ModCRE DB

Transcription factor

Q14190 - SIM2

Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 667 aa

14 Generated PWM 14 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)0

No generated PWM in this category.

ModCRE14
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_sp_Q14190_SIM2_HUMAN:2:332_8osk_N_1 ModCRE Homology model TCCCCGGGGGCTCAAGCGAACAAGTGGGGAAACTAAAACGAGATTACATTTCAGGCATTCACAAAGCTATAGGTTATTCCTGCGCACGGGGGATACGCGA Region 2-332 · 1 3D model Open · Scan
DIMER_sp_Q14190_SIM2_HUMAN:2:332_8osl_N_1 ModCRE Homology model ACACGGGGGTCCGCGATGTCGCTCCGTCCACGCAGCACACTAACGACGCCTGACGTGAAAGCGACGTCTAAGTAGCTTATAGGGCGGTGGGTATATCCCTGTC Region 2-332 · 1 3D model Open · Scan
DIMER_sp_Q14190_SIM2_HUMAN:2:335_4zpr_B_1 ModCRE Homology model CGCCCGCACGTGGACAC Region 2-335 · 1 3D model Open · Scan
DIMER_sp_Q14190_SIM2_HUMAN:2:346_4zpk_B_1 ModCRE Homology model CCACGTCGTGCGCGT Region 2-346 · 1 3D model Open · Scan
DIMER_sp_Q14190_SIM2_HUMAN:2:347_5sy7_B_1 ModCRE Homology model CGGCCGCGTCGTGTGCAC Region 2-347 · 1 3D model Open · Scan
TFS_sp_Q14190_SIM2_HUMAN:2:141_4zpk_A_1 ModCRE Homology model GTGCACACGAGTGTG Region 2-141 · 1 3D model Open · Scan
TFS_sp_Q14190_SIM2_HUMAN:2:141_5sy7_A_1 ModCRE Homology model GTGCACACGACGTGCCCC Region 2-141 · 1 3D model Open · Scan
TFS_sp_Q14190_SIM2_HUMAN:2:141_5v0l_A_1 ModCRE Homology model TTGCAAACAGT Region 2-141 · 1 3D model Open · Scan
TFS_sp_Q14190_SIM2_HUMAN:2:332_8osk_N_1 ModCRE Homology model AAGCGGATCCCCCGTGCACAAAAAAGCCCACCGGGGAATATAAAAAATGGTGGCAGTCACAATTCTGTACAAATACGCTAACTAGTAGGCCCCCCGGGGA Region 2-332 · 1 3D model Open · Scan
TFS_sp_Q14190_SIM2_HUMAN:2:332_8osl_N_1 ModCRE Homology model CACATGGGGATGCGCCGTGCGGCCTGAAAATCCCCCCCTCGATTCTAAAGGCTTCGACTTAAGATGGGCAATCAGCCCAACGGAAGATAATGGACCCCCGGGA Region 2-332 · 1 3D model Open · Scan
TFS_sp_Q14190_SIM2_HUMAN:2:335_4zpr_B_1 ModCRE Homology model CCCCGGCACTGTGGCAC Region 2-335 · 1 3D model Open · Scan
TFS_sp_Q14190_SIM2_HUMAN:2:346_4zpk_B_1 ModCRE Homology model CCGCGTCGCGCGCGT Region 2-346 · 1 3D model Open · Scan
TFS_sp_Q14190_SIM2_HUMAN:2:347_5sy7_B_1 ModCRE Homology model CGGCCGCGTCGTGTGCAC Region 2-347 · 1 3D model Open · Scan
TFS_sp_Q14190_SIM2_HUMAN:7:135_5nj8_A_1 ModCRE Homology model GCACACTGAAAG Region 7-135 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 667 aa
2-347

Region 2-347 14 PWM

Residues
346 aa
Domains
PF23171 · Hypoxia-inducible factor 1-alpha bHLH domain PF00989 · PAS fold PF08447 · PAS fold
3D models
14 active PDBs · 10 summary rows
Templates
4ZPK, 4ZPR, 5NJ8, 5SY7, 5V0L, 8OSK, 8OSL
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
14 active PDB models 10 summary rows
Region 2-34714 models · 10 summary rows
Actions
Predicted = Low DIMER_sp_Q14190_SIM2_HUMAN:2:332_8osk_N_1 8osk 2-332 View model · PDB
Predicted = Low DIMER_sp_Q14190_SIM2_HUMAN:2:332_8osl_N_1 8osl 2-332 View model · PDB
Predicted = Low DIMER_sp_Q14190_SIM2_HUMAN:2:335_4zpr_B_1 4zpr 2-335 View model · PDB
Predicted = Low DIMER_sp_Q14190_SIM2_HUMAN:2:346_4zpk_B_1 4zpk 2-346 View model · PDB
Predicted = Low DIMER_sp_Q14190_SIM2_HUMAN:2:347_5sy7_B_1 5sy7 2-347 View model · PDB
Predicted = Low TFS_sp_Q14190_SIM2_HUMAN:2:141_4zpk_A_1 4zpk 2-141 View model · PDB
Predicted = Low TFS_sp_Q14190_SIM2_HUMAN:2:141_5sy7_A_1 5sy7 2-141 View model · PDB
Predicted = Low TFS_sp_Q14190_SIM2_HUMAN:2:141_5v0l_A_1 5v0l 2-141 View model · PDB
Predicted = Low TFS_sp_Q14190_SIM2_HUMAN:2:332_8osk_N_1 8osk 2-332 View model · PDB
Predicted = Low TFS_sp_Q14190_SIM2_HUMAN:2:332_8osl_N_1 8osl 2-332 View model · PDB
Predicted = Low TFS_sp_Q14190_SIM2_HUMAN:2:335_4zpr_B_1 4zpr 2-335 View model · PDB
Predicted = Low TFS_sp_Q14190_SIM2_HUMAN:2:346_4zpk_B_1 4zpk 2-346 View model · PDB
Predicted = Low TFS_sp_Q14190_SIM2_HUMAN:2:347_5sy7_B_1 5sy7 2-347 View model · PDB
Predicted = Low TFS_sp_Q14190_SIM2_HUMAN:7:135_5nj8_A_1 5nj8 7-135 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
2 4zpr 2:347 2,2 141,335 P:A,B · DNA:C,D 39.2% / 58.8% 48,96 View · PDB DIMER_sp_Q14190_SIM2_HUMAN:2:335_4zpr_B_1
2 4zpr 2:347 2,2 141,335 P:A,B · DNA:C,D 39.2% / 58.8% 48,96 View · PDB TFS_sp_Q14190_SIM2_HUMAN:2:335_4zpr_B_1
1 5sy7 2:347 2,2 141,347 P:A,B · DNA:C,D 38.1% / 52.3% 44,98 View · PDB DIMER_sp_Q14190_SIM2_HUMAN:2:347_5sy7_B_1
1 5sy7 2:347 2,2 141,347 P:A,B · DNA:C,D 38.1% / 52.3% 44,98 View · PDB TFS_sp_Q14190_SIM2_HUMAN:2:141_5sy7_A_1
3 4zpk 2:347 2,2 141,346 P:A,B · DNA:C,D 35.1% / 56.9% 45,95 View · PDB DIMER_sp_Q14190_SIM2_HUMAN:2:346_4zpk_B_1
3 4zpk 2:347 2,2 141,346 P:A,B · DNA:C,D 35.1% / 56.9% 45,95 View · PDB TFS_sp_Q14190_SIM2_HUMAN:2:346_4zpk_B_1
4 8osk 2:347 78,2 338,332 P:M,N · DNA:I,J 26.1% / 41.9% 78,94 View · PDB DIMER_sp_Q14190_SIM2_HUMAN:2:332_8osk_N_1
4 8osk 2:347 78,2 338,332 P:M,N · DNA:I,J 26.1% / 41.9% 78,94 View · PDB TFS_sp_Q14190_SIM2_HUMAN:2:332_8osk_N_1
5 8osl 2:347 2,2 332,50 P:N,P · DNA:I,J 26.1% / 41.9% 92,98 View · PDB DIMER_sp_Q14190_SIM2_HUMAN:2:332_8osl_N_1
5 8osl 2:347 2,2 332,50 P:N,P · DNA:I,J 26.1% / 41.9% 92,98 View · PDB TFS_sp_Q14190_SIM2_HUMAN:2:332_8osl_N_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
2-57PF23171Hypoxia-inducible factor 1-alpha bHLH domainoverlaps 2-347
81-142PF00989PAS foldoverlaps 2-347
243-329PF08447PAS foldoverlaps 2-347
358-660PF06621Single-minded protein C-terminusNo overlap with loaded model regions