR AGTAATTAAC 53.7% identity Open · Scan
M02210_2.00 NN 70-40% CisBP AAGTACTTAA 53.4% identity Open · Scan
M00422_2.00 NN 70-40% CisBP TTAATGA 53.1% identity Open · Scan
M03799_2.00 NN 70-40% CisBP GTAATTAC 53.1% identity Open · Scan
M06548_2.00 NN 70-40% CisBP TTAATTG 52.9% identity Open · Scan
MA0132.1 NN 70-40% JASPAR CTAATT 52.9% identity Open · Scan
MA0132.2 NN 70-40% JASPAR GTAATTAG 52.9% identity Open · Scan
M02211_2.00 NN 70-40% CisBP TTAATTAC 52.8% identity Open · Scan
MA0661.1 NN 70-40% JASPAR GCTAATTAAC 52.8% identity Open · Scan
MA0886.1 NN 70-40% JASPAR GCTAATTAGC 52.7% identity Open · Scan
M03810_2.00 NN 70-40% CisBP GCTAAACGGT 52.5% identity Open · Scan
MA0699.1 NN 70-40% JASPAR GCCAATTAGC 52.5% identity Open · Scan
MA0896.1 NN 70-40% JASPAR ACAAGCAATTAATGAAT 52.5% identity Open · Scan
M00497_2.00 NN 70-40% CisBP TTAAGTGGT 52.4% identity Open · Scan
M05042_2.00 NN 70-40% CisBP GTCAAGTGGT 52.4% identity Open · Scan
M06504_2.00 NN 70-40% CisBP TTAAGTG 52.4% identity Open · Scan
MA0672.1 NN 70-40% JASPAR ACCACTTGAA 52.4% identity Open · Scan
M02170_2.00 NN 70-40% CisBP TTAATTAG 52.3% identity Open · Scan
M06290_2.00 NN 70-40% CisBP TTTAATTA 52.2% identity Open · Scan
MA0119.1 NN 70-40% JASPAR TGGCACCATGCCAA 52.2% identity Open · Scan
M00469_2.00 NN 70-40% CisBP TTAATTACC 52.0% identity Open · Scan
M05272_2.00 NN 70-40% CisBP TTAACGAG 52.0% identity Open · Scan
MA0893.1 NN 70-40% JASPAR ACTAATTAAA 52.0% identity Open · Scan
M06261_2.00 NN 70-40% CisBP TTAATTA 51.9% identity Open · Scan
M00376_2.00 NN 70-40% CisBP TCAAGTGCTT 51.7% identity Open · Scan
MA0063.1 NN 70-40% JASPAR TTAATTG 51.6% identity Open · Scan
MA0063.2 NN 70-40% JASPAR ACCACTCAAAA 51.6% identity Open · Scan
MA0122.1 NN 70-40% JASPAR TTAAGTGGA 51.6% identity Open · Scan
MA0122.2 NN 70-40% JASPAR ACCACTTAA 51.6% identity Open · Scan
M01250_2.00 NN 70-40% CisBP TCAATAATTG 51.0% identity Open · Scan
M02187_2.00 NN 70-40% CisBP AGTAATTACT 50.9% identity Open · Scan
M03104_2.00 NN 70-40% CisBP TTAATTACGGTAATTAC 50.9% identity Open · Scan
M03271_2.00 NN 70-40% CisBP GTAATTAC 50.9% identity Open · Scan
M03887_2.00 NN 70-40% CisBP GATAATCGATTATC 50.9% identity Open · Scan
M03896_2.00 NN 70-40% CisBP CTAATTAG 50.9% identity Open · Scan
M03903_2.00 NN 70-40% CisBP ATAATTGATTAT 50.9% identity Open · Scan
M06224_2.00 NN 70-40% CisBP ATCATAAAA 50.9% identity Open · Scan
M06914_2.00 NN 70-40% CisBP ACAATAATTGA 50.9% identity Open · Scan
MA0706.1 NN 70-40% JASPAR AGTAATTAAC 50.9% identity Open · Scan
MA1496.1 NN 70-40% JASPAR GTCATTAG 50.9% identity Open · Scan
M00388_2.00 NN 70-40% CisBP CTAATTGCTT 50.8% identity Open · Scan
M06323_2.00 NN 70-40% CisBP ATTAATTG 50.8% identity Open · Scan
MA0707.1 NN 70-40% JASPAR GGTAATTAAA 50.8% identity Open · Scan
M06286_2.00 NN 70-40% CisBP CTTAAGTG 50.7% identity Open · Scan
M00385_2.00 NN 70-40% CisBP TTAAGTGG 50.0% identity Open · Scan
M00464_2.00 NN 70-40% CisBP CTAATTACC 50.0% identity Open · Scan
M02074_2.00 NN 70-40% CisBP GTAATATA 50.0% identity Open · Scan
M02205_2.00 NN 70-40% CisBP CATTAATTACC 50.0% identity Open · Scan
M09146_2.00 NN 70-40% CisBP CTTGAGTGGC 50.0% identity Open · Scan
MA0465.1 NN 70-40% JASPAR AAGCCATAAAA 50.0% identity Open · Scan
MA0666.1 NN 70-40% JASPAR CCAATTAG 50.0% identity Open · Scan
MA0708.1 NN 70-40% JASPAR CCAATTAA 50.0% identity Open · Scan
MA0709.1 NN 70-40% JASPAR CCAATTAA 50.0% identity Open · Scan
MA0722.1 NN 70-40% JASPAR CTAATTAC 50.0% identity Open · Scan
MA0723.1 NN 70-40% JASPAR CTAATTAC 50.0% identity Open · Scan
MA1473.1 NN 70-40% JASPAR GGCAATAAAAC 50.0% identity Open · Scan
ModCRE8
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_sp_Q03014_HHEX_HUMAN:137:191_3rkq_B_1 ModCRE Homology model GTAATTGCCCCCCACTTTA Region 137-191 · 1 3D model Open · Scan
DIMER_sp_Q03014_HHEX_HUMAN:140:206_4uus_A_1 ModCRE Homology model GGCCATTAATTGG Region 140-206 · 1 3D model Open · Scan
DIMER_sp_Q03014_HHEX_HUMAN:141:191_4s0h_F_1 ModCRE Homology model AGCCGGCCACAAATTGGGA Region 141-191 · 1 3D model Open · Scan
DIMER_sp_Q03014_HHEX_HUMAN:141:198_1b72_A_1 ModCRE Homology model GGGGCAATTAATTATGGCA Region 141-198 · 1 3D model Open · Scan
DIMER_sp_Q03014_HHEX_HUMAN:144:191_5zjt_A_1 ModCRE Homology model GCCATTCATTTTGA Region 144-191 · 1 3D model Open · Scan
TFS_sp_Q03014_HHEX_HUMAN:140:206_4uus_A_1 ModCRE Homology model GGCAATTTATTGT Region 140-206 · 1 3D model Open · Scan
TFS_sp_Q03014_HHEX_HUMAN:141:207_6es2_K_1 ModCRE Homology model CGGCAATATATGAGGCCA Region 141-207 · 1 3D model Open · Scan
TFS_sp_Q03014_HHEX_HUMAN:144:194_9ant_A_1 ModCRE Homology model TGGCCCAATTAGCC Region 144-194 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 270 aa
128-207

Region 128-207 8 PWM

Residues
80 aa
Domains
PF00046 · Homeodomain
3D models
15 active PDBs · 10 summary rows
Templates
1AHD, 1B72, 1PUF, 2H1K, 2ME6, 3A01, 3RKQ, 4S0H, ...
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
15 active PDB models 10 summary rows
Region 128-20715 models · 10 summary rows
Actions
Predicted = Low DIMER_sp_Q03014_HHEX_HUMAN:128:198_3a01_A_1 3a01 128-198 View model · PDB
Predicted = Low DIMER_sp_Q03014_HHEX_HUMAN:137:191_3rkq_B_1 3rkq 137-191 View model · PDB
Predicted = Low DIMER_sp_Q03014_HHEX_HUMAN:140:206_4uus_A_1 4uus 140-206 View model · PDB
Predicted = Low DIMER_sp_Q03014_HHEX_HUMAN:141:191_4s0h_F_1 4s0h 141-191 View model · PDB
Predicted = Low DIMER_sp_Q03014_HHEX_HUMAN:141:198_1b72_A_1 1b72 141-198 View model · PDB
Predicted = Low DIMER_sp_Q03014_HHEX_HUMAN:144:191_5zjt_A_1 5zjt 144-191 View model · PDB
Predicted = Low DIMER_sp_Q03014_HHEX_HUMAN:144:198_1puf_A_1 1puf 144-198 View model · PDB
Predicted = Low TFS_sp_Q03014_HHEX_HUMAN:128:198_3a01_A_1 3a01 128-198 View model · PDB
Predicted = Low TFS_sp_Q03014_HHEX_HUMAN:133:199_2me6_A_1 2me6 133-199 View model · PDB
Predicted = Low TFS_sp_Q03014_HHEX_HUMAN:137:194_1ahd_P_1 1ahd 137-194 View model · PDB
Predicted = Low TFS_sp_Q03014_HHEX_HUMAN:138:194_4xic_A_1 4xic 138-194 View model · PDB
Predicted = Low TFS_sp_Q03014_HHEX_HUMAN:140:206_4uus_A_1 4uus 140-206 View model · PDB
Predicted = Low TFS_sp_Q03014_HHEX_HUMAN:141:207_6es2_K_1 6es2 141-207 View model · PDB
Predicted = Low TFS_sp_Q03014_HHEX_HUMAN:144:194_2h1k_A_1 2h1k 144-194 View model · PDB
Predicted = Low TFS_sp_Q03014_HHEX_HUMAN:144:194_9ant_A_1 9ant 144-194 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
3 3rkq 128:207 137,137 191,191 P:A,B · DNA:C,D 54.5% / 72.7% 94,96 View · PDB DIMER_sp_Q03014_HHEX_HUMAN:137:191_3rkq_B_1
3 2h1k 128:207 144 194 P:A · DNA:C,D 52.9% / 70.6% 87 View · PDB TFS_sp_Q03014_HHEX_HUMAN:144:194_2h1k_A_1
1 2me6 128:207 133 199 P:A · DNA:B,C 52.2% / 71.6% 94 View · PDB TFS_sp_Q03014_HHEX_HUMAN:133:199_2me6_A_1
1 3a01 128:207 128,144 198,194 P:A,B · DNA:C,D 50.7% / 64.8% 91,89 View · PDB DIMER_sp_Q03014_HHEX_HUMAN:128:198_3a01_A_1
2 3a01 128:207 128,144 198,194 P:A,B · DNA:C,D 50.7% / 64.8% 91,89 View · PDB TFS_sp_Q03014_HHEX_HUMAN:128:198_3a01_A_1
4 1ahd 128:207 137 194 P:P · DNA:A,B 48.3% / 69.0% 85 View · PDB TFS_sp_Q03014_HHEX_HUMAN:137:194_1ahd_P_1
5 4xic 128:207 138 194 P:A · DNA:B,C 47.4% / 68.4% 96 View · PDB TFS_sp_Q03014_HHEX_HUMAN:138:194_4xic_A_1
5 1b72 128:207 141,161 198,194 P:A,B · DNA:D,E 46.6% / 63.8% 85,46 View · PDB DIMER_sp_Q03014_HHEX_HUMAN:141:198_1b72_A_1
4 1puf 128:207 144,161 198,194 P:A,B · DNA:D,E 45.5% / 70.9% 71,46 View · PDB DIMER_sp_Q03014_HHEX_HUMAN:144:198_1puf_A_1
2 4uus 128:207 140,161 206,194 P:A,B · DNA:C,D 43.3% / 64.2% 100,49 View · PDB DIMER_sp_Q03014_HHEX_HUMAN:140:206_4uus_A_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
142-194PF00046Homeodomainoverlaps 128-207