ModCRE DB

Transcription factor

Q5TGS1 - HES3

Transcription factor HES-3 (Class B basic helix-loop-helix protein 43) (bHLHb43) (Hairy and enhancer of split 3)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 186 aa

12 Generated PWM 15 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)4
MotifPredictionSourceDNA bindingSupportLogoActions
M05959_2.00 NN 70-40% CisBP GGCACGTGCCA 58.8% identity Open · Scan
M01747_2.00 NN 70-40% CisBP GGCACGTGCC 56.5% identity Open · Scan
M09656_2.00 NN 70-40% CisBP GGCACGCGCC 54.9% identity Open · Scan
M03596_2.00 NN 70-40% CisBP TTGGCACGTGCCAT 50.0% identity Open · Scan
ModCRE8
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_sp_Q5TGS1_HES3_HUMAN:1:52_4h10_A_1 ModCRE Homology model GGGCCACGTGTGGT Region 1-52 · 1 3D model Open · Scan
DIMER_sp_Q5TGS1_HES3_HUMAN:32:56_1am9_B_1 ModCRE Homology model CCAGGGTGGCGTGGCCGCGCGGT Region 32-56 · 1 3D model Open · Scan
DIMER_sp_Q5TGS1_HES3_HUMAN:32:56_1am9_D_1 ModCRE Homology model GGCTGTGCGCACACCCTGCCAC Region 32-56 · 1 3D model Open · Scan
DIMER_sp_Q5TGS1_HES3_HUMAN:39:73_1a6y_A_1 ModCRE Homology model TACAGGGGGGGGAGAGAG Region 39-73 · 1 3D model Open · Scan
DIMER_sp_Q5TGS1_HES3_HUMAN:39:73_1ga5_B_1 ModCRE Homology model TAACAGGGGGGCTGAGAG Region 39-73 · 1 3D model Open · Scan
TFS_sp_Q5TGS1_HES3_HUMAN:1:52_4h10_A_1 ModCRE Homology model TGGCCACGTGTGGG Region 1-52 · 1 3D model Open · Scan
TFS_sp_Q5TGS1_HES3_HUMAN:2:47_8osl_O_1 ModCRE Homology model GCCCGTGGCCCAGAGT Region 2-47 · 1 3D model Open · Scan
TFS_sp_Q5TGS1_HES3_HUMAN:3:48_5nj8_A_1 ModCRE Homology model GTGTCACCCCCC Region 3-48 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 186 aa
1-73

Region 1-73 8 PWM

Residues
73 aa
Domains
PF00010 · Helix-loop-helix DNA-binding domain
3D models
15 active PDBs · 10 summary rows
Templates
1A6Y, 1AM9, 1GA5, 4H10, 5NJ8, 8OSJ, 8OSK, 8OSL
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
15 active PDB models 10 summary rows
Region 1-7315 models · 10 summary rows
Actions
Predicted = Low DIMER_sp_Q5TGS1_HES3_HUMAN:1:46_8osj_N_1 8osj 1-46 View model · PDB
Predicted = Low DIMER_sp_Q5TGS1_HES3_HUMAN:1:52_4h10_A_1 4h10 1-52 View model · PDB
Predicted = Low DIMER_sp_Q5TGS1_HES3_HUMAN:2:47_8osk_M_1 8osk 2-47 View model · PDB
Predicted = Low DIMER_sp_Q5TGS1_HES3_HUMAN:2:47_8osl_M_1 8osl 2-47 View model · PDB
Predicted = Low DIMER_sp_Q5TGS1_HES3_HUMAN:2:47_8osl_O_1 8osl 2-47 View model · PDB
Predicted = Low DIMER_sp_Q5TGS1_HES3_HUMAN:32:56_1am9_B_1 1am9 32-56 View model · PDB
Predicted = Low DIMER_sp_Q5TGS1_HES3_HUMAN:32:56_1am9_D_1 1am9 32-56 View model · PDB
Predicted = Low DIMER_sp_Q5TGS1_HES3_HUMAN:39:73_1a6y_A_1 1a6y 39-73 View model · PDB
Predicted = Low DIMER_sp_Q5TGS1_HES3_HUMAN:39:73_1ga5_B_1 1ga5 39-73 View model · PDB
Predicted = Low TFS_sp_Q5TGS1_HES3_HUMAN:1:46_8osj_N_1 8osj 1-46 View model · PDB
Predicted = Low TFS_sp_Q5TGS1_HES3_HUMAN:1:52_4h10_A_1 4h10 1-52 View model · PDB
Predicted = Low TFS_sp_Q5TGS1_HES3_HUMAN:2:47_8osk_M_1 8osk 2-47 View model · PDB
Predicted = Low TFS_sp_Q5TGS1_HES3_HUMAN:2:47_8osl_M_1 8osl 2-47 View model · PDB
Predicted = Low TFS_sp_Q5TGS1_HES3_HUMAN:2:47_8osl_O_1 8osl 2-47 View model · PDB
Predicted = Low TFS_sp_Q5TGS1_HES3_HUMAN:3:48_5nj8_A_1 5nj8 3-48 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
2 8osl 1:52 2,1 47,46 P:O,P · DNA:I,J 34.8% / 65.2% 70,86 View · PDB DIMER_sp_Q5TGS1_HES3_HUMAN:2:47_8osl_O_1
2 8osl 1:52 2,1 47,46 P:O,P · DNA:I,J 34.8% / 65.2% 70,86 View · PDB TFS_sp_Q5TGS1_HES3_HUMAN:2:47_8osl_O_1
4 8osl 1:52 2,1 47,46 P:M,P · DNA:I,J 34.8% / 65.2% 12,86 View · PDB DIMER_sp_Q5TGS1_HES3_HUMAN:2:47_8osl_M_1
4 8osl 1:52 2,1 47,46 P:M,P · DNA:I,J 34.8% / 65.2% 12,86 View · PDB TFS_sp_Q5TGS1_HES3_HUMAN:2:47_8osl_M_1
5 8osk 1:52 2,1 47,46 P:M,N · DNA:I,J 34.8% / 65.2% 12,15 View · PDB DIMER_sp_Q5TGS1_HES3_HUMAN:2:47_8osk_M_1
5 8osk 1:52 2,1 47,46 P:M,N · DNA:I,J 34.8% / 65.2% 12,15 View · PDB TFS_sp_Q5TGS1_HES3_HUMAN:2:47_8osk_M_1
3 8osj 1:52 2,1 47,46 P:M,N · DNA:I,J 32.6% / 65.2% 63,79 View · PDB DIMER_sp_Q5TGS1_HES3_HUMAN:1:46_8osj_N_1
3 8osj 1:52 2,1 47,46 P:M,N · DNA:I,J 32.6% / 65.2% 63,79 View · PDB TFS_sp_Q5TGS1_HES3_HUMAN:1:46_8osj_N_1
1 4h10 1:52 1,2 52,47 P:A,B · DNA:C,D 30.8% / 67.3% 81,63 View · PDB DIMER_sp_Q5TGS1_HES3_HUMAN:1:52_4h10_A_1
1 4h10 1:52 1,2 52,47 P:A,B · DNA:C,D 30.8% / 67.3% 81,63 View · PDB TFS_sp_Q5TGS1_HES3_HUMAN:1:52_4h10_A_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
1-50PF00010Helix-loop-helix DNA-binding domainoverlaps 1-73