ModCRE DB

Transcription factor

Q14582 - MXD4

Max dimerization protein 4 (Max dimerizer 4) (Class C basic helix-loop-helix protein 12) (bHLHc12) (Max-associated protein 4) (Max-interacting transcriptional repressor MAD4)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 209 aa

14 Generated PWM 13 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)2
MotifPredictionSourceDNA bindingSupportLogoActions
M08051_2.00 NN 70-40% CisBP CGACCACGTGCCC 58.7% identity Open · Scan
MA1108.1 NN 70-40% JASPAR CGACCACGTGCCC 52.6% identity Open · Scan
ModCRE12
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_sp_Q14582_MAD4_HUMAN:55:111_1an4_B_1 ModCRE Homology model TTGGGGACCCGTGGAGAACC Region 55-111 · 1 3D model Open · Scan
DIMER_sp_Q14582_MAD4_HUMAN:55:133_8ia3_A_1 ModCRE Homology model GACACCATATTTTTATAA Region 55-133 · 1 3D model Open · Scan
DIMER_sp_Q14582_MAD4_HUMAN:55:133_8ia3_B_1 ModCRE Homology model GTGCAAACATTTTGAAAA Region 55-133 · 1 3D model Open · Scan
DIMER_sp_Q14582_MAD4_HUMAN:55:133_8ia3_E_1 ModCRE Homology model GGGCGCCCGGGGTGGCCC Region 55-133 · 1 3D model Open · Scan
TFS_sp_Q14582_MAD4_HUMAN:53:105_4h10_A_1 ModCRE Homology model GGAGCACGATGCCC Region 53-105 · 1 3D model Open · Scan
TFS_sp_Q14582_MAD4_HUMAN:54:132_1nlw_A_1 ModCRE Homology model TTGACACACGTGGGCCCC Region 54-132 · 1 3D model Open · Scan
TFS_sp_Q14582_MAD4_HUMAN:55:105_5v0l_A_1 ModCRE Homology model GGGGGCCCACC Region 55-105 · 1 3D model Open · Scan
TFS_sp_Q14582_MAD4_HUMAN:55:111_1an4_A_1 ModCRE Homology model TGGCCACCCCATGGCCTAAA Region 55-111 · 1 3D model Open · Scan
TFS_sp_Q14582_MAD4_HUMAN:55:111_1an4_B_1 ModCRE Homology model TTGGGGACCCGTGGAGAACC Region 55-111 · 1 3D model Open · Scan
TFS_sp_Q14582_MAD4_HUMAN:55:133_8ia3_A_1 ModCRE Homology model GCCAACATATTTTTATAA Region 55-133 · 1 3D model Open · Scan
TFS_sp_Q14582_MAD4_HUMAN:55:133_8ia3_B_1 ModCRE Homology model GCGCAAACATTTTGAAAA Region 55-133 · 1 3D model Open · Scan
TFS_sp_Q14582_MAD4_HUMAN:55:133_8ia3_E_1 ModCRE Homology model GGGCCACCCCGGGCGCCA Region 55-133 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 209 aa
53-133

Region 53-133 12 PWM

Residues
81 aa
Domains
PF00010 · Helix-loop-helix DNA-binding domain
3D models
13 active PDBs · 10 summary rows
Templates
1AN4, 1NLW, 4H10, 5I50, 5V0L, 8IA3
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
13 active PDB models 10 summary rows
Region 53-13313 models · 10 summary rows
Actions
Predicted = Low DIMER_sp_Q14582_MAD4_HUMAN:55:111_1an4_B_1 1an4 55-111 View model · PDB
Predicted = Low DIMER_sp_Q14582_MAD4_HUMAN:55:133_5i50_B_1 5i50 55-133 View model · PDB
Predicted = Low DIMER_sp_Q14582_MAD4_HUMAN:55:133_8ia3_A_1 8ia3 55-133 View model · PDB
Predicted = Low DIMER_sp_Q14582_MAD4_HUMAN:55:133_8ia3_B_1 8ia3 55-133 View model · PDB
Predicted = Low DIMER_sp_Q14582_MAD4_HUMAN:55:133_8ia3_E_1 8ia3 55-133 View model · PDB
Predicted = Low TFS_sp_Q14582_MAD4_HUMAN:53:105_4h10_A_1 4h10 53-105 View model · PDB
Predicted = Low TFS_sp_Q14582_MAD4_HUMAN:54:132_1nlw_A_1 1nlw 54-132 View model · PDB
Predicted = Low TFS_sp_Q14582_MAD4_HUMAN:55:105_5v0l_A_1 5v0l 55-105 View model · PDB
Predicted = Low TFS_sp_Q14582_MAD4_HUMAN:55:111_1an4_A_1 1an4 55-111 View model · PDB
Predicted = Low TFS_sp_Q14582_MAD4_HUMAN:55:111_1an4_B_1 1an4 55-111 View model · PDB
Predicted = Low TFS_sp_Q14582_MAD4_HUMAN:55:133_8ia3_A_1 8ia3 55-133 View model · PDB
Predicted = Low TFS_sp_Q14582_MAD4_HUMAN:55:133_8ia3_B_1 8ia3 55-133 View model · PDB
Predicted = Low TFS_sp_Q14582_MAD4_HUMAN:55:133_8ia3_E_1 8ia3 55-133 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
1 1nlw 50:141 54 132 P:A · DNA:F,G 68.4% / 87.3% 100 View · PDB TFS_sp_Q14582_MAD4_HUMAN:54:132_1nlw_A_1
4 1an4 50:141 55,55 111,111 P:A,B · DNA:C,D 30.0% / 61.7% 87,87 View · PDB DIMER_sp_Q14582_MAD4_HUMAN:55:111_1an4_B_1
5 1an4 50:141 55,55 111,111 P:A,B · DNA:C,D 30.0% / 61.7% 87,87 View · PDB TFS_sp_Q14582_MAD4_HUMAN:55:111_1an4_A_1
1 8ia3 50:141 55,55 133,133 P:A,F · DNA:G,H 28.2% / 57.6% 73,75 View · PDB DIMER_sp_Q14582_MAD4_HUMAN:55:133_8ia3_A_1
2 8ia3 50:141 55,55 133,133 P:A,F · DNA:G,H 28.2% / 57.6% 73,75 View · PDB TFS_sp_Q14582_MAD4_HUMAN:55:133_8ia3_A_1
2 8ia3 50:141 55,55 133,133 P:E,F · DNA:G,H 28.2% / 57.6% 71,75 View · PDB DIMER_sp_Q14582_MAD4_HUMAN:55:133_8ia3_E_1
3 8ia3 50:141 55,55 133,133 P:E,F · DNA:G,H 28.2% / 57.6% 71,75 View · PDB TFS_sp_Q14582_MAD4_HUMAN:55:133_8ia3_E_1
3 8ia3 50:141 55,55 133,133 P:B,F · DNA:G,H 28.2% / 57.6% 79,75 View · PDB DIMER_sp_Q14582_MAD4_HUMAN:55:133_8ia3_B_1
4 8ia3 50:141 55,55 133,133 P:B,F · DNA:G,H 28.2% / 57.6% 79,75 View · PDB TFS_sp_Q14582_MAD4_HUMAN:55:133_8ia3_B_1
5 5i50 50:141 55,55 133,133 P:A,B · DNA:C,D 27.8% / 59.5% 85,82 View · PDB DIMER_sp_Q14582_MAD4_HUMAN:55:133_5i50_B_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
55-106PF00010Helix-loop-helix DNA-binding domainoverlaps 53-133