ModCRE DB

Transcription factor

Q8IYA7 - MKX

Homeobox protein Mohawk

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 352 aa

35 Generated PWM 16 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)23
MotifPredictionSourceDNA bindingSupportLogoActions
M02229_2.00 NN 70-40% CisBP AGTACATGTTT 61.4% identity Open · Scan
M06519_2.00 NN 70-40% CisBP TAACA 58.9% identity Open · Scan
M02096_2.00 NN 70-40% CisBP TTGACAAG 56.6% identity Open · Scan
M00453_2.00 NN 70-40% CisBP ATTACATGAT 56.0% identity Open · Scan
M02060_2.00 NN 70-40% CisBP TTTGACAGCA 55.8% identity Open · Scan
M03859_2.00 NN 70-40% CisBP TGACAG 54.5% identity Open · Scan
M06346_2.00 NN 70-40% CisBP TTGACA 54.5% identity Open · Scan
MA0796.1 NN 70-40% JASPAR TGACAGCTGTCA 54.5% identity Open · Scan
M02032_2.00 NN 70-40% CisBP TGACATGTCA 54.1% identity Open · Scan
M02064_2.00 NN 70-40% CisBP ATTACAAG 53.7% identity Open · Scan
M05316_2.00 NN 70-40% CisBP ACGCGTACAACGCGT 53.6% identity Open · Scan
M08574_2.00 NN 70-40% CisBP TTTGACAG 53.4% identity Open · Scan
M08208_2.00 NN 70-40% CisBP GAGTTGTAGT 52.7% identity Open · Scan
M00416_2.00 NN 70-40% CisBP AATTACAA 52.1% identity Open · Scan
M02161_2.00 NN 70-40% CisBP TGACATGT 51.2% identity Open · Scan
M00425_2.00 NN 70-40% CisBP TGATACCC 51.1% identity Open · Scan
M06268_2.00 NN 70-40% CisBP AATGATA 51.1% identity Open · Scan
MA1118.1 NN 70-40% JASPAR GTAACCTGATA 51.1% identity Open · Scan
MA1119.1 NN 70-40% JASPAR AACTGAAACCTGATAC 51.1% identity Open · Scan
MA0782.1 NN 70-40% JASPAR TGACAGGTGTCA 50.0% identity Open · Scan
MA0783.1 NN 70-40% JASPAR TGACAGGTGTCA 50.0% identity Open · Scan
MA0797.1 NN 70-40% JASPAR TGACAGCTGTCA 50.0% identity Open · Scan
MA1571.1 NN 70-40% JASPAR TGACAGCTGTCA 50.0% identity Open · Scan
ModCRE12
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_sp_Q8IYA7_MKX_HUMAN:72:132_5zjr_B_1 ModCRE Homology model GAAATTCATCATAG Region 72-132 · 1 3D model Open · Scan
DIMER_sp_Q8IYA7_MKX_HUMAN:72:132_5zjt_B_1 ModCRE Homology model TTGATTCGTCAAGG Region 72-132 · 1 3D model Open · Scan
DIMER_sp_Q8IYA7_MKX_HUMAN:85:128_4xrm_A_1 ModCRE Homology model CTTGATTAAAATCAAG Region 85-128 · 1 3D model Open · Scan
DIMER_sp_Q8IYA7_MKX_HUMAN:85:128_6fqp_A_1 ModCRE Homology model CTAAATTTAAATCACC Region 85-128 · 1 3D model Open · Scan
DIMER_sp_Q8IYA7_MKX_HUMAN:85:128_6fqq_A_1 ModCRE Homology model GTTGACACATCCCTG Region 85-128 · 1 3D model Open · Scan
DIMER_sp_Q8IYA7_MKX_HUMAN:85:128_6fqq_D_1 ModCRE Homology model ATGATTCAACGGCTT Region 85-128 · 1 3D model Open · Scan
TFS_sp_Q8IYA7_MKX_HUMAN:72:132_5zjq_B_1 ModCRE Homology model GGGGTTAATCAAAG Region 72-132 · 1 3D model Open · Scan
TFS_sp_Q8IYA7_MKX_HUMAN:72:132_5zjr_B_1 ModCRE Homology model TGGGGGCATCAAAG Region 72-132 · 1 3D model Open · Scan
TFS_sp_Q8IYA7_MKX_HUMAN:72:132_5zjs_B_1 ModCRE Homology model TTGGGACATCAAGG Region 72-132 · 1 3D model Open · Scan
TFS_sp_Q8IYA7_MKX_HUMAN:72:132_5zjt_B_1 ModCRE Homology model TTGGGTCATCAAGG Region 72-132 · 1 3D model Open · Scan
TFS_sp_Q8IYA7_MKX_HUMAN:74:132_2r5z_B_1 ModCRE Homology model CCCTGGTATTATCGAAT Region 74-132 · 1 3D model Open · Scan
TFS_sp_Q8IYA7_MKX_HUMAN:85:128_5ego_A_1 ModCRE Homology model CTCGGGATGACAAT Region 85-128 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 352 aa
70-132

Region 70-132 12 PWM

Residues
63 aa
Domains
PF05920 · Homeobox KN domain
3D models
16 active PDBs · 10 summary rows
Templates
2R5Z, 4XRM, 5EGO, 5ZJQ, 5ZJR, 5ZJS, 5ZJT, 6FQP, ...
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
16 active PDB models 10 summary rows
Region 70-13216 models · 10 summary rows
Actions
Predicted = Low DIMER_sp_Q8IYA7_MKX_HUMAN:72:132_5zjr_B_1 5zjr 72-132 View model · PDB
Predicted = Low DIMER_sp_Q8IYA7_MKX_HUMAN:72:132_5zjt_B_1 5zjt 72-132 View model · PDB
Predicted = Low DIMER_sp_Q8IYA7_MKX_HUMAN:85:128_4xrm_A_1 4xrm 85-128 View model · PDB
Predicted = Low DIMER_sp_Q8IYA7_MKX_HUMAN:85:128_6fqp_A_1 6fqp 85-128 View model · PDB
Predicted = Low DIMER_sp_Q8IYA7_MKX_HUMAN:85:128_6fqq_A_1 6fqq 85-128 View model · PDB
Predicted = Low DIMER_sp_Q8IYA7_MKX_HUMAN:85:128_6fqq_D_1 6fqq 85-128 View model · PDB
Predicted = Low TFS_sp_Q8IYA7_MKX_HUMAN:72:132_5zjq_B_1 5zjq 72-132 View model · PDB
Predicted = Low TFS_sp_Q8IYA7_MKX_HUMAN:72:132_5zjr_B_1 5zjr 72-132 View model · PDB
Predicted = Low TFS_sp_Q8IYA7_MKX_HUMAN:72:132_5zjs_B_1 5zjs 72-132 View model · PDB
Predicted = Low TFS_sp_Q8IYA7_MKX_HUMAN:72:132_5zjt_B_1 5zjt 72-132 View model · PDB
Predicted = Low TFS_sp_Q8IYA7_MKX_HUMAN:74:132_2r5z_B_1 2r5z 74-132 View model · PDB
Predicted = Low TFS_sp_Q8IYA7_MKX_HUMAN:85:128_4xrm_A_1 4xrm 85-128 View model · PDB
Predicted = Low TFS_sp_Q8IYA7_MKX_HUMAN:85:128_5ego_A_1 5ego 85-128 View model · PDB
Predicted = Low TFS_sp_Q8IYA7_MKX_HUMAN:85:128_6fqp_A_1 6fqp 85-128 View model · PDB
Predicted = Low TFS_sp_Q8IYA7_MKX_HUMAN:85:128_6fqq_A_1 6fqq 85-128 View model · PDB
Predicted = Low TFS_sp_Q8IYA7_MKX_HUMAN:85:128_6fqq_D_1 6fqq 85-128 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
1 6fqq 68:138 85,85 128,128 P:B,D · DNA:L,M 54.5% / 75.0% 72,69 View · PDB TFS_sp_Q8IYA7_MKX_HUMAN:85:128_6fqq_D_1
1 6fqq 68:138 85,85 128,128 P:B,D · DNA:L,M 54.5% / 75.0% 72,69 View · PDB DIMER_sp_Q8IYA7_MKX_HUMAN:85:128_6fqq_D_1
2 6fqp 68:138 85,70 128,128 P:A,B · DNA:L,M 54.5% / 75.0% 65,89 View · PDB TFS_sp_Q8IYA7_MKX_HUMAN:85:128_6fqp_A_1
2 6fqp 68:138 85,70 128,128 P:A,B · DNA:L,M 54.5% / 75.0% 65,89 View · PDB DIMER_sp_Q8IYA7_MKX_HUMAN:85:128_6fqp_A_1
3 6fqq 68:138 85,85 128,128 P:A,D · DNA:L,M 54.5% / 75.0% 73,69 View · PDB TFS_sp_Q8IYA7_MKX_HUMAN:85:128_6fqq_A_1
3 6fqq 68:138 85,85 128,128 P:A,D · DNA:L,M 54.5% / 75.0% 73,69 View · PDB DIMER_sp_Q8IYA7_MKX_HUMAN:85:128_6fqq_A_1
4 4xrm 68:138 85,85 128,128 P:A,B · DNA:L,M 45.5% / 77.3% 74,68 View · PDB TFS_sp_Q8IYA7_MKX_HUMAN:85:128_4xrm_A_1
4 4xrm 68:138 85,85 128,128 P:A,B · DNA:L,M 45.5% / 77.3% 74,68 View · PDB DIMER_sp_Q8IYA7_MKX_HUMAN:85:128_4xrm_A_1
5 5ego 68:138 85 128 P:A · DNA:D,E 45.5% / 77.3% 77 View · PDB TFS_sp_Q8IYA7_MKX_HUMAN:85:128_5ego_A_1
5 5zjr 68:138 95,72 129,132 P:A,B · DNA:C,D 37.7% / 54.1% 54,82 View · PDB DIMER_sp_Q8IYA7_MKX_HUMAN:72:132_5zjr_B_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
88-127PF05920Homeobox KN domainoverlaps 70-132