ModCRE DB

Transcription factor

Q13950 - RUNX2

Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 521 aa

10 Generated PWM 1 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known10
MotifPredictionSourceDNA bindingSupportLogoActions
MA0511.1 Known JASPAR GGGGTTTGTGGTTTG Direct PWM Open · Scan
MA0511.2 Known JASPAR AAACCGCAA Direct PWM Open · Scan
M03468_2.00 Known CisBP TAACCGCAAACCGCAA Direct PWM Open · Scan
M03469_2.00 Known CisBP TAACCGCAAAAACCGCAA Direct PWM Open · Scan
M03470_2.00 Known CisBP AAACCGCAA Direct PWM Open · Scan
M05733_2.00 Known CisBP CTAACCGCAAAAACCGCAAC Direct PWM Open · Scan
M05734_2.00 Known CisBP CAAACCACAAAAACCACAAA Direct PWM Open · Scan
M09370_2.00 Known CisBP AAAAACCACAGACA Direct PWM Open · Scan
M09630_2.00 Known CisBP CAAACCACAAAC Direct PWM Open · Scan
RUNX2_HUMAN.H11MO.0.A Known HOCOMOCO TGTCTGTGGTTTGT Direct PWM Open · Scan
Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)0

No generated PWM in this category.

ModCRE0

No generated PWM in this category.

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 521 aa
101-228

Region 101-228 0 PWM

Residues
128 aa
Domains
PF00853 · Runt domain
3D models
1 active PDB
Templates
4L0Y
Sources
Structure model
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
1 active PDB model
Region 101-2281 model
Actions
Predicted = Low TFS_Q13950:101:228_4l0y_A_1 4l0y 101-228 View model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
103-230PF00853Runt domainoverlaps 101-228
430-521PF08504Runx inhibition domainNo overlap with loaded model regions