Transcription factor

Q8NFU7 - TET1

Methylcytosine dioxygenase TET1 (EC 1.14.11.80) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 2136 aa

7 Generated PWM 7 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known1

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
M01914_2.00	Known	CisBP	ATCGCGTTA	Direct PWM		Open · Scan

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)1

Motif	Prediction	Source	DNA binding	Support	Logo	Actions
M01908_2.00	NN 70-40%	CisBP	TTTGCGG	56.0% identity		Open · Scan

ModCRE5

Motif	Prediction	Source	DNA binding	Support	Actions
TFS_sp_Q8NFU7_TET1_HUMAN:586:628_4nw3_A_1	ModCRE	Homology model	CACGCCGCGCGC	Region 586-628 · 1 3D model	Open · Scan
TFS_sp_Q8NFU7_TET1_HUMAN:586:629_5w9s_C_1	ModCRE	Homology model	CCCCGCGTGGTG	Region 586-629 · 1 3D model	Open · Scan
TFS_sp_Q8NFU7_TET1_HUMAN:586:632_2kkf_A_1	ModCRE	Homology model	AACCCCGGGGGG	Region 586-632 · 1 3D model	Open · Scan
TFS_sp_Q8NFU7_TET1_HUMAN:587:630_3pt6_A_1	ModCRE	Homology model	CACGGCCCCCCCGGG	Region 587-630 · 1 3D model	Open · Scan
TFS_sp_Q8NFU7_TET1_HUMAN:587:630_6asd_C_1	ModCRE	Homology model	CCCCCCCGGGGG	Region 587-630 · 1 3D model	Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 2136 aa

586-632

Region 586-632 5 PWM

Residues: 47 aa
Domains: PF02008 · CXXC zinc finger domain
3D models: 7 active PDBs · 7 summary rows
Templates: 1HCQ, 2KKF, 3PT6, 4AA6, 4NW3, 5W9S, 6ASD
Sources: Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

7 active PDB models 7 summary rows

Region 586-6327 models · 7 summary rows

				Actions
Predicted = Low	DIMER_sp_Q8NFU7_TET1_HUMAN:605:627_1hcq_B_1	1hcq	605-627	View model · PDB
Predicted = Low	DIMER_sp_Q8NFU7_TET1_HUMAN:605:627_4aa6_B_1	4aa6	605-627	View model · PDB
Predicted = Low	TFS_sp_Q8NFU7_TET1_HUMAN:586:628_4nw3_A_1	4nw3	586-628	View model · PDB
Predicted = Low	TFS_sp_Q8NFU7_TET1_HUMAN:586:629_5w9s_C_1	5w9s	586-629	View model · PDB
Predicted = Low	TFS_sp_Q8NFU7_TET1_HUMAN:586:632_2kkf_A_1	2kkf	586-632	View model · PDB
Predicted = Low	TFS_sp_Q8NFU7_TET1_HUMAN:587:630_3pt6_A_1	3pt6	587-630	View model · PDB
Predicted = Low	TFS_sp_Q8NFU7_TET1_HUMAN:587:630_6asd_C_1	6asd	587-630	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
1	6asd	586:632	587	630	P:C · DNA:A,B	100.0% / 100.0%	100	View · PDB TFS_sp_Q8NFU7_TET1_HUMAN:587:630_6asd_C_1
2	5w9s	586:632	586	629	P:C · DNA:A,B	68.2% / 84.1%	100	View · PDB TFS_sp_Q8NFU7_TET1_HUMAN:586:629_5w9s_C_1
1	4aa6	586:632	605,605	627,627	P:A,B · DNA:C,D	52.2% / 69.6%	33,33	View · PDB DIMER_sp_Q8NFU7_TET1_HUMAN:605:627_4aa6_B_1
2	1hcq	586:632	605,605	627,627	P:A,B · DNA:C,D	52.2% / 69.6%	31,32	View · PDB DIMER_sp_Q8NFU7_TET1_HUMAN:605:627_1hcq_B_1
4	3pt6	586:632	587	630	P:A · DNA:C,I	48.0% / 56.0%	4	View · PDB TFS_sp_Q8NFU7_TET1_HUMAN:587:630_3pt6_A_1
3	2kkf	586:632	586	632	P:A · DNA:B,C	39.6% / 52.8%	82	View · PDB TFS_sp_Q8NFU7_TET1_HUMAN:586:632_2kkf_A_1
5	4nw3	586:632	586	628	P:A · DNA:B,C	38.8% / 53.1%	84	View · PDB TFS_sp_Q8NFU7_TET1_HUMAN:586:628_4nw3_A_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
585-624	PF02008	CXXC zinc finger domain	overlaps 586-632
1580-2052	PF12851	Oxygenase domain of the 2OGFeDO superfamily	No overlap with loaded model regions