ModCRE DB

Transcription factor

Q96NK8 - NEUROD6

Neurogenic differentiation factor 6 (NeuroD6) (Class A basic helix-loop-helix protein 2) (bHLHa2) (Protein atonal homolog 2)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 337 aa

40 Generated PWM 14 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)28
MotifPredictionSourceDNA bindingSupportLogoActions
MA0623.1 NN 70-40% JASPAR ACCATATGGT 64.4% identity Open · Scan
MA0623.2 NN 70-40% JASPAR GACATATGTC 64.4% identity Open · Scan
MA0669.1 NN 70-40% JASPAR AACATATGTC 63.9% identity Open · Scan
M05980_2.00 NN 70-40% CisBP CACAGCTGAC 60.6% identity Open · Scan
MA0607.1 NN 70-40% JASPAR CCATATGT 60.3% identity Open · Scan
MA1472.1 NN 70-40% JASPAR AACAGCTGTT 60.3% identity Open · Scan
M05976_2.00 NN 70-40% CisBP ACCATATGGCG 58.9% identity Open · Scan
M01729_2.00 NN 70-40% CisBP AACATATGGT 57.6% identity Open · Scan
M05952_2.00 NN 70-40% CisBP ACCATCTGCCG 57.6% identity Open · Scan
MA0818.1 NN 70-40% JASPAR ACCATATGTT 57.6% identity Open · Scan
M05967_2.00 NN 70-40% CisBP TGACATATGG 57.3% identity Open · Scan
MA0461.1 NN 70-40% JASPAR CAGATGGC 56.7% identity Open · Scan
MA1467.1 NN 70-40% JASPAR AACAGCTGTC 56.7% identity Open · Scan
MA1109.1 NN 70-40% JASPAR GGACAGATGGCAG 55.9% identity Open · Scan
MA1468.1 NN 70-40% JASPAR AACATATGTC 55.8% identity Open · Scan
M05986_2.00 NN 70-40% CisBP ACCGCACCATCTGTC 55.2% identity Open · Scan
M05951_2.00 NN 70-40% CisBP ACCACCTGT 54.5% identity Open · Scan
MA1485.1 NN 70-40% JASPAR GCAACAGCTGTTAC 54.5% identity Open · Scan
M05962_2.00 NN 70-40% CisBP CCACCTGCC 54.3% identity Open · Scan
MA0678.1 NN 70-40% JASPAR ACCATATGGT 54.2% identity Open · Scan
MA0827.1 NN 70-40% JASPAR ACCATATGTT 54.2% identity Open · Scan
MA0668.1 NN 70-40% JASPAR GCCATATGGT 53.9% identity Open · Scan
M02784_2.00 NN 70-40% CisBP ACCATATGTT 52.6% identity Open · Scan
MA0817.1 NN 70-40% JASPAR AAACATATGTTT 52.6% identity Open · Scan
M04156_2.00 NN 70-40% CisBP AACAGCTGACGC 50.0% identity Open · Scan
MA0832.1 NN 70-40% JASPAR GCAACAGCTGTTGT 50.0% identity Open · Scan
MA1568.1 NN 70-40% JASPAR CACCATATGGCG 50.0% identity Open · Scan
MA1618.1 NN 70-40% JASPAR AAACAGATGTTTA 50.0% identity Open · Scan
ModCRE12
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_sp_Q96NK8_NDF6_HUMAN:95:150_2ypa_A_1 ModCRE Homology model CCCACATGGGG Region 95-150 · 1 3D model Open · Scan
DIMER_sp_Q96NK8_NDF6_HUMAN:95:150_2ypb_A_1 ModCRE Homology model CCCATATGGGT Region 95-150 · 1 3D model Open · Scan
DIMER_sp_Q96NK8_NDF6_HUMAN:95:151_1mdy_B_1 ModCRE Homology model GGGCCAGCTGGGCG Region 95-151 · 1 3D model Open · Scan
DIMER_sp_Q96NK8_NDF6_HUMAN:95:151_2ql2_B_1 ModCRE Homology model GTCACCATATGGCCCC Region 95-151 · 1 3D model Open · Scan
TFS_sp_Q96NK8_NDF6_HUMAN:95:149_7z5k_B_1 ModCRE Homology model GGTACCCATATGGGTAGC Region 95-149 · 1 3D model Open · Scan
TFS_sp_Q96NK8_NDF6_HUMAN:95:150_2ypa_A_1 ModCRE Homology model CCCCATGTGGG Region 95-150 · 1 3D model Open · Scan
TFS_sp_Q96NK8_NDF6_HUMAN:95:150_2ypb_A_1 ModCRE Homology model CCCCATATGGG Region 95-150 · 1 3D model Open · Scan
TFS_sp_Q96NK8_NDF6_HUMAN:95:151_1mdy_A_1 ModCRE Homology model TAACCATATGGGCA Region 95-151 · 1 3D model Open · Scan
TFS_sp_Q96NK8_NDF6_HUMAN:95:151_1mdy_B_1 ModCRE Homology model GGCACAGCTGGGCC Region 95-151 · 1 3D model Open · Scan
TFS_sp_Q96NK8_NDF6_HUMAN:95:151_2ql2_B_1 ModCRE Homology model AGGGCCATATGTTTGC Region 95-151 · 1 3D model Open · Scan
TFS_sp_Q96NK8_NDF6_HUMAN:95:151_6od3_B_1 ModCRE Homology model GCCACAGTGGGG Region 95-151 · 1 3D model Open · Scan
TFS_sp_Q96NK8_NDF6_HUMAN:95:151_6od5_B_1 ModCRE Homology model AGCCAGCTGCGC Region 95-151 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 337 aa
91-151

Region 91-151 12 PWM

Residues
61 aa
Domains
PF00010 · Helix-loop-helix DNA-binding domain
3D models
14 active PDBs · 10 summary rows
Templates
1MDY, 2QL2, 2YPA, 2YPB, 6OD3, 6OD5, 7Z5I, 7Z5K
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
14 active PDB models 10 summary rows
Region 91-15114 models · 10 summary rows
Actions
Predicted = Low DIMER_sp_Q96NK8_NDF6_HUMAN:95:148_7z5i_B_1 7z5i 95-148 View model · PDB
Predicted = Low DIMER_sp_Q96NK8_NDF6_HUMAN:95:149_7z5k_B_1 7z5k 95-149 View model · PDB
Predicted = Low DIMER_sp_Q96NK8_NDF6_HUMAN:95:150_2ypa_A_1 2ypa 95-150 View model · PDB
Predicted = Low DIMER_sp_Q96NK8_NDF6_HUMAN:95:150_2ypb_A_1 2ypb 95-150 View model · PDB
Predicted = Low DIMER_sp_Q96NK8_NDF6_HUMAN:95:151_1mdy_B_1 1mdy 95-151 View model · PDB
Predicted = Low DIMER_sp_Q96NK8_NDF6_HUMAN:95:151_2ql2_B_1 2ql2 95-151 View model · PDB
Predicted = Low TFS_sp_Q96NK8_NDF6_HUMAN:95:149_7z5k_B_1 7z5k 95-149 View model · PDB
Predicted = Low TFS_sp_Q96NK8_NDF6_HUMAN:95:150_2ypa_A_1 2ypa 95-150 View model · PDB
Predicted = Low TFS_sp_Q96NK8_NDF6_HUMAN:95:150_2ypb_A_1 2ypb 95-150 View model · PDB
Predicted = Low TFS_sp_Q96NK8_NDF6_HUMAN:95:151_1mdy_A_1 1mdy 95-151 View model · PDB
Predicted = Low TFS_sp_Q96NK8_NDF6_HUMAN:95:151_1mdy_B_1 1mdy 95-151 View model · PDB
Predicted = Low TFS_sp_Q96NK8_NDF6_HUMAN:95:151_2ql2_B_1 2ql2 95-151 View model · PDB
Predicted = Low TFS_sp_Q96NK8_NDF6_HUMAN:95:151_6od3_B_1 6od3 95-151 View model · PDB
Predicted = Low TFS_sp_Q96NK8_NDF6_HUMAN:95:151_6od5_B_1 6od5 95-151 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
1 2ql2 91:151 95 151 P:B · DNA:E,F 94.7% / 96.5% 96 View · PDB TFS_sp_Q96NK8_NDF6_HUMAN:95:151_2ql2_B_1
1 2ypb 91:151 95,91 150,151 P:A,B · DNA:E,F 46.4% / 62.5% 83,82 View · PDB DIMER_sp_Q96NK8_NDF6_HUMAN:95:150_2ypb_A_1
2 2ypa 91:151 95,91 150,151 P:A,B · DNA:E,F 46.4% / 62.5% 83,83 View · PIR DIMER_sp_Q96NK8_NDF6_HUMAN:95:150_2ypa_A_1
2 2ypb 91:151 95,91 150,151 P:A,B · DNA:E,F 46.4% / 62.5% 83,82 View · PDB TFS_sp_Q96NK8_NDF6_HUMAN:95:150_2ypb_A_1
3 2ypa 91:151 95,91 150,151 P:A,B · DNA:E,F 46.4% / 62.5% 83,83 View · PDB TFS_sp_Q96NK8_NDF6_HUMAN:95:150_2ypa_A_1
5 7z5i 91:151 95,95 148,148 P:A,B · DNA:E,F 38.9% / 57.4% 94,94 View · PDB DIMER_sp_Q96NK8_NDF6_HUMAN:95:148_7z5i_B_1
3 1mdy 91:151 95,95 151,151 P:A,B · DNA:E,F 38.6% / 57.9% 82,90 View · PDB DIMER_sp_Q96NK8_NDF6_HUMAN:95:151_1mdy_B_1
4 1mdy 91:151 95,95 151,151 P:A,B · DNA:E,F 38.6% / 57.9% 82,90 View · PDB TFS_sp_Q96NK8_NDF6_HUMAN:95:151_1mdy_B_1
4 7z5k 91:151 95,95 148,149 P:A,B · DNA:E,F 38.2% / 58.2% 94,96 View · PDB DIMER_sp_Q96NK8_NDF6_HUMAN:95:149_7z5k_B_1
5 7z5k 91:151 95,95 148,149 P:A,B · DNA:E,F 38.2% / 58.2% 94,96 View · PDB TFS_sp_Q96NK8_NDF6_HUMAN:95:149_7z5k_B_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
95-145PF00010Helix-loop-helix DNA-binding domainoverlaps 91-151
153-272PF12533Neuronal helix-loop-helix transcription factorNo overlap with loaded model regions