Transcription factor

Q59EZ8

ZNF74 protein variant

Homo sapiens (Human) · Unreviewed (UniProtKB/TrEMBL) · 606 aa

76 Generated PWM 6 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)72

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
M00944_2.00	NN 70-40%	CisBP	TCGCTATAA	63.5% identity		Open · Scan
M00939_2.00	NN 70-40%	CisBP	CCACCTCA	62.3% identity		Open · Scan
M00955_2.00	NN 70-40%	CisBP	ACGTCCTCT	62.3% identity		Open · Scan
M00953_2.00	NN 70-40%	CisBP	ATCTATAT	61.1% identity		Open · Scan
M08985_2.00	NN 70-40%	CisBP	TGAGGACCTACTGTGTGCC	60.3% identity		Open · Scan
M00943_2.00	NN 70-40%	CisBP	CCCGCTGC	58.8% identity		Open · Scan
M00952_2.00	NN 70-40%	CisBP	GGATGCTC	58.8% identity		Open · Scan
M00958_2.00	NN 70-40%	CisBP	CGGCATCCC	58.8% identity		Open · Scan
M08375_2.00	NN 70-40%	CisBP	TTCCCCATTGGCTACTGCACCGGTCCT	58.7% identity		Open · Scan
M08267_2.00	NN 70-40%	CisBP	CAGTTTCATTTTCC	58.6% identity		Open · Scan
M04650_2.00	NN 70-40%	CisBP	GCATAACTGCCCCGCTGCC	58.4% identity		Open · Scan
M08325_2.00	NN 70-40%	CisBP	TTTTTTTTT	58.4% identity		Open · Scan
M00948_2.00	NN 70-40%	CisBP	GCAGCACC	57.6% identity		Open · Scan
M00950_2.00	NN 70-40%	CisBP	GCAGCCCA	57.6% identity		Open · Scan
M00959_2.00	NN 70-40%	CisBP	GCCCTCCC	57.6% identity		Open · Scan
M00960_2.00	NN 70-40%	CisBP	TGCATCCC	57.6% identity		Open · Scan
M02924_2.00	NN 70-40%	CisBP	AGTGTTAACAGAACACCT	57.6% identity		Open · Scan
M04613_2.00	NN 70-40%	CisBP	CTCATGTGCTAATTACAAA	57.2% identity		Open · Scan
M08245_2.00	NN 70-40%	CisBP	TGGTGCCTTATTCCC	56.5% identity		Open · Scan
M00945_2.00	NN 70-40%	CisBP	CACCGCAC	56.3% identity		Open · Scan
M08334_2.00	NN 70-40%	CisBP	TTTGTTTTTTTCTGATTGCTTTTTACTTAT	56.2% identity		Open · Scan
M08329_2.00	NN 70-40%	CisBP	GCTGCATAGTATTCC	56.1% identity		Open · Scan
M00609_2.00	NN 70-40%	CisBP	GGAAGCCCTA	55.9% identity		Open · Scan
M08252_2.00	NN 70-40%	CisBP	CCGGCTCCAGCACCC	55.7% identity		Open · Scan
M00782_2.00	NN 70-40%	CisBP	AGTGTGCGCTA	55.0% identity		Open · Scan
M08355_2.00	NN 70-40%	CisBP	GCGAACTCCTATTCATCC	55.0% identity		Open · Scan
MA1124.1	NN 70-40%	JASPAR	CATTCATTCATTC	55.0% identity		Open · Scan
M07613_2.00	NN 70-40%	CisBP	TCACTCAGTCATTCA	54.7% identity		Open · Scan
M07753_2.00	NN 70-40%	CisBP	TGCATTCCTTGGCTTGTG	54.1% identity		Open · Scan
M07678_2.00	NN 70-40%	CisBP	CCCGCCCCCTCCTCCCCCTTCCCACCC	54.0% identity		Open · Scan
M07747_2.00	NN 70-40%	CisBP	TGGTCTATAAAGGGCCTGGTT	54.0% identity		Open · Scan
M04515_2.00	NN 70-40%	CisBP	TATGCTATAACAAGCAGCCCC	53.5% identity		Open · Scan
M07581_2.00	NN 70-40%	CisBP	TCCCCTGTGCTTCTCTCCCCT	53.5% identity		Open · Scan
M07656_2.00	NN 70-40%	CisBP	TGTCTAGTAAGTCTA	53.2% identity		Open · Scan
M07754_2.00	NN 70-40%	CisBP	CGCCCCCTCCCT	52.9% identity		Open · Scan
M07638_2.00	NN 70-40%	CisBP	TGCAGCTCCCTGCCC	52.8% identity		Open · Scan
M04465_2.00	NN 70-40%	CisBP	GTGATTCTTATCTTATCCTT	52.6% identity		Open · Scan
M04598_2.00	NN 70-40%	CisBP	CGCTAACTCTCCACA	52.6% identity		Open · Scan
M07657_2.00	NN 70-40%	CisBP	CCCCTGCATGTCCCCATTTTT	52.6% identity		Open · Scan
M08335_2.00	NN 70-40%	CisBP	AGTCGTTGTCTG	52.6% identity		Open · Scan
M07618_2.00	NN 70-40%	CisBP	CCTTTGGTGCTC	52.5% identity		Open · Scan
M04387_2.00	NN 70-40%	CisBP	CGTGCTCCCC	52.2% identity		Open · Scan
M01456_2.00	NN 70-40%	CisBP	GTGATCGGCG	52.1% identity		Open · Scan
M07562_2.00	NN 70-40%	CisBP	GAAAAAAAC	52.1% identity		Open · Scan
M07587_2.00	NN 70-40%	CisBP	CCCCCTCCCCAGTCGAGCCCCCGC	52.1% identity		Open · Scan
M07683_2.00	NN 70-40%	CisBP	GTGGGAAAGCCT	52.1% identity		Open · Scan
MA1601.1	NN 70-40%	JASPAR	ATGTGGGAAA	52.1% identity		Open · Scan
M07610_2.00	NN 70-40%	CisBP	CCTTCTTCCTCCCCCCTGCCCACC	51.9% identity		Open · Scan
M07723_2.00	NN 70-40%	CisBP	CCGCTGCTCCCTGCT	51.9% identity		Open · Scan
M08292_2.00	NN 70-40%	CisBP	TGTATTCCTTGTCATGTGTGG	51.9% identity		Open · Scan
M04621_2.00	NN 70-40%	CisBP	AGCAATTCCGCTCA	51.5% identity		Open · Scan
M03671_2.00	NN 70-40%	CisBP	ATTACCATACAAGTGCAC	51.2% identity		Open · Scan
MA1656.1	NN 70-40%	JASPAR	CCAAGCCCAACCAG	51.2% identity		Open · Scan
M06112_2.00	NN 70-40%	CisBP	CTACTTTCACCGGGG	51.0% identity		Open · Scan
M08314_2.00	NN 70-40%	CisBP	ATTCATCAAGGTCCTCAACAATGG	51.0% identity		Open · Scan
M08901_2.00	NN 70-40%	CisBP	CCAGTTCACACC	51.0% identity		Open · Scan
M01474_2.00	NN 70-40%	CisBP	CGCCGATCAC	50.9% identity		Open · Scan
M08395_2.00	NN 70-40%	CisBP	GCTGCCTACTCTTCC	50.9% identity		Open · Scan
M04611_2.00	NN 70-40%	CisBP	CTTTCGGACAC	50.7% identity		Open · Scan
M07600_2.00	NN 70-40%	CisBP	GCATTAGC	50.7% identity		Open · Scan
M07633_2.00	NN 70-40%	CisBP	CTCTCGTTGTGCCTTTGCCAT	50.7% identity		Open · Scan
M08373_2.00	NN 70-40%	CisBP	CCCCCTGGCTCTTCCTCT	50.6% identity		Open · Scan
M04536_2.00	NN 70-40%	CisBP	ACGTAACCCGATACC	50.5% identity		Open · Scan
M08311_2.00	NN 70-40%	CisBP	CTGGAACAGAAGGGGCGA	50.5% identity		Open · Scan
M07588_2.00	NN 70-40%	CisBP	TCCTTCCCTCTTTCC	50.4% identity		Open · Scan
MA1602.1	NN 70-40%	JASPAR	CGTCTACACGGG	50.4% identity		Open · Scan
M08247_2.00	NN 70-40%	CisBP	AAAAATAACAAACGG	50.3% identity		Open · Scan
MA1154.1	NN 70-40%	JASPAR	CTTTCCCACAACACGAC	50.2% identity		Open · Scan
M07660_2.00	NN 70-40%	CisBP	CCGCGCCTACCTGAGGGCGCGGGCCTGGGG	50.1% identity		Open · Scan
M08255_2.00	NN 70-40%	CisBP	CTCTTCCGGT	50.1% identity		Open · Scan
M00786_2.00	NN 70-40%	CisBP	TATATATAT	50.0% identity		Open · Scan
M07628_2.00	NN 70-40%	CisBP	AGTGGTTCTGCTTCT	50.0% identity		Open · Scan

ModCRE4

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
TFS_tr_Q59EZ8_Q59EZ8_HUMAN:207:485_5wjq_D_1	ModCRE	Homology model	TGGGGGGGCCCCCCCTATCCATTCCCCC	Region 207-485 · 1 3D model		Open · Scan
TFS_tr_Q59EZ8_Q59EZ8_HUMAN:265:541_5v3j_E_1	ModCRE	Homology model	GGTCCCCGTGCGGTGGGACCCGGGTC	Region 265-541 · 1 3D model		Open · Scan
TFS_tr_Q59EZ8_Q59EZ8_HUMAN:265:541_5v3m_C_1	ModCRE	Homology model	CCCCCCGGCCCCCCCCGCCCCCCCCA	Region 265-541 · 1 3D model		Open · Scan
TFS_tr_Q59EZ8_Q59EZ8_HUMAN:359:512_2i13_A_1	ModCRE	Homology model	GCCCACCTAGCTACTCTTCAC	Region 359-512 · 1 3D model		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 606 aa

207-541

Region 207-541 4 PWM

Residues

335 aa

Domains

PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type

3D models

6 active PDBs · 6 summary rows

Templates

1LLM, 2I13, 5V3J, 5V3M, 5WJQ, 7W1M

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

6 active PDB models 6 summary rows

Region 207-5416 models · 6 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_tr_Q59EZ8_Q59EZ8_HUMAN:292:343_1llm_D_1	1llm	292-343	View model · PDB
Predicted = Low	TFS_tr_Q59EZ8_Q59EZ8_HUMAN:207:485_5wjq_D_1	5wjq	207-485	View model · PDB
Predicted = Low	TFS_tr_Q59EZ8_Q59EZ8_HUMAN:210:508_7w1m_H_1	7w1m	210-508	View model · PDB
Predicted = Low	TFS_tr_Q59EZ8_Q59EZ8_HUMAN:265:541_5v3j_E_1	5v3j	265-541	View model · PDB
Predicted = Low	TFS_tr_Q59EZ8_Q59EZ8_HUMAN:265:541_5v3m_C_1	5v3m	265-541	View model · PDB
Predicted = Low	TFS_tr_Q59EZ8_Q59EZ8_HUMAN:359:512_2i13_A_1	2i13	359-512	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
4	2i13	207:541	359	512	P:A · DNA:C,D	53.9% / 69.5%	100	View · PDB TFS_tr_Q59EZ8_Q59EZ8_HUMAN:359:512_2i13_A_1
3	5wjq	207:541	207	485	P:D · DNA:A,B	51.6% / 66.7%	99	View · PDB TFS_tr_Q59EZ8_Q59EZ8_HUMAN:207:485_5wjq_D_1
1	5v3m	207:541	265	541	P:C · DNA:A,B	50.5% / 71.1%	100	View · PDB TFS_tr_Q59EZ8_Q59EZ8_HUMAN:265:541_5v3m_C_1
2	5v3j	207:541	265	541	P:E · DNA:A,B	50.5% / 71.1%	100	View · PDB TFS_tr_Q59EZ8_Q59EZ8_HUMAN:265:541_5v3j_E_1
1	1llm	207:541	292,292	343,343	P:C,D · DNA:A,B	42.3% / 59.6%	59,61	View · PDB DIMER_tr_Q59EZ8_Q59EZ8_HUMAN:292:343_1llm_D_1
5	7w1m	207:541	210	508	P:H · DNA:F,G	36.0% / 51.3%	92	View · PDB TFS_tr_Q59EZ8_Q59EZ8_HUMAN:210:508_7w1m_H_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
4-45	PF01352	KRAB box	No overlap with loaded model regions
210-232	PF00096	Zinc finger, C2H2 type	overlaps 207-541
238-260	PF00096	Zinc finger, C2H2 type	overlaps 207-541
266-288	PF00096	Zinc finger, C2H2 type	overlaps 207-541
322-344	PF00096	Zinc finger, C2H2 type	overlaps 207-541
378-400	PF00096	Zinc finger, C2H2 type	overlaps 207-541
434-456	PF00096	Zinc finger, C2H2 type	overlaps 207-541
490-512	PF00096	Zinc finger, C2H2 type	overlaps 207-541
518-540	PF00096	Zinc finger, C2H2 type	overlaps 207-541