ModCRE DB

Transcription factor

Q96IT1 - ZNF496

Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 587 aa

19 Generated PWM 11 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known1
MotifPredictionSourceDNA bindingSupportLogoActions
M07609_2.00 Known CisBP ATTGCGCCACTGCACTCCAGCCTGGGCAAC Direct PWM Open · Scan
Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)7
MotifPredictionSourceDNA bindingSupportLogoActions
MA1602.1 NN 70-40% JASPAR CGTCTACACGGG 69.6% identity Open · Scan
M00764_2.00 NN 70-40% CisBP GTCTACAC 68.5% identity Open · Scan
M04611_2.00 NN 70-40% CisBP CTTTCGGACAC 65.5% identity Open · Scan
M04530_2.00 NN 70-40% CisBP CCGTCCCCCTCCCCCC 63.1% identity Open · Scan
MA1124.1 NN 70-40% JASPAR CATTCATTCATTC 61.4% identity Open · Scan
M07562_2.00 NN 70-40% CisBP GAAAAAAAC 57.7% identity Open · Scan
M00769_2.00 NN 70-40% CisBP ACTCCCCC 52.8% identity Open · Scan
ModCRE11
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_sp_Q96IT1_ZN496_HUMAN:433:496_1llm_D_1 ModCRE Homology model GTTCCGCGCGAA Region 433-496 · 1 3D model Open · Scan
TFS_sp_Q96IT1_ZN496_HUMAN:388:485_5ei9_E_1 ModCRE Homology model CCCCCCGGGGGGGTGGG Region 388-485 · 1 3D model Open · Scan
TFS_sp_Q96IT1_ZN496_HUMAN:399:575_5v3j_E_1 ModCRE Homology model CTGGGGGGGCCTGGGGGGGGAC Region 399-575 · 1 3D model Open · Scan
TFS_sp_Q96IT1_ZN496_HUMAN:399:575_5v3m_C_1 ModCRE Homology model TGGGGGTGCAGGTGGGGGCACG Region 399-575 · 1 3D model Open · Scan
TFS_sp_Q96IT1_ZN496_HUMAN:401:575_5wjq_D_1 ModCRE Homology model CCGTGGGGAGCTTGGGGCGGGGGC Region 401-575 · 1 3D model Open · Scan
TFS_sp_Q96IT1_ZN496_HUMAN:404:541_2i13_A_1 ModCRE Homology model AAAAAAAAGGTTAGTATCCCC Region 404-541 · 1 3D model Open · Scan
TFS_sp_Q96IT1_ZN496_HUMAN:521:575_2kmk_A_1 ModCRE Homology model CCCGCGGGCCCCCC Region 521-575 · 1 3D model Open · Scan
TFS_sp_Q96IT1_ZN496_HUMAN:522:575_5v3j_E_1 ModCRE Homology model GTCCGGGGGGGCCCC Region 522-575 · 1 3D model Open · Scan
TFS_sp_Q96IT1_ZN496_HUMAN:522:575_5v3m_C_1 ModCRE Homology model TGGGGGGGGCGGTT Region 522-575 · 1 3D model Open · Scan
TFS_sp_Q96IT1_ZN496_HUMAN:522:575_5wjq_D_1 ModCRE Homology model TCGGGGGGGCTGCC Region 522-575 · 1 3D model Open · Scan
TFS_sp_Q96IT1_ZN496_HUMAN:522:575_6e94_A_1 ModCRE Homology model GGCACGGGATTGAAA Region 522-575 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 587 aa
388-575

Region 388-575 11 PWM

Residues
188 aa
Domains
PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type
3D models
11 active PDBs · 6 summary rows
Templates
1LLM, 2I13, 2KMK, 5EI9, 5V3J, 5V3M, 5WJQ, 6E94
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
11 active PDB models 6 summary rows
Region 388-57511 models · 6 summary rows
Actions
Predicted = Low DIMER_sp_Q96IT1_ZN496_HUMAN:433:496_1llm_D_1 1llm 433-496 View model · PDB
Predicted = Low TFS_sp_Q96IT1_ZN496_HUMAN:388:485_5ei9_E_1 5ei9 388-485 View model · PDB
Predicted = Low TFS_sp_Q96IT1_ZN496_HUMAN:399:575_5v3j_E_1 5v3j 399-575 View model · PDB
Predicted = Low TFS_sp_Q96IT1_ZN496_HUMAN:399:575_5v3m_C_1 5v3m 399-575 View model · PDB
Predicted = Low TFS_sp_Q96IT1_ZN496_HUMAN:401:575_5wjq_D_1 5wjq 401-575 View model · PDB
Predicted = Low TFS_sp_Q96IT1_ZN496_HUMAN:404:541_2i13_A_1 2i13 404-541 View model · PDB
Predicted = Low TFS_sp_Q96IT1_ZN496_HUMAN:521:575_2kmk_A_1 2kmk 521-575 View model · PDB
Predicted = Low TFS_sp_Q96IT1_ZN496_HUMAN:522:575_5v3j_E_1 5v3j 522-575 View model · PDB
Predicted = Low TFS_sp_Q96IT1_ZN496_HUMAN:522:575_5v3m_C_1 5v3m 522-575 View model · PDB
Predicted = Low TFS_sp_Q96IT1_ZN496_HUMAN:522:575_5wjq_D_1 5wjq 522-575 View model · PDB
Predicted = Low TFS_sp_Q96IT1_ZN496_HUMAN:522:575_6e94_A_1 6e94 522-575 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
5 5ei9 388:579 388 485 P:E · DNA:A,B 39.8% / 54.1% 87 View · PDB TFS_sp_Q96IT1_ZN496_HUMAN:388:485_5ei9_E_1
1 2i13 388:579 404 541 P:A · DNA:C,D 35.5% / 50.0% 88 View · PDB TFS_sp_Q96IT1_ZN496_HUMAN:404:541_2i13_A_1
1 1llm 388:579 433,433 496,496 P:C,D · DNA:A,B 35.4% / 52.3% 73,75 View · PDB DIMER_sp_Q96IT1_ZN496_HUMAN:433:496_1llm_D_1
3 5v3m 388:579 399 575 P:C · DNA:A,B 32.8% / 48.0% 61 View · PDB TFS_sp_Q96IT1_ZN496_HUMAN:399:575_5v3m_C_1
4 5v3j 388:579 399 575 P:E · DNA:A,B 32.8% / 48.0% 61 View · PDB TFS_sp_Q96IT1_ZN496_HUMAN:399:575_5v3j_E_1
2 5wjq 388:579 401 575 P:D · DNA:A,B 32.6% / 52.0% 59 View · PDB TFS_sp_Q96IT1_ZN496_HUMAN:401:575_5wjq_D_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
38-126PF02023SCAN domainNo overlap with loaded model regions
223-248PF01352KRAB boxNo overlap with loaded model regions
406-426PF00096Zinc finger, C2H2 typeoverlaps 388-575
463-485PF00096Zinc finger, C2H2 typeoverlaps 388-575
553-575PF00096Zinc finger, C2H2 typeoverlaps 388-575