Transcription factor

Q6NSZ9 - ZSCAN25

Zinc finger and SCAN domain-containing protein 25 (Zinc finger protein 498)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 544 aa

113 Generated PWM 13 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)100

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
M00952_2.00	NN 70-40%	CisBP	GGATGCTC	67.0% identity		Open · Scan
M00959_2.00	NN 70-40%	CisBP	GCCCTCCC	67.0% identity		Open · Scan
M00960_2.00	NN 70-40%	CisBP	TGCATCCC	65.9% identity		Open · Scan
M00943_2.00	NN 70-40%	CisBP	CCCGCTGC	65.8% identity		Open · Scan
M04611_2.00	NN 70-40%	CisBP	CTTTCGGACAC	65.4% identity		Open · Scan
M00944_2.00	NN 70-40%	CisBP	TCGCTATAA	64.7% identity		Open · Scan
M00948_2.00	NN 70-40%	CisBP	GCAGCACC	64.7% identity		Open · Scan
M00958_2.00	NN 70-40%	CisBP	CGGCATCCC	63.6% identity		Open · Scan
M00769_2.00	NN 70-40%	CisBP	ACTCCCCC	63.3% identity		Open · Scan
M00953_2.00	NN 70-40%	CisBP	ATCTATAT	62.6% identity		Open · Scan
M00950_2.00	NN 70-40%	CisBP	GCAGCCCA	61.4% identity		Open · Scan
M07579_2.00	NN 70-40%	CisBP	CATCTCCAGGA	60.5% identity		Open · Scan
M00939_2.00	NN 70-40%	CisBP	CCACCTCA	59.2% identity		Open · Scan
M08252_2.00	NN 70-40%	CisBP	CCGGCTCCAGCACCC	58.9% identity		Open · Scan
M07635_2.00	NN 70-40%	CisBP	AAGTTTTCTTGTATTATATCT	58.1% identity		Open · Scan
M07700_2.00	NN 70-40%	CisBP	ATGTTGTGAGGAAGCCCA	57.5% identity		Open · Scan
M08267_2.00	NN 70-40%	CisBP	CAGTTTCATTTTCC	57.5% identity		Open · Scan
M08311_2.00	NN 70-40%	CisBP	CTGGAACAGAAGGGGCGA	57.0% identity		Open · Scan
M00955_2.00	NN 70-40%	CisBP	ACGTCCTCT	56.9% identity		Open · Scan
M07777_2.00	NN 70-40%	CisBP	GCCAATTTCCGTGGTGTAAAT	56.9% identity		Open · Scan
M04387_2.00	NN 70-40%	CisBP	CGTGCTCCCC	56.7% identity		Open · Scan
M08917_2.00	NN 70-40%	CisBP	GCTGAGCCATGTGGGGTGCT	56.7% identity		Open · Scan
M07610_2.00	NN 70-40%	CisBP	CCTTCTTCCTCCCCCCTGCCCACC	56.5% identity		Open · Scan
M08247_2.00	NN 70-40%	CisBP	AAAAATAACAAACGG	56.2% identity		Open · Scan
MA1594.1	NN 70-40%	JASPAR	AGGGGACATCACTACAGATCCCAC	56.2% identity		Open · Scan
M04475_2.00	NN 70-40%	CisBP	GATGCACGTACCGTGCCTCA	56.0% identity		Open · Scan
M08334_2.00	NN 70-40%	CisBP	TTTGTTTTTTTCTGATTGCTTTTTACTTAT	55.8% identity		Open · Scan
M08371_2.00	NN 70-40%	CisBP	CCAGACTTGTCCTCT	55.4% identity		Open · Scan
MA1587.1	NN 70-40%	JASPAR	CCTCGACCTCCTGA	55.3% identity		Open · Scan
M07754_2.00	NN 70-40%	CisBP	CGCCCCCTCCCT	54.9% identity		Open · Scan
M08329_2.00	NN 70-40%	CisBP	GCTGCATAGTATTCC	54.9% identity		Open · Scan
M07764_2.00	NN 70-40%	CisBP	CTGCACTCTCCCCTTCCCCCCCTCCCC	54.7% identity		Open · Scan
M08263_2.00	NN 70-40%	CisBP	ATCTCGGCACTTTGGGAGGCCA	54.5% identity		Open · Scan
M08375_2.00	NN 70-40%	CisBP	TTCCCCATTGGCTACTGCACCGGTCCT	54.5% identity		Open · Scan
M07712_2.00	NN 70-40%	CisBP	ACATTTTTTTAATCTAAAAAAACATTTACA	54.4% identity		Open · Scan
M07613_2.00	NN 70-40%	CisBP	TCACTCAGTCATTCA	54.2% identity		Open · Scan
M08279_2.00	NN 70-40%	CisBP	CCTCCCTCC	54.1% identity		Open · Scan
M07753_2.00	NN 70-40%	CisBP	TGCATTCCTTGGCTTGTG	53.9% identity		Open · Scan
M07725_2.00	NN 70-40%	CisBP	AAGCACTGTACT	53.8% identity		Open · Scan
M07581_2.00	NN 70-40%	CisBP	TCCCCTGTGCTTCTCTCCCCT	53.5% identity		Open · Scan
MA1602.1	NN 70-40%	JASPAR	CGTCTACACGGG	53.5% identity		Open · Scan
M07667_2.00	NN 70-40%	CisBP	CCGCACAGGCCCCCGGGCCCC	53.4% identity		Open · Scan
M08395_2.00	NN 70-40%	CisBP	GCTGCCTACTCTTCC	53.4% identity		Open · Scan
M08325_2.00	NN 70-40%	CisBP	TTTTTTTTT	53.3% identity		Open · Scan
M00782_2.00	NN 70-40%	CisBP	AGTGTGCGCTA	53.1% identity		Open · Scan
M07618_2.00	NN 70-40%	CisBP	CCTTTGGTGCTC	53.1% identity		Open · Scan
M08355_2.00	NN 70-40%	CisBP	GCGAACTCCTATTCATCC	53.1% identity		Open · Scan
M02913_2.00	NN 70-40%	CisBP	TTCGTGGCATTTTTCTA	52.8% identity		Open · Scan
M07660_2.00	NN 70-40%	CisBP	CCGCGCCTACCTGAGGGCGCGGGCCTGGGG	52.8% identity		Open · Scan
M08274_2.00	NN 70-40%	CisBP	TTACTTGCAGCCCAACGCATTCCTAAC	52.8% identity		Open · Scan
M08934_2.00	NN 70-40%	CisBP	GCTGTACCTGCTTATTAGGC	52.8% identity		Open · Scan
MA1154.1	NN 70-40%	JASPAR	CTTTCCCACAACACGAC	52.7% identity		Open · Scan
M00149_2.00	NN 70-40%	CisBP	CGTACGCC	52.6% identity		Open · Scan
M07593_2.00	NN 70-40%	CisBP	AGATGAAGTCACCCCTCTTAC	52.6% identity		Open · Scan
M08255_2.00	NN 70-40%	CisBP	CTCTTCCGGT	52.6% identity		Open · Scan
M08949_2.00	NN 70-40%	CisBP	TTCTATTTCTTCTTGTGTCA	52.6% identity		Open · Scan
M07578_2.00	NN 70-40%	CisBP	CAACTCTCC	52.5% identity		Open · Scan
M08358_2.00	NN 70-40%	CisBP	CCCTCCCCCTCC	52.4% identity		Open · Scan
M07598_2.00	NN 70-40%	CisBP	CTGACAATACCAAGTGTTGAC	52.3% identity		Open · Scan
M07678_2.00	NN 70-40%	CisBP	CCCGCCCCCTCCTCCCCCTTCCCACCC	52.3% identity		Open · Scan
M00945_2.00	NN 70-40%	CisBP	CACCGCAC	52.2% identity		Open · Scan
M08386_2.00	NN 70-40%	CisBP	GCCTTAAAAGCTCAGCAC	52.2% identity		Open · Scan
M04430_2.00	NN 70-40%	CisBP	GACCACGCCCA	51.9% identity		Open · Scan
MA0742.1	NN 70-40%	JASPAR	GACCACGCCCTTATT	51.9% identity		Open · Scan
M08392_2.00	NN 70-40%	CisBP	CTTCACCTGCTGAGG	51.8% identity		Open · Scan
M08860_2.00	NN 70-40%	CisBP	TCTTATAAGGGCACTAATCCCATT	51.8% identity		Open · Scan
M07746_2.00	NN 70-40%	CisBP	CAGCTGGCGCCCAACATGGGTCCC	51.7% identity		Open · Scan
M08373_2.00	NN 70-40%	CisBP	CCCCCTGGCTCTTCCTCT	51.7% identity		Open · Scan
M07701_2.00	NN 70-40%	CisBP	CCTGGGCTAGGCCCTGGC	51.5% identity		Open · Scan
M08357_2.00	NN 70-40%	CisBP	GAGCCTGCTACTGAGCCTGGG	51.5% identity		Open · Scan
M04598_2.00	NN 70-40%	CisBP	CGCTAACTCTCCACA	51.3% identity		Open · Scan
M08291_2.00	NN 70-40%	CisBP	AATCCAGCCCTAGACTCTCCC	51.3% identity		Open · Scan
M07662_2.00	NN 70-40%	CisBP	CCTGTGTCCTCCCTGGTCCCC	51.2% identity		Open · Scan
M00142_2.00	NN 70-40%	CisBP	GTGCTCCT	51.1% identity		Open · Scan
M07588_2.00	NN 70-40%	CisBP	TCCTTCCCTCTTTCC	51.0% identity		Open · Scan
MA1597.1	NN 70-40%	JASPAR	CCCAGGGAAGCCATTTC	50.9% identity		Open · Scan
M00146_2.00	NN 70-40%	CisBP	TGTTCTAGAT	50.8% identity		Open · Scan
M01442_2.00	NN 70-40%	CisBP	ACCCCACATT	50.8% identity		Open · Scan
MA1649.1	NN 70-40%	JASPAR	ATCTGGAACCC	50.8% identity		Open · Scan
M04621_2.00	NN 70-40%	CisBP	AGCAATTCCGCTCA	50.7% identity		Open · Scan
M07729_2.00	NN 70-40%	CisBP	CCAGACTGCCTGCCAAAACCCCCT	50.7% identity		Open · Scan
M07762_2.00	NN 70-40%	CisBP	GCCGCGCACAGGCTTCTAGCC	50.7% identity		Open · Scan
M08256_2.00	NN 70-40%	CisBP	GTGCCTT	50.7% identity		Open · Scan
M08342_2.00	NN 70-40%	CisBP	GCTCTGCCTCCCTCT	50.7% identity		Open · Scan
MA1589.1	NN 70-40%	JASPAR	TAGGAGTGGAATTGCTGGGTC	50.7% identity		Open · Scan
M00779_2.00	NN 70-40%	CisBP	GCCACGCCCA	50.6% identity		Open · Scan
M07633_2.00	NN 70-40%	CisBP	CTCTCGTTGTGCCTTTGCCAT	50.6% identity		Open · Scan
M08867_2.00	NN 70-40%	CisBP	CACCCCCTG	50.6% identity		Open · Scan
M04590_2.00	NN 70-40%	CisBP	TGCGCTAACCATTGC	50.5% identity		Open · Scan
M07645_2.00	NN 70-40%	CisBP	CTCCTT	50.4% identity		Open · Scan
M07600_2.00	NN 70-40%	CisBP	GCATTAGC	50.2% identity		Open · Scan
M07646_2.00	NN 70-40%	CisBP	CTTTTTTTT	50.2% identity		Open · Scan
M08245_2.00	NN 70-40%	CisBP	TGGTGCCTTATTCCC	50.2% identity		Open · Scan
M00019_2.00	NN 70-40%	CisBP	ACCCCTAATT	50.0% identity		Open · Scan
M01531_2.00	NN 70-40%	CisBP	CCCCCCCTAAAT	50.0% identity		Open · Scan
M04505_2.00	NN 70-40%	CisBP	AGCTTTTCCCACAC	50.0% identity		Open · Scan
M04536_2.00	NN 70-40%	CisBP	ACGTAACCCGATACC	50.0% identity		Open · Scan
M08292_2.00	NN 70-40%	CisBP	TGTATTCCTTGTCATGTGTGG	50.0% identity		Open · Scan
M08525_2.00	NN 70-40%	CisBP	CCCCGCA	50.0% identity		Open · Scan
M08540_2.00	NN 70-40%	CisBP	CCCCT	50.0% identity		Open · Scan

ModCRE13

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
DIMER_sp_Q6NSZ9_ZSC25_HUMAN:382:419_2wty_B_1	ModCRE	Homology model	CGTTGCTGAGTCAGCACCG	Region 382-419 · 1 3D model		Open · Scan
DIMER_sp_Q6NSZ9_ZSC25_HUMAN:382:419_4auw_A_1	ModCRE	Homology model	CGGTGCCGAGCTCAGAAGGG	Region 382-419 · 1 3D model		Open · Scan
DIMER_sp_Q6NSZ9_ZSC25_HUMAN:484:537_1llm_D_1	ModCRE	Homology model	GCCCGCGGCGGA	Region 484-537 · 1 3D model		Open · Scan
TFS_sp_Q6NSZ9_ZSC25_HUMAN:334:382_2i13_A_1	ModCRE	Homology model	CCCCGGGTGGCG	Region 334-382 · 1 3D model		Open · Scan
TFS_sp_Q6NSZ9_ZSC25_HUMAN:346:383_5egb_A_1	ModCRE	Homology model	AGCGAAAGGGG	Region 346-383 · 1 3D model		Open · Scan
TFS_sp_Q6NSZ9_ZSC25_HUMAN:346:383_5ei9_E_1	ModCRE	Homology model	CACGGGGCC	Region 346-383 · 1 3D model		Open · Scan
TFS_sp_Q6NSZ9_ZSC25_HUMAN:346:541_5v3j_E_1	ModCRE	Homology model	CCTCCGGGCGACCCCCCTCCGGG	Region 346-541 · 1 3D model		Open · Scan
TFS_sp_Q6NSZ9_ZSC25_HUMAN:346:541_5v3m_C_1	ModCRE	Homology model	GGCCCCGGGCCCCCCCCCCGCCGG	Region 346-541 · 1 3D model		Open · Scan
TFS_sp_Q6NSZ9_ZSC25_HUMAN:346:541_5wjq_D_1	ModCRE	Homology model	CCCCCCCGCCCCCCCCCCGGGAGG	Region 346-541 · 1 3D model		Open · Scan
TFS_sp_Q6NSZ9_ZSC25_HUMAN:347:382_5wjq_D_1	ModCRE	Homology model	GGGGGGTCAACC	Region 347-382 · 1 3D model		Open · Scan
TFS_sp_Q6NSZ9_ZSC25_HUMAN:347:383_5eh2_F_1	ModCRE	Homology model	ATCCGAGGGGA	Region 347-383 · 1 3D model		Open · Scan
TFS_sp_Q6NSZ9_ZSC25_HUMAN:384:535_2i13_A_1	ModCRE	Homology model	ACGAACTAGAGGGTATTGGCT	Region 384-535 · 1 3D model		Open · Scan
TFS_sp_Q6NSZ9_ZSC25_HUMAN:400:509_5ei9_E_1	ModCRE	Homology model	CCCCCCCCCCCCGGCGG	Region 400-509 · 1 3D model		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 544 aa

334-541

Region 334-541 13 PWM

Residues

208 aa

Domains

PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type

3D models

13 active PDBs · 8 summary rows

Templates

1LLM, 2I13, 2WTY, 4AUW, 5EGB, 5EH2, 5EI9, 5V3J, ...

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

13 active PDB models 8 summary rows

Region 334-54113 models · 8 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_sp_Q6NSZ9_ZSC25_HUMAN:382:419_2wty_B_1	2wty	382-419	View model · PDB
Predicted = Low	DIMER_sp_Q6NSZ9_ZSC25_HUMAN:382:419_4auw_A_1	4auw	382-419	View model · PDB
Predicted = Low	DIMER_sp_Q6NSZ9_ZSC25_HUMAN:484:537_1llm_D_1	1llm	484-537	View model · PDB
Predicted = Low	TFS_sp_Q6NSZ9_ZSC25_HUMAN:334:382_2i13_A_1	2i13	334-382	View model · PDB
Predicted = Low	TFS_sp_Q6NSZ9_ZSC25_HUMAN:346:383_5egb_A_1	5egb	346-383	View model · PDB
Predicted = Low	TFS_sp_Q6NSZ9_ZSC25_HUMAN:346:383_5ei9_E_1	5ei9	346-383	View model · PDB
Predicted = Low	TFS_sp_Q6NSZ9_ZSC25_HUMAN:346:541_5v3j_E_1	5v3j	346-541	View model · PDB
Predicted = Low	TFS_sp_Q6NSZ9_ZSC25_HUMAN:346:541_5v3m_C_1	5v3m	346-541	View model · PDB
Predicted = Low	TFS_sp_Q6NSZ9_ZSC25_HUMAN:346:541_5wjq_D_1	5wjq	346-541	View model · PDB
Predicted = Low	TFS_sp_Q6NSZ9_ZSC25_HUMAN:347:382_5wjq_D_1	5wjq	347-382	View model · PDB
Predicted = Low	TFS_sp_Q6NSZ9_ZSC25_HUMAN:347:383_5eh2_F_1	5eh2	347-383	View model · PDB
Predicted = Low	TFS_sp_Q6NSZ9_ZSC25_HUMAN:384:535_2i13_A_1	2i13	384-535	View model · PDB
Predicted = Low	TFS_sp_Q6NSZ9_ZSC25_HUMAN:400:509_5ei9_E_1	5ei9	400-509	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
1	2i13	338:541	384	535	P:A · DNA:C,D	60.8% / 75.2%	98	View · PDB TFS_sp_Q6NSZ9_ZSC25_HUMAN:384:535_2i13_A_1
5	5ei9	338:541	400	509	P:E · DNA:A,B	56.8% / 70.3%	99	View · PDB TFS_sp_Q6NSZ9_ZSC25_HUMAN:400:509_5ei9_E_1
2	5v3m	338:541	346	541	P:C · DNA:A,B	49.0% / 64.1%	70	View · PDB TFS_sp_Q6NSZ9_ZSC25_HUMAN:346:541_5v3m_C_1
3	5v3j	338:541	346	541	P:E · DNA:A,B	49.0% / 64.1%	70	View · PDB TFS_sp_Q6NSZ9_ZSC25_HUMAN:346:541_5v3j_E_1
4	5wjq	338:541	346	541	P:D · DNA:A,B	49.0% / 63.6%	69	View · PDB TFS_sp_Q6NSZ9_ZSC25_HUMAN:346:541_5wjq_D_1
1	1llm	338:541	484,484	537,537	P:C,D · DNA:A,B	44.4% / 61.1%	62,63	View · PDB DIMER_sp_Q6NSZ9_ZSC25_HUMAN:484:537_1llm_D_1
2	2wty	338:541	382,382	419,419	P:A,B · DNA:C,D	41.0% / 56.4%	40,39	View · PDB DIMER_sp_Q6NSZ9_ZSC25_HUMAN:382:419_2wty_B_1
3	4auw	338:541	382,382	419,419	P:A,B · DNA:C,D	41.0% / 56.4%	43,44	View · PDB DIMER_sp_Q6NSZ9_ZSC25_HUMAN:382:419_4auw_A_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
38-124	PF02023	SCAN domain	No overlap with loaded model regions
348-370	PF00096	Zinc finger, C2H2 type	overlaps 334-541
377-397	PF00096	Zinc finger, C2H2 type	overlaps 334-541
403-425	PF00096	Zinc finger, C2H2 type	overlaps 334-541
431-453	PF00096	Zinc finger, C2H2 type	overlaps 334-541
462-480	PF00096	Zinc finger, C2H2 type	overlaps 334-541
488-508	PF00096	Zinc finger, C2H2 type	overlaps 334-541
514-537	PF00096	Zinc finger, C2H2 type	overlaps 334-541