Transcription factor

Q86UE3 - ZNF546

Zinc finger protein 546 (Zinc finger protein 49)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 836 aa

75 Generated PWM 10 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)70

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
M00959_2.00	NN 70-40%	CisBP	GCCCTCCC	68.2% identity		Open · Scan
M00950_2.00	NN 70-40%	CisBP	GCAGCCCA	67.4% identity		Open · Scan
M00948_2.00	NN 70-40%	CisBP	GCAGCACC	67.0% identity		Open · Scan
M00958_2.00	NN 70-40%	CisBP	CGGCATCCC	67.0% identity		Open · Scan
M00960_2.00	NN 70-40%	CisBP	TGCATCCC	67.0% identity		Open · Scan
M00943_2.00	NN 70-40%	CisBP	CCCGCTGC	65.8% identity		Open · Scan
M00939_2.00	NN 70-40%	CisBP	CCACCTCA	65.0% identity		Open · Scan
M00955_2.00	NN 70-40%	CisBP	ACGTCCTCT	65.0% identity		Open · Scan
M04653_2.00	NN 70-40%	CisBP	GGTACGGTTGTCCATGTTGCAA	64.1% identity		Open · Scan
M00944_2.00	NN 70-40%	CisBP	TCGCTATAA	63.8% identity		Open · Scan
M02924_2.00	NN 70-40%	CisBP	AGTGTTAACAGAACACCT	62.9% identity		Open · Scan
M00952_2.00	NN 70-40%	CisBP	GGATGCTC	62.3% identity		Open · Scan
M00953_2.00	NN 70-40%	CisBP	ATCTATAT	61.4% identity		Open · Scan
M08985_2.00	NN 70-40%	CisBP	TGAGGACCTACTGTGTGCC	61.1% identity		Open · Scan
M08375_2.00	NN 70-40%	CisBP	TTCCCCATTGGCTACTGCACCGGTCCT	60.9% identity		Open · Scan
M04650_2.00	NN 70-40%	CisBP	GCATAACTGCCCCGCTGCC	60.6% identity		Open · Scan
M00782_2.00	NN 70-40%	CisBP	AGTGTGCGCTA	59.0% identity		Open · Scan
M08355_2.00	NN 70-40%	CisBP	GCGAACTCCTATTCATCC	58.4% identity		Open · Scan
M08254_2.00	NN 70-40%	CisBP	CTGCCCTGGGACTTT	58.2% identity		Open · Scan
M07753_2.00	NN 70-40%	CisBP	TGCATTCCTTGGCTTGTG	58.0% identity		Open · Scan
M04611_2.00	NN 70-40%	CisBP	CTTTCGGACAC	57.8% identity		Open · Scan
M04387_2.00	NN 70-40%	CisBP	CGTGCTCCCC	57.4% identity		Open · Scan
M08267_2.00	NN 70-40%	CisBP	CAGTTTCATTTTCC	57.3% identity		Open · Scan
M08295_2.00	NN 70-40%	CisBP	CTGCTGGAATCTCCA	57.1% identity		Open · Scan
M08325_2.00	NN 70-40%	CisBP	TTTTTTTTT	56.6% identity		Open · Scan
M08365_2.00	NN 70-40%	CisBP	GCCAGCAGCCATCAG	56.6% identity		Open · Scan
M07693_2.00	NN 70-40%	CisBP	CTCCTGTGTGTGCCTTGGCTG	56.4% identity		Open · Scan
M08395_2.00	NN 70-40%	CisBP	GCTGCCTACTCTTCC	56.2% identity		Open · Scan
M04598_2.00	NN 70-40%	CisBP	CGCTAACTCTCCACA	55.6% identity		Open · Scan
M08329_2.00	NN 70-40%	CisBP	GCTGCATAGTATTCC	55.6% identity		Open · Scan
M05853_2.00	NN 70-40%	CisBP	CCACCTTTAGCCATATCT	55.4% identity		Open · Scan
M04480_2.00	NN 70-40%	CisBP	ATTGATTACCCACCCTAC	55.1% identity		Open · Scan
M07689_2.00	NN 70-40%	CisBP	ACCCAGGCTCCTTCCATCTTGTGGCTC	54.6% identity		Open · Scan
M04613_2.00	NN 70-40%	CisBP	CTCATGTGCTAATTACAAA	54.4% identity		Open · Scan
M07683_2.00	NN 70-40%	CisBP	GTGGGAAAGCCT	54.4% identity		Open · Scan
MA1124.1	NN 70-40%	JASPAR	CATTCATTCATTC	54.4% identity		Open · Scan
MA1601.1	NN 70-40%	JASPAR	ATGTGGGAAA	54.4% identity		Open · Scan
M01442_2.00	NN 70-40%	CisBP	ACCCCACATT	54.2% identity		Open · Scan
M04621_2.00	NN 70-40%	CisBP	AGCAATTCCGCTCA	54.2% identity		Open · Scan
MA0038.1	NN 70-40%	JASPAR	CAAATCACTG	53.8% identity		Open · Scan
MA0038.2	NN 70-40%	JASPAR	CAAATCACTGCA	53.8% identity		Open · Scan
M04536_2.00	NN 70-40%	CisBP	ACGTAACCCGATACC	53.6% identity		Open · Scan
MA1602.1	NN 70-40%	JASPAR	CGTCTACACGGG	53.5% identity		Open · Scan
M00764_2.00	NN 70-40%	CisBP	GTCTACAC	53.3% identity		Open · Scan
M00786_2.00	NN 70-40%	CisBP	TATATATAT	52.9% identity		Open · Scan
M08334_2.00	NN 70-40%	CisBP	TTTGTTTTTTTCTGATTGCTTTTTACTTAT	52.8% identity		Open · Scan
M07747_2.00	NN 70-40%	CisBP	TGGTCTATAAAGGGCCTGGTT	52.4% identity		Open · Scan
MA1596.1	NN 70-40%	JASPAR	GCCTCAGCCTCCCGAG	52.2% identity		Open · Scan
M07578_2.00	NN 70-40%	CisBP	CAACTCTCC	52.0% identity		Open · Scan
M08274_2.00	NN 70-40%	CisBP	TTACTTGCAGCCCAACGCATTCCTAAC	52.0% identity		Open · Scan
M07600_2.00	NN 70-40%	CisBP	GCATTAGC	51.9% identity		Open · Scan
M07634_2.00	NN 70-40%	CisBP	AAACGTCCACG	51.8% identity		Open · Scan
M07658_2.00	NN 70-40%	CisBP	CCGCCGCAGCCGCCG	51.8% identity		Open · Scan
M07700_2.00	NN 70-40%	CisBP	ATGTTGTGAGGAAGCCCA	51.8% identity		Open · Scan
M00945_2.00	NN 70-40%	CisBP	CACCGCAC	51.7% identity		Open · Scan
M04465_2.00	NN 70-40%	CisBP	GTGATTCTTATCTTATCCTT	51.4% identity		Open · Scan
M07648_2.00	NN 70-40%	CisBP	GCTTGCAAAAAAAATTTAACTCCCAGCTC	51.3% identity		Open · Scan
MA1154.1	NN 70-40%	JASPAR	CTTTCCCACAACACGAC	51.0% identity		Open · Scan
M01474_2.00	NN 70-40%	CisBP	CGCCGATCAC	50.9% identity		Open · Scan
M07657_2.00	NN 70-40%	CisBP	CCCCTGCATGTCCCCATTTTT	50.9% identity		Open · Scan
M07678_2.00	NN 70-40%	CisBP	CCCGCCCCCTCCTCCCCCTTCCCACCC	50.8% identity		Open · Scan
M08309_2.00	NN 70-40%	CisBP	AAAAACCCCCCTGCAGAGCCCAGCCCT	50.8% identity		Open · Scan
M08373_2.00	NN 70-40%	CisBP	CCCCCTGGCTCTTCCTCT	50.7% identity		Open · Scan
M00645_2.00	NN 70-40%	CisBP	CGCCCACGCA	50.6% identity		Open · Scan
M00609_2.00	NN 70-40%	CisBP	GGAAGCCCTA	50.4% identity		Open · Scan
M08859_2.00	NN 70-40%	CisBP	CATTTTTTCCTCCTAGGCCT	50.4% identity		Open · Scan
M07729_2.00	NN 70-40%	CisBP	CCAGACTGCCTGCCAAAACCCCCT	50.2% identity		Open · Scan
M01538_2.00	NN 70-40%	CisBP	GCCCCTGA	50.0% identity		Open · Scan
M07706_2.00	NN 70-40%	CisBP	GTCTTTGAGAGGGCCCAGATGTTGGACTTA	50.0% identity		Open · Scan
MA1587.1	NN 70-40%	JASPAR	CCTCGACCTCCTGA	50.0% identity		Open · Scan

ModCRE5

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
DIMER_sp_Q86UE3_ZN546_HUMAN:720:767_1llm_D_1	ModCRE	Homology model	CCACGCGCCGGG	Region 720-767 · 1 3D model		Open · Scan
TFS_sp_Q86UE3_ZN546_HUMAN:718:827_5egb_A_1	ModCRE	Homology model	TTCTGGGGGGGGGGGGGG	Region 718-827 · 1 3D model		Open · Scan
TFS_sp_Q86UE3_ZN546_HUMAN:718:827_5ei9_E_1	ModCRE	Homology model	CCCCCGGGGGGGGGTCC	Region 718-827 · 1 3D model		Open · Scan
TFS_sp_Q86UE3_ZN546_HUMAN:720:827_5eh2_F_1	ModCRE	Homology model	CCCCGGGCGGGCCGGGGCA	Region 720-827 · 1 3D model		Open · Scan
TFS_sp_Q86UE3_ZN546_HUMAN:720:830_6e94_A_1	ModCRE	Homology model	AAGCGGGCGACGGCCCGC	Region 720-830 · 1 3D model		Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 836 aa

217-830

Region 217-830 5 PWM

Residues

614 aa

Domains

PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type

3D models

10 active PDBs · 6 summary rows

Templates

1LLM, 2I13, 5EGB, 5EH2, 5EI9, 5V3J, 5V3M, 5WJQ, ...

Sources

Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

10 active PDB models 6 summary rows

Region 217-83010 models · 6 summary rows

Source ↕	Model ↕	Template ↕	Residues modeled ↕	Actions
Predicted = Low	DIMER_sp_Q86UE3_ZN546_HUMAN:720:767_1llm_D_1	1llm	720-767	View model · PDB
Predicted = Low	TFS_sp_Q86UE3_ZN546_HUMAN:217:492_5v3j_E_1	5v3j	217-492	View model · PDB
Predicted = Low	TFS_sp_Q86UE3_ZN546_HUMAN:217:492_5v3m_C_1	5v3m	217-492	View model · PDB
Predicted = Low	TFS_sp_Q86UE3_ZN546_HUMAN:383:660_5wjq_D_1	5wjq	383-660	View model · PDB
Predicted = Low	TFS_sp_Q86UE3_ZN546_HUMAN:385:683_7w1m_H_1	7w1m	385-683	View model · PDB
Predicted = Low	TFS_sp_Q86UE3_ZN546_HUMAN:674:827_2i13_A_1	2i13	674-827	View model · PDB
Predicted = Low	TFS_sp_Q86UE3_ZN546_HUMAN:718:827_5egb_A_1	5egb	718-827	View model · PDB
Predicted = Low	TFS_sp_Q86UE3_ZN546_HUMAN:718:827_5ei9_E_1	5ei9	718-827	View model · PDB
Predicted = Low	TFS_sp_Q86UE3_ZN546_HUMAN:720:827_5eh2_F_1	5eh2	720-827	View model · PDB
Predicted = Low	TFS_sp_Q86UE3_ZN546_HUMAN:720:830_6e94_A_1	6e94	720-830	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
4	2i13	191:830	674	827	P:A · DNA:C,D	59.1% / 66.9%	100	View · PDB TFS_sp_Q86UE3_ZN546_HUMAN:674:827_2i13_A_1
1	5wjq	191:830	383	660	P:D · DNA:A,B	57.9% / 71.9%	98	View · PDB TFS_sp_Q86UE3_ZN546_HUMAN:383:660_5wjq_D_1
2	5v3m	191:830	217	492	P:C · DNA:A,B	55.4% / 71.0%	99	View · PDB TFS_sp_Q86UE3_ZN546_HUMAN:217:492_5v3m_C_1
3	5v3j	191:830	217	492	P:E · DNA:A,B	55.4% / 71.0%	99	View · PDB TFS_sp_Q86UE3_ZN546_HUMAN:217:492_5v3j_E_1
1	1llm	191:830	720,720	767,767	P:C,D · DNA:A,B	50.0% / 62.5%	55,56	View · PDB DIMER_sp_Q86UE3_ZN546_HUMAN:720:767_1llm_D_1
5	7w1m	191:830	385	683	P:H · DNA:F,G	35.1% / 49.0%	92	View · PDB TFS_sp_Q86UE3_ZN546_HUMAN:385:683_7w1m_H_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
59-100	PF01352	KRAB box	No overlap with loaded model regions
217-239	PF00096	Zinc finger, C2H2 type	overlaps 217-830
245-267	PF00096	Zinc finger, C2H2 type	overlaps 217-830
273-295	PF00096	Zinc finger, C2H2 type	overlaps 217-830
301-323	PF00096	Zinc finger, C2H2 type	overlaps 217-830
329-351	PF00096	Zinc finger, C2H2 type	overlaps 217-830
357-379	PF00096	Zinc finger, C2H2 type	overlaps 217-830
385-407	PF00096	Zinc finger, C2H2 type	overlaps 217-830
413-435	PF00096	Zinc finger, C2H2 type	overlaps 217-830
441-463	PF00096	Zinc finger, C2H2 type	overlaps 217-830
469-491	PF00096	Zinc finger, C2H2 type	overlaps 217-830
497-519	PF00096	Zinc finger, C2H2 type	overlaps 217-830
525-547	PF00096	Zinc finger, C2H2 type	overlaps 217-830
553-575	PF00096	Zinc finger, C2H2 type	overlaps 217-830
581-603	PF00096	Zinc finger, C2H2 type	overlaps 217-830
609-631	PF00096	Zinc finger, C2H2 type	overlaps 217-830
637-659	PF00096	Zinc finger, C2H2 type	overlaps 217-830
665-687	PF00096	Zinc finger, C2H2 type	overlaps 217-830
721-743	PF00096	Zinc finger, C2H2 type	overlaps 217-830
749-771	PF00096	Zinc finger, C2H2 type	overlaps 217-830
777-799	PF00096	Zinc finger, C2H2 type	overlaps 217-830
805-827	PF00096	Zinc finger, C2H2 type	overlaps 217-830