ModCRE DB

Transcription factor

Q12870 - TCF15

Transcription factor 15 (TCF-15) (Class A basic helix-loop-helix protein 40) (bHLHa40) (Paraxis) (Protein bHLH-EC2)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 199 aa

32 Generated PWM 10 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)22
MotifPredictionSourceDNA bindingSupportLogoActions
M01718_2.00 NN 70-40% CisBP AACATATGGT 62.5% identity Open · Scan
MA0633.1 NN 70-40% JASPAR ACCATATGTT 62.5% identity Open · Scan
MA1123.1 NN 70-40% JASPAR ATTCCAGATGTTT 62.5% identity Open · Scan
MA0092.1 NN 70-40% JASPAR GGTCTGGCAT 61.2% identity Open · Scan
MA0665.1 NN 70-40% JASPAR AACAGCTGTT 58.9% identity Open · Scan
MA0832.1 NN 70-40% JASPAR GCAACAGCTGTTGT 58.9% identity Open · Scan
MA1568.1 NN 70-40% JASPAR CACCATATGGCG 58.9% identity Open · Scan
MA1638.1 NN 70-40% JASPAR ACCAGATGGC 58.6% identity Open · Scan
MA0091.1 NN 70-40% JASPAR CGACCATCTGTT 55.5% identity Open · Scan
MA0140.1 NN 70-40% JASPAR CTGGTGGGGACAGATAAG 55.5% identity Open · Scan
M04156_2.00 NN 70-40% CisBP AACAGCTGACGC 54.5% identity Open · Scan
MA1618.1 NN 70-40% JASPAR AAACAGATGTTTA 54.5% identity Open · Scan
MA1468.1 NN 70-40% JASPAR AACATATGTC 52.5% identity Open · Scan
M05980_2.00 NN 70-40% CisBP CACAGCTGAC 51.5% identity Open · Scan
M06000_2.00 NN 70-40% CisBP CCAGATGGCACGGACACAACA 50.5% identity Open · Scan
M00756_2.00 NN 70-40% CisBP CGCAGCTGTG 50.0% identity Open · Scan
M05962_2.00 NN 70-40% CisBP CCACCTGCC 50.0% identity Open · Scan
MA0048.1 NN 70-40% JASPAR GCGCAGCTGCGT 50.0% identity Open · Scan
MA0623.1 NN 70-40% JASPAR ACCATATGGT 50.0% identity Open · Scan
MA0623.2 NN 70-40% JASPAR GACATATGTC 50.0% identity Open · Scan
MA0669.1 NN 70-40% JASPAR AACATATGTC 50.0% identity Open · Scan
MA1529.1 NN 70-40% JASPAR GGGCCGCAGCTGCGTCCC 50.0% identity Open · Scan
ModCRE10
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_sp_Q12870_TCF15_HUMAN:73:121_5i50_B_1 ModCRE Homology model GGGGGTCCCACGTGGCACCCCA Region 73-121 · 1 3D model Open · Scan
DIMER_sp_Q12870_TCF15_HUMAN:73:124_7z5i_B_1 ModCRE Homology model TATAAACATATGGTTAGA Region 73-124 · 1 3D model Open · Scan
DIMER_sp_Q12870_TCF15_HUMAN:73:124_7z5k_B_1 ModCRE Homology model ATGAAACATATGGGCAGC Region 73-124 · 1 3D model Open · Scan
DIMER_sp_Q12870_TCF15_HUMAN:74:121_8osl_N_1 ModCRE Homology model CGGGTCACAGCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACACATGAAAAATTTTGCAAAACAATATG Region 74-121 · 1 3D model Open · Scan
DIMER_sp_Q12870_TCF15_HUMAN:81:124_7ssa_L_1 ModCRE Homology model ACGCGTGTGCACCAATGGCTCAACCACACAATTCACAGCTCCCTCACACTACCCCTGACAGCTACCCAGGTCCAAGAATTCCTGA Region 81-124 · 1 3D model Open · Scan
TFS_sp_Q12870_TCF15_HUMAN:66:128_2ypb_A_1 ModCRE Homology model CTGCATATGGT Region 66-128 · 1 3D model Open · Scan
TFS_sp_Q12870_TCF15_HUMAN:67:128_2ypa_A_1 ModCRE Homology model GTCCATATGGG Region 67-128 · 1 3D model Open · Scan
TFS_sp_Q12870_TCF15_HUMAN:73:124_7z5i_B_1 ModCRE Homology model TATAAACATATGTTTATA Region 73-124 · 1 3D model Open · Scan
TFS_sp_Q12870_TCF15_HUMAN:73:124_7z5k_B_1 ModCRE Homology model GCTGCACATATGTTTCAG Region 73-124 · 1 3D model Open · Scan
TFS_sp_Q12870_TCF15_HUMAN:73:128_2ql2_B_1 ModCRE Homology model GTAAGCATATTTTGAA Region 73-128 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 199 aa
66-128

Region 66-128 10 PWM

Residues
63 aa
Domains
PF00010 · Helix-loop-helix DNA-binding domain
3D models
10 active PDBs · 10 summary rows
Templates
2QL2, 2YPA, 2YPB, 5I50, 7SSA, 7Z5I, 7Z5K, 8OSL
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
10 active PDB models 10 summary rows
Region 66-12810 models · 10 summary rows
Actions
Predicted = Low DIMER_sp_Q12870_TCF15_HUMAN:73:121_5i50_B_1 5i50 73-121 View model · PDB
Predicted = Low DIMER_sp_Q12870_TCF15_HUMAN:73:124_7z5i_B_1 7z5i 73-124 View model · PDB
Predicted = Low DIMER_sp_Q12870_TCF15_HUMAN:73:124_7z5k_B_1 7z5k 73-124 View model · PDB
Predicted = Low DIMER_sp_Q12870_TCF15_HUMAN:74:121_8osl_N_1 8osl 74-121 View model · PDB
Predicted = Low DIMER_sp_Q12870_TCF15_HUMAN:81:124_7ssa_L_1 7ssa 81-124 View model · PDB
Predicted = Low TFS_sp_Q12870_TCF15_HUMAN:66:128_2ypb_A_1 2ypb 66-128 View model · PDB
Predicted = Low TFS_sp_Q12870_TCF15_HUMAN:67:128_2ypa_A_1 2ypa 67-128 View model · PDB
Predicted = Low TFS_sp_Q12870_TCF15_HUMAN:73:124_7z5i_B_1 7z5i 73-124 View model · PDB
Predicted = Low TFS_sp_Q12870_TCF15_HUMAN:73:124_7z5k_B_1 7z5k 73-124 View model · PDB
Predicted = Low TFS_sp_Q12870_TCF15_HUMAN:73:128_2ql2_B_1 2ql2 73-128 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
1 2ypb 66:128 66 128 P:A · DNA:E,F 55.6% / 65.1% 94 View · PDB TFS_sp_Q12870_TCF15_HUMAN:66:128_2ypb_A_1
2 2ypa 66:128 67 128 P:A · DNA:E,F 54.8% / 64.5% 92 View · PDB TFS_sp_Q12870_TCF15_HUMAN:67:128_2ypa_A_1
3 2ql2 66:128 73 128 P:B · DNA:E,F 48.2% / 66.1% 94 View · PDB TFS_sp_Q12870_TCF15_HUMAN:73:128_2ql2_B_1
1 7z5k 66:128 73,73 124,124 P:A,B · DNA:E,F 42.3% / 59.6% 91,91 View · PDB DIMER_sp_Q12870_TCF15_HUMAN:73:124_7z5k_B_1
2 7z5i 66:128 73,73 124,124 P:A,B · DNA:E,F 42.3% / 59.6% 91,91 View · PDB DIMER_sp_Q12870_TCF15_HUMAN:73:124_7z5i_B_1
4 7z5k 66:128 73,73 124,124 P:A,B · DNA:E,F 42.3% / 59.6% 91,91 View · PDB TFS_sp_Q12870_TCF15_HUMAN:73:124_7z5k_B_1
5 7z5i 66:128 73,73 124,124 P:A,B · DNA:E,F 42.3% / 59.6% 91,91 View · PDB TFS_sp_Q12870_TCF15_HUMAN:73:124_7z5i_B_1
5 7ssa 66:128 81,81 124,124 P:K,L · DNA:I,J 36.4% / 52.3% 59,59 View · PDB DIMER_sp_Q12870_TCF15_HUMAN:81:124_7ssa_L_1
3 5i50 66:128 73,73 121,121 P:A,B · DNA:C,D 32.7% / 53.1% 53,51 View · PDB DIMER_sp_Q12870_TCF15_HUMAN:73:121_5i50_B_1
4 8osl 66:128 74,74 121,121 P:N,P · DNA:I,J 30.6% / 57.1% 16,96 View · PDB DIMER_sp_Q12870_TCF15_HUMAN:74:121_8osl_N_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
73-124PF00010Helix-loop-helix DNA-binding domainoverlaps 66-128