ModCRE DB

Transcription factor

Q16665 - HIF1A

Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 826 aa

8 Generated PWM 1 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known8
MotifPredictionSourceDNA bindingSupportLogoActions
MA0259.1 Known JASPAR GGACGTGC Direct PWM Open · Scan
MA0259.2 Known JASPAR ACGTG Direct PWM Open · Scan
MA1106.1 Known JASPAR GTACGTGCCC Direct PWM Open · Scan
MA1106.2 Known JASPAR ACGTGC Direct PWM Open · Scan
M08049_2.00 Known CisBP GTACGTGCCC Direct PWM Open · Scan
M08713_2.00 Known CisBP GGACGTGC Direct PWM Open · Scan
M09454_2.00 Known CisBP TACGTGCC Direct PWM Open · Scan
HIF1A_HUMAN.H11MO.0.C Known HOCOMOCO GGACGTGC Direct PWM Open · Scan
Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)0

No generated PWM in this category.

ModCRE0

No generated PWM in this category.

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 826 aa
19-68

Region 19-68 0 PWM

Residues
50 aa
Domains
PF23171 · Hypoxia-inducible factor 1-alpha bHLH domain
3D models
1 active PDB
Templates
4H10
Sources
Structure model
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
1 active PDB model
Region 19-681 model
Actions
Predicted = Low DIMER_Q16665:19:68_4h10_A_1 4h10 19-68 View model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
1-80PF23171Hypoxia-inducible factor 1-alpha bHLH domainoverlaps 19-68
94-149PF00989PAS foldNo overlap with loaded model regions
254-339PF08447PAS foldNo overlap with loaded model regions
555-580PF11413Hypoxia-inducible factor-1No overlap with loaded model regions
790-825PF08778HIF-1 alpha C terminal transactivation domainNo overlap with loaded model regions