Transcription factor

Q2M218 - ZNF630

Zinc finger protein 630

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 657 aa

88 Generated PWM 12 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)78

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
M00944_2.00	NN 70-40%	CisBP	TCGCTATAA	69.4% identity		Open · Scan
M00953_2.00	NN 70-40%	CisBP	ATCTATAT	68.2% identity		Open · Scan
M00955_2.00	NN 70-40%	CisBP	ACGTCCTCT	68.2% identity		Open · Scan
M00943_2.00	NN 70-40%	CisBP	CCCGCTGC	67.0% identity		Open · Scan
M00952_2.00	NN 70-40%	CisBP	GGATGCTC	67.0% identity		Open · Scan
M00959_2.00	NN 70-40%	CisBP	GCCCTCCC	67.0% identity		Open · Scan
M00960_2.00	NN 70-40%	CisBP	TGCATCCC	67.0% identity		Open · Scan
M00939_2.00	NN 70-40%	CisBP	CCACCTCA	64.7% identity		Open · Scan
M00948_2.00	NN 70-40%	CisBP	GCAGCACC	64.7% identity		Open · Scan
M00950_2.00	NN 70-40%	CisBP	GCAGCCCA	64.7% identity		Open · Scan
M00958_2.00	NN 70-40%	CisBP	CGGCATCCC	63.5% identity		Open · Scan
MA1124.1	NN 70-40%	JASPAR	CATTCATTCATTC	63.3% identity		Open · Scan
M04387_2.00	NN 70-40%	CisBP	CGTGCTCCCC	63.0% identity		Open · Scan
M04653_2.00	NN 70-40%	CisBP	GGTACGGTTGTCCATGTTGCAA	62.5% identity		Open · Scan
M04611_2.00	NN 70-40%	CisBP	CTTTCGGACAC	62.2% identity		Open · Scan
M02924_2.00	NN 70-40%	CisBP	AGTGTTAACAGAACACCT	62.0% identity		Open · Scan
M07706_2.00	NN 70-40%	CisBP	GTCTTTGAGAGGGCCCAGATGTTGGACTTA	61.1% identity		Open · Scan
M07613_2.00	NN 70-40%	CisBP	TCACTCAGTCATTCA	60.9% identity		Open · Scan
M07610_2.00	NN 70-40%	CisBP	CCTTCTTCCTCCCCCCTGCCCACC	60.4% identity		Open · Scan
M08329_2.00	NN 70-40%	CisBP	GCTGCATAGTATTCC	60.3% identity		Open · Scan
M04650_2.00	NN 70-40%	CisBP	GCATAACTGCCCCGCTGCC	60.1% identity		Open · Scan
MA1154.1	NN 70-40%	JASPAR	CTTTCCCACAACACGAC	59.7% identity		Open · Scan
M08325_2.00	NN 70-40%	CisBP	TTTTTTTTT	59.4% identity		Open · Scan
M08267_2.00	NN 70-40%	CisBP	CAGTTTCATTTTCC	59.2% identity		Open · Scan
M07633_2.00	NN 70-40%	CisBP	CTCTCGTTGTGCCTTTGCCAT	58.8% identity		Open · Scan
M04598_2.00	NN 70-40%	CisBP	CGCTAACTCTCCACA	58.7% identity		Open · Scan
M04465_2.00	NN 70-40%	CisBP	GTGATTCTTATCTTATCCTT	58.5% identity		Open · Scan
M04613_2.00	NN 70-40%	CisBP	CTCATGTGCTAATTACAAA	58.0% identity		Open · Scan
M07578_2.00	NN 70-40%	CisBP	CAACTCTCC	58.0% identity		Open · Scan
M04505_2.00	NN 70-40%	CisBP	AGCTTTTCCCACAC	57.9% identity		Open · Scan
M08355_2.00	NN 70-40%	CisBP	GCGAACTCCTATTCATCC	57.5% identity		Open · Scan
M08901_2.00	NN 70-40%	CisBP	CCAGTTCACACC	57.1% identity		Open · Scan
M08309_2.00	NN 70-40%	CisBP	AAAAACCCCCCTGCAGAGCCCAGCCCT	56.9% identity		Open · Scan
M01456_2.00	NN 70-40%	CisBP	GTGATCGGCG	56.6% identity		Open · Scan
M04621_2.00	NN 70-40%	CisBP	AGCAATTCCGCTCA	56.3% identity		Open · Scan
M07562_2.00	NN 70-40%	CisBP	GAAAAAAAC	56.3% identity		Open · Scan
M07649_2.00	NN 70-40%	CisBP	CCCCCCCCCCCCTCAGGAATGCC	56.2% identity		Open · Scan
M08334_2.00	NN 70-40%	CisBP	TTTGTTTTTTTCTGATTGCTTTTTACTTAT	56.2% identity		Open · Scan
M08373_2.00	NN 70-40%	CisBP	CCCCCTGGCTCTTCCTCT	56.2% identity		Open · Scan
M08859_2.00	NN 70-40%	CisBP	CATTTTTTCCTCCTAGGCCT	56.1% identity		Open · Scan
M08365_2.00	NN 70-40%	CisBP	GCCAGCAGCCATCAG	56.0% identity		Open · Scan
M07691_2.00	NN 70-40%	CisBP	CCTGCAGCCACCTTGGCCTTG	55.7% identity		Open · Scan
M08887_2.00	NN 70-40%	CisBP	CCTCCTCCAGGAAGCCTTCCCTGA	55.7% identity		Open · Scan
M00142_2.00	NN 70-40%	CisBP	GTGCTCCT	55.6% identity		Open · Scan
M08375_2.00	NN 70-40%	CisBP	TTCCCCATTGGCTACTGCACCGGTCCT	55.6% identity		Open · Scan
M07753_2.00	NN 70-40%	CisBP	TGCATTCCTTGGCTTGTG	55.3% identity		Open · Scan
M08395_2.00	NN 70-40%	CisBP	GCTGCCTACTCTTCC	55.3% identity		Open · Scan
M04536_2.00	NN 70-40%	CisBP	ACGTAACCCGATACC	55.2% identity		Open · Scan
M08254_2.00	NN 70-40%	CisBP	CTGCCCTGGGACTTT	55.2% identity		Open · Scan
M00782_2.00	NN 70-40%	CisBP	AGTGTGCGCTA	55.0% identity		Open · Scan
M07660_2.00	NN 70-40%	CisBP	CCGCGCCTACCTGAGGGCGCGGGCCTGGGG	54.7% identity		Open · Scan
M07648_2.00	NN 70-40%	CisBP	GCTTGCAAAAAAAATTTAACTCCCAGCTC	54.4% identity		Open · Scan
M08247_2.00	NN 70-40%	CisBP	AAAAATAACAAACGG	54.4% identity		Open · Scan
M07620_2.00	NN 70-40%	CisBP	TTGGATCTGTGGATTCATGTCTTTCAT	53.7% identity		Open · Scan
M07667_2.00	NN 70-40%	CisBP	CCGCACAGGCCCCCGGGCCCC	53.6% identity		Open · Scan
M07587_2.00	NN 70-40%	CisBP	CCCCCTCCCCAGTCGAGCCCCCGC	53.4% identity		Open · Scan
M00786_2.00	NN 70-40%	CisBP	TATATATAT	53.3% identity		Open · Scan
M03671_2.00	NN 70-40%	CisBP	ATTACCATACAAGTGCAC	53.3% identity		Open · Scan
M07746_2.00	NN 70-40%	CisBP	CAGCTGGCGCCCAACATGGGTCCC	53.2% identity		Open · Scan
M08314_2.00	NN 70-40%	CisBP	ATTCATCAAGGTCCTCAACAATGG	53.2% identity		Open · Scan
M07600_2.00	NN 70-40%	CisBP	GCATTAGC	53.1% identity		Open · Scan
M08392_2.00	NN 70-40%	CisBP	CTTCACCTGCTGAGG	53.0% identity		Open · Scan
MA1602.1	NN 70-40%	JASPAR	CGTCTACACGGG	53.0% identity		Open · Scan
MA1656.1	NN 70-40%	JASPAR	CCAAGCCCAACCAG	52.7% identity		Open · Scan
M00609_2.00	NN 70-40%	CisBP	GGAAGCCCTA	52.2% identity		Open · Scan
M05855_2.00	NN 70-40%	CisBP	GTATTATACCCAGCT	52.0% identity		Open · Scan
M07618_2.00	NN 70-40%	CisBP	CCTTTGGTGCTC	51.7% identity		Open · Scan
M08311_2.00	NN 70-40%	CisBP	CTGGAACAGAAGGGGCGA	51.4% identity		Open · Scan
M07702_2.00	NN 70-40%	CisBP	CTTCTTCCTTGG	51.3% identity		Open · Scan
M07656_2.00	NN 70-40%	CisBP	TGTCTAGTAAGTCTA	51.1% identity		Open · Scan
M07775_2.00	NN 70-40%	CisBP	GCCGAAACCCGGG	50.9% identity		Open · Scan
M00134_2.00	NN 70-40%	CisBP	GCCACGCCCA	50.8% identity		Open · Scan
M07623_2.00	NN 70-40%	CisBP	GTCTAATAGAGCTGGGCTGCA	50.7% identity		Open · Scan
M05844_2.00	NN 70-40%	CisBP	TCACCTGT	50.6% identity		Open · Scan
MA0528.1	NN 70-40%	JASPAR	GGAGGAGGAGGGGGAGGAGGA	50.4% identity		Open · Scan
M07678_2.00	NN 70-40%	CisBP	CCCGCCCCCTCCTCCCCCTTCCCACCC	50.1% identity		Open · Scan
M01474_2.00	NN 70-40%	CisBP	CGCCGATCAC	50.0% identity		Open · Scan
M07720_2.00	NN 70-40%	CisBP	TGTGTGTGTGGGCATGTGTGTGTGCGAGT	50.0% identity		Open · Scan

ModCRE10

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
TFS_sp_Q2M218_ZN630_HUMAN:173:289_5v3j_E_1	ModCRE	Homology model	CCCAGGGGACTCCGTCTTCA	Region 173-289 · 1 3D model		Open · Scan
TFS_sp_Q2M218_ZN630_HUMAN:173:289_5v3m_C_1	ModCRE	Homology model	GAAGCCGGCCGCCGGCCCCG	Region 173-289 · 1 3D model		Open · Scan
TFS_sp_Q2M218_ZN630_HUMAN:173:289_5wjq_D_1	ModCRE	Homology model	AAACCCCGCCCCCGGCCCCC	Region 173-289 · 1 3D model		Open · Scan
TFS_sp_Q2M218_ZN630_HUMAN:174:289_2i13_A_1	ModCRE	Homology model	ACCCCCCGCCTCCCCGGATTT	Region 174-289 · 1 3D model		Open · Scan
TFS_sp_Q2M218_ZN630_HUMAN:229:289_5eh2_F_1	ModCRE	Homology model	AAAACCGGGGCCCGA	Region 229-289 · 1 3D model		Open · Scan
TFS_sp_Q2M218_ZN630_HUMAN:290:566_5v3j_E_1	ModCRE	Homology model	CTCCTAGTTCCCTCCCCCCCCTGGC	Region 290-566 · 1 3D model		Open · Scan
TFS_sp_Q2M218_ZN630_HUMAN:290:566_5v3m_C_1	ModCRE	Homology model	GGACATTTTTCCGACCCCCACCCCCT	Region 290-566 · 1 3D model		Open · Scan
TFS_sp_Q2M218_ZN630_HUMAN:316:593_5wjq_D_1	ModCRE	Homology model	GCGATAAAACCCGCCCTCCCACCGTCCC	Region 316-593 · 1 3D model		Open · Scan
TFS_sp_Q2M218_ZN630_HUMAN:384:537_2i13_A_1	ModCRE	Homology model	CCAAGCTAGGAGGCTCTATGT	Region 384-537 · 1 3D model		Open · Scan
TFS_sp_Q2M218_ZN630_HUMAN:456:566_5ei9_E_1	ModCRE	Homology model	GCGGGGAGGGGGGCGGC	Region 456-566 · 1 3D model		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 657 aa

173-289

290-593

Region 173-289 5 PWM

Residues

117 aa

Domains

PF00096 · Zinc finger, C2H2 type

3D models

5 active PDBs

Templates

2I13, 5EH2, 5V3J, 5V3M, 5WJQ

Sources

Predicted = Low

Scan this region Show models

Region 290-593 5 PWM

Residues

304 aa

Domains

PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type

3D models

7 active PDBs · 6 summary rows

Templates

1LLM, 2I13, 5EI9, 5V3J, 5V3M, 5WJQ, 7W1M

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

12 active PDB models 6 summary rows

Region 173-2895 models

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	TFS_sp_Q2M218_ZN630_HUMAN:173:289_5v3j_E_1	5v3j	173-289	View model · PDB
Predicted = Low	TFS_sp_Q2M218_ZN630_HUMAN:173:289_5v3m_C_1	5v3m	173-289	View model · PDB
Predicted = Low	TFS_sp_Q2M218_ZN630_HUMAN:173:289_5wjq_D_1	5wjq	173-289	View model · PDB
Predicted = Low	TFS_sp_Q2M218_ZN630_HUMAN:174:289_2i13_A_1	2i13	174-289	View model · PDB
Predicted = Low	TFS_sp_Q2M218_ZN630_HUMAN:229:289_5eh2_F_1	5eh2	229-289	View model · PDB

Region 290-5937 models · 6 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_sp_Q2M218_ZN630_HUMAN:457:508_1llm_D_1	1llm	457-508	View model · PDB
Predicted = Low	TFS_sp_Q2M218_ZN630_HUMAN:290:566_5v3j_E_1	5v3j	290-566	View model · PDB
Predicted = Low	TFS_sp_Q2M218_ZN630_HUMAN:290:566_5v3m_C_1	5v3m	290-566	View model · PDB
Predicted = Low	TFS_sp_Q2M218_ZN630_HUMAN:291:589_7w1m_H_1	7w1m	291-589	View model · PDB
Predicted = Low	TFS_sp_Q2M218_ZN630_HUMAN:316:593_5wjq_D_1	5wjq	316-593	View model · PDB
Predicted = Low	TFS_sp_Q2M218_ZN630_HUMAN:384:537_2i13_A_1	2i13	384-537	View model · PDB
Predicted = Low	TFS_sp_Q2M218_ZN630_HUMAN:456:566_5ei9_E_1	5ei9	456-566	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
4	2i13	261:596	384	537	P:A · DNA:C,D	63.0% / 73.4%	100	View · PDB TFS_sp_Q2M218_ZN630_HUMAN:384:537_2i13_A_1
1	5wjq	261:596	316	593	P:D · DNA:A,B	53.2% / 69.1%	98	View · PDB TFS_sp_Q2M218_ZN630_HUMAN:316:593_5wjq_D_1
2	5v3m	261:596	290	566	P:C · DNA:A,B	52.3% / 68.6%	100	View · PDB TFS_sp_Q2M218_ZN630_HUMAN:290:566_5v3m_C_1
3	5v3j	261:596	290	566	P:E · DNA:A,B	52.3% / 68.6%	100	View · PDB TFS_sp_Q2M218_ZN630_HUMAN:290:566_5v3j_E_1
1	1llm	261:596	457,457	508,508	P:C,D · DNA:A,B	44.2% / 59.6%	59,61	View · PDB DIMER_sp_Q2M218_ZN630_HUMAN:457:508_1llm_D_1
5	7w1m	261:596	291	589	P:H · DNA:F,G	35.1% / 51.0%	92	View · PDB TFS_sp_Q2M218_ZN630_HUMAN:291:589_7w1m_H_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
7-48	PF01352	KRAB box	No overlap with loaded model regions
264-285	PF00096	Zinc finger, C2H2 type	overlaps 173-289
291-313	PF00096	Zinc finger, C2H2 type	overlaps 290-593
347-369	PF00096	Zinc finger, C2H2 type	overlaps 290-593
403-425	PF00096	Zinc finger, C2H2 type	overlaps 290-593
431-453	PF00096	Zinc finger, C2H2 type	overlaps 290-593
459-481	PF00096	Zinc finger, C2H2 type	overlaps 290-593
487-509	PF00096	Zinc finger, C2H2 type	overlaps 290-593
515-537	PF00096	Zinc finger, C2H2 type	overlaps 290-593
543-565	PF00096	Zinc finger, C2H2 type	overlaps 290-593
571-593	PF00096	Zinc finger, C2H2 type	overlaps 290-593