ModCRE DB

Transcription factor

Q6XD76 - ASCL4

Achaete-scute homolog 4 (ASH-4) (hASH4) (Achaete-scute-like protein 4) (Class A basic helix-loop-helix protein 44) (bHLHa44)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 172 aa

23 Generated PWM 13 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)12
MotifPredictionSourceDNA bindingSupportLogoActions
MA0816.1 NN 70-40% JASPAR AGCAGCTGCT 60.3% identity Open · Scan
MA1100.1 NN 70-40% JASPAR GCAGCAGCTGGCG 57.6% identity Open · Scan
MA0607.1 NN 70-40% JASPAR CCATATGT 53.1% identity Open · Scan
MA1472.1 NN 70-40% JASPAR AACAGCTGTT 53.1% identity Open · Scan
M00756_2.00 NN 70-40% CisBP CGCAGCTGTG 51.0% identity Open · Scan
MA0048.1 NN 70-40% JASPAR GCGCAGCTGCGT 51.0% identity Open · Scan
MA1529.1 NN 70-40% JASPAR GGGCCGCAGCTGCGTCCC 51.0% identity Open · Scan
M04210_2.00 NN 70-40% CisBP AGCAGCTGCC 50.7% identity Open · Scan
M04156_2.00 NN 70-40% CisBP AACAGCTGACGC 50.0% identity Open · Scan
M05965_2.00 NN 70-40% CisBP AAAAACACCTGCGCC 50.0% identity Open · Scan
MA1485.1 NN 70-40% JASPAR GCAACAGCTGTTAC 50.0% identity Open · Scan
MA1618.1 NN 70-40% JASPAR AAACAGATGTTTA 50.0% identity Open · Scan
ModCRE11
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_sp_Q6XD76_ASCL4_HUMAN:105:125_1am9_B_1 ModCRE Homology model CCACGGCGACCCGCGGGGGTGTGC Region 105-125 · 1 3D model Open · Scan
DIMER_sp_Q6XD76_ASCL4_HUMAN:105:125_1am9_D_1 ModCRE Homology model CGGGGCCCCCGGGGGTCGCGTTG Region 105-125 · 1 3D model Open · Scan
DIMER_sp_Q6XD76_ASCL4_HUMAN:78:131_2ypa_A_1 ModCRE Homology model ACCACGTGGGG Region 78-131 · 1 3D model Open · Scan
DIMER_sp_Q6XD76_ASCL4_HUMAN:78:131_2ypb_A_1 ModCRE Homology model CCCAGCTGGGC Region 78-131 · 1 3D model Open · Scan
DIMER_sp_Q6XD76_ASCL4_HUMAN:80:128_1mdy_B_1 ModCRE Homology model CACACAGCTGTGCA Region 80-128 · 1 3D model Open · Scan
TFS_sp_Q6XD76_ASCL4_HUMAN:76:128_2ql2_B_1 ModCRE Homology model GGGCCCAGCTGGGGGC Region 76-128 · 1 3D model Open · Scan
TFS_sp_Q6XD76_ASCL4_HUMAN:78:131_2ypa_A_1 ModCRE Homology model ACCACGTGGGG Region 78-131 · 1 3D model Open · Scan
TFS_sp_Q6XD76_ASCL4_HUMAN:78:131_2ypb_A_1 ModCRE Homology model CCCAGCTGGGC Region 78-131 · 1 3D model Open · Scan
TFS_sp_Q6XD76_ASCL4_HUMAN:80:127_7z5k_B_1 ModCRE Homology model ATTACTCAGCTGCTGGGG Region 80-127 · 1 3D model Open · Scan
TFS_sp_Q6XD76_ASCL4_HUMAN:80:128_1mdy_A_1 ModCRE Homology model CCAACAGCTGTGCA Region 80-128 · 1 3D model Open · Scan
TFS_sp_Q6XD76_ASCL4_HUMAN:80:128_1mdy_B_1 ModCRE Homology model GACACAGCTGTGCA Region 80-128 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 172 aa
76-131

Region 76-131 11 PWM

Residues
56 aa
Domains
PF00010 · Helix-loop-helix DNA-binding domain
3D models
13 active PDBs · 10 summary rows
Templates
1AM9, 1MDY, 2QL2, 2YPA, 2YPB, 7Z5I, 7Z5K
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
13 active PDB models 10 summary rows
Region 76-13113 models · 10 summary rows
Actions
Predicted = Low DIMER_sp_Q6XD76_ASCL4_HUMAN:105:125_1am9_B_1 1am9 105-125 View model · PDB
Predicted = Low DIMER_sp_Q6XD76_ASCL4_HUMAN:105:125_1am9_D_1 1am9 105-125 View model · PDB
Predicted = Low DIMER_sp_Q6XD76_ASCL4_HUMAN:78:131_2ypa_A_1 2ypa 78-131 View model · PDB
Predicted = Low DIMER_sp_Q6XD76_ASCL4_HUMAN:78:131_2ypb_A_1 2ypb 78-131 View model · PDB
Predicted = Low DIMER_sp_Q6XD76_ASCL4_HUMAN:80:126_7z5i_B_1 7z5i 80-126 View model · PDB
Predicted = Low DIMER_sp_Q6XD76_ASCL4_HUMAN:80:127_7z5k_B_1 7z5k 80-127 View model · PDB
Predicted = Low DIMER_sp_Q6XD76_ASCL4_HUMAN:80:128_1mdy_B_1 1mdy 80-128 View model · PDB
Predicted = Low TFS_sp_Q6XD76_ASCL4_HUMAN:76:128_2ql2_B_1 2ql2 76-128 View model · PDB
Predicted = Low TFS_sp_Q6XD76_ASCL4_HUMAN:78:131_2ypa_A_1 2ypa 78-131 View model · PDB
Predicted = Low TFS_sp_Q6XD76_ASCL4_HUMAN:78:131_2ypb_A_1 2ypb 78-131 View model · PDB
Predicted = Low TFS_sp_Q6XD76_ASCL4_HUMAN:80:127_7z5k_B_1 7z5k 80-127 View model · PDB
Predicted = Low TFS_sp_Q6XD76_ASCL4_HUMAN:80:128_1mdy_A_1 1mdy 80-128 View model · PDB
Predicted = Low TFS_sp_Q6XD76_ASCL4_HUMAN:80:128_1mdy_B_1 1mdy 80-128 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
1 2ypb 75:131 78,78 131,126 P:A,B · DNA:E,F 48.1% / 59.3% 80,66 View · PDB DIMER_sp_Q6XD76_ASCL4_HUMAN:78:131_2ypb_A_1
1 2ypb 75:131 78,78 131,126 P:A,B · DNA:E,F 48.1% / 59.3% 80,66 View · PDB TFS_sp_Q6XD76_ASCL4_HUMAN:78:131_2ypb_A_1
2 2ypa 75:131 78,78 131,126 P:A,B · DNA:E,F 48.1% / 59.3% 80,67 View · PDB DIMER_sp_Q6XD76_ASCL4_HUMAN:78:131_2ypa_A_1
2 2ypa 75:131 78,78 131,126 P:A,B · DNA:E,F 48.1% / 59.3% 80,67 View · PDB TFS_sp_Q6XD76_ASCL4_HUMAN:78:131_2ypa_A_1
3 1mdy 75:131 80,80 128,128 P:A,B · DNA:E,F 46.9% / 61.2% 70,77 View · PDB DIMER_sp_Q6XD76_ASCL4_HUMAN:80:128_1mdy_B_1
4 1mdy 75:131 80,80 128,128 P:A,B · DNA:E,F 46.9% / 61.2% 70,77 View · PDB TFS_sp_Q6XD76_ASCL4_HUMAN:80:128_1mdy_A_1
4 7z5k 75:131 80,80 126,127 P:A,B · DNA:E,F 45.8% / 64.6% 82,83 View · PDB DIMER_sp_Q6XD76_ASCL4_HUMAN:80:127_7z5k_B_1
5 7z5k 75:131 80,80 126,127 P:A,B · DNA:E,F 45.8% / 64.6% 82,83 View · PDB TFS_sp_Q6XD76_ASCL4_HUMAN:80:127_7z5k_B_1
5 7z5i 75:131 80,80 126,126 P:A,B · DNA:E,F 44.7% / 63.8% 82,82 View · PDB DIMER_sp_Q6XD76_ASCL4_HUMAN:80:126_7z5i_B_1
3 2ql2 75:131 76 128 P:B · DNA:E,F 43.4% / 58.5% 89 View · PDB TFS_sp_Q6XD76_ASCL4_HUMAN:76:128_2ql2_B_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
76-125PF00010Helix-loop-helix DNA-binding domainoverlaps 76-131