ModCRE DB

Transcription factor

Q96SQ7 - ATOH8

Transcription factor ATOH8 (Class A basic helix-loop-helix protein 21) (bHLHa21) (Helix-loop-helix protein hATH-6) (hATH6) (Protein atonal homolog 8)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 321 aa

20 Generated PWM 14 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)6
MotifPredictionSourceDNA bindingSupportLogoActions
M05951_2.00 NN 70-40% CisBP ACCACCTGT 60.0% identity Open · Scan
MA0668.1 NN 70-40% JASPAR GCCATATGGT 58.1% identity Open · Scan
MA1109.1 NN 70-40% JASPAR GGACAGATGGCAG 58.1% identity Open · Scan
M05980_2.00 NN 70-40% CisBP CACAGCTGAC 52.5% identity Open · Scan
M00930_2.00 NN 70-40% CisBP CATATATG 50.0% identity Open · Scan
MA0607.1 NN 70-40% JASPAR CCATATGT 50.0% identity Open · Scan
ModCRE14
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_sp_Q96SQ7_ATOH8_HUMAN:228:282_5i50_B_1 ModCRE Homology model TGGGGGGCCACGTGGAGTCCAC Region 228-282 · 1 3D model Open · Scan
DIMER_sp_Q96SQ7_ATOH8_HUMAN:230:285_2ql2_B_1 ModCRE Homology model GTAAACACGTGTTTCC Region 230-285 · 1 3D model Open · Scan
DIMER_sp_Q96SQ7_ATOH8_HUMAN:231:282_6od3_B_1 ModCRE Homology model GCCCAGCTGGGC Region 231-282 · 1 3D model Open · Scan
DIMER_sp_Q96SQ7_ATOH8_HUMAN:231:282_6od4_B_1 ModCRE Homology model CCAGTTGGT Region 231-282 · 1 3D model Open · Scan
DIMER_sp_Q96SQ7_ATOH8_HUMAN:231:285_1mdy_B_1 ModCRE Homology model CTAGCAGCTGGGAG Region 231-285 · 1 3D model Open · Scan
DIMER_sp_Q96SQ7_ATOH8_HUMAN:231:285_2ypa_A_1 ModCRE Homology model CCCACCTGGGT Region 231-285 · 1 3D model Open · Scan
DIMER_sp_Q96SQ7_ATOH8_HUMAN:231:285_2ypb_A_1 ModCRE Homology model ACCAGGTGGAC Region 231-285 · 1 3D model Open · Scan
TFS_sp_Q96SQ7_ATOH8_HUMAN:228:282_5i50_B_1 ModCRE Homology model GAGGGCTCCACGTGGCCCCCCA Region 228-282 · 1 3D model Open · Scan
TFS_sp_Q96SQ7_ATOH8_HUMAN:230:285_2ql2_B_1 ModCRE Homology model CTAAAAATATGCTTAT Region 230-285 · 1 3D model Open · Scan
TFS_sp_Q96SQ7_ATOH8_HUMAN:231:282_6od3_B_1 ModCRE Homology model GCACAGGTGTGG Region 231-282 · 1 3D model Open · Scan
TFS_sp_Q96SQ7_ATOH8_HUMAN:231:282_6od4_B_1 ModCRE Homology model GCAGTTGGC Region 231-282 · 1 3D model Open · Scan
TFS_sp_Q96SQ7_ATOH8_HUMAN:231:282_6od5_B_1 ModCRE Homology model CGTCAGCTGCGC Region 231-282 · 1 3D model Open · Scan
TFS_sp_Q96SQ7_ATOH8_HUMAN:231:285_2ypa_A_1 ModCRE Homology model ACACAGGTGGG Region 231-285 · 1 3D model Open · Scan
TFS_sp_Q96SQ7_ATOH8_HUMAN:231:285_2ypb_A_1 ModCRE Homology model ATACACCTGGT Region 231-285 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 321 aa
228-285

Region 228-285 14 PWM

Residues
58 aa
Domains
PF00010 · Helix-loop-helix DNA-binding domain
3D models
14 active PDBs · 10 summary rows
Templates
1MDY, 2QL2, 2YPA, 2YPB, 5I50, 6OD3, 6OD4, 6OD5
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
14 active PDB models 10 summary rows
Region 228-28514 models · 10 summary rows
Actions
Predicted = Low DIMER_sp_Q96SQ7_ATOH8_HUMAN:228:282_5i50_B_1 5i50 228-282 View model · PDB
Predicted = Low DIMER_sp_Q96SQ7_ATOH8_HUMAN:230:285_2ql2_B_1 2ql2 230-285 View model · PDB
Predicted = Low DIMER_sp_Q96SQ7_ATOH8_HUMAN:231:282_6od3_B_1 6od3 231-282 View model · PDB
Predicted = Low DIMER_sp_Q96SQ7_ATOH8_HUMAN:231:282_6od4_B_1 6od4 231-282 View model · PDB
Predicted = Low DIMER_sp_Q96SQ7_ATOH8_HUMAN:231:285_1mdy_B_1 1mdy 231-285 View model · PDB
Predicted = Low DIMER_sp_Q96SQ7_ATOH8_HUMAN:231:285_2ypa_A_1 2ypa 231-285 View model · PDB
Predicted = Low DIMER_sp_Q96SQ7_ATOH8_HUMAN:231:285_2ypb_A_1 2ypb 231-285 View model · PDB
Predicted = Low TFS_sp_Q96SQ7_ATOH8_HUMAN:228:282_5i50_B_1 5i50 228-282 View model · PDB
Predicted = Low TFS_sp_Q96SQ7_ATOH8_HUMAN:230:285_2ql2_B_1 2ql2 230-285 View model · PDB
Predicted = Low TFS_sp_Q96SQ7_ATOH8_HUMAN:231:282_6od3_B_1 6od3 231-282 View model · PDB
Predicted = Low TFS_sp_Q96SQ7_ATOH8_HUMAN:231:282_6od4_B_1 6od4 231-282 View model · PDB
Predicted = Low TFS_sp_Q96SQ7_ATOH8_HUMAN:231:282_6od5_B_1 6od5 231-282 View model · PDB
Predicted = Low TFS_sp_Q96SQ7_ATOH8_HUMAN:231:285_2ypa_A_1 2ypa 231-285 View model · PDB
Predicted = Low TFS_sp_Q96SQ7_ATOH8_HUMAN:231:285_2ypb_A_1 2ypb 231-285 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
1 2ql2 228:285 230 285 P:B · DNA:E,F 57.1% / 76.8% 94 View · PDB TFS_sp_Q96SQ7_ATOH8_HUMAN:230:285_2ql2_B_1
1 2ypb 228:285 231,231 285,282 P:A,B · DNA:E,F 47.3% / 63.6% 82,70 View · PIR DIMER_sp_Q96SQ7_ATOH8_HUMAN:231:285_2ypb_A_1
2 2ypa 228:285 231,231 285,282 P:A,B · DNA:E,F 47.3% / 63.6% 82,71 View · PDB DIMER_sp_Q96SQ7_ATOH8_HUMAN:231:285_2ypa_A_1
2 2ypb 228:285 231,231 285,282 P:A,B · DNA:E,F 47.3% / 63.6% 82,70 View · PDB TFS_sp_Q96SQ7_ATOH8_HUMAN:231:285_2ypb_A_1
3 2ypa 228:285 231,231 285,282 P:A,B · DNA:E,F 47.3% / 63.6% 82,71 View · PDB TFS_sp_Q96SQ7_ATOH8_HUMAN:231:285_2ypa_A_1
4 6od4 228:285 231,231 282,282 P:A,B · DNA:W,X 45.3% / 56.6% 85,85 View · PDB DIMER_sp_Q96SQ7_ATOH8_HUMAN:231:282_6od4_B_1
5 6od3 228:285 231,231 282,282 P:A,B · DNA:W,X 45.3% / 56.6% 83,85 View · PDB DIMER_sp_Q96SQ7_ATOH8_HUMAN:231:282_6od3_B_1
5 6od4 228:285 231,231 282,282 P:A,B · DNA:W,X 45.3% / 56.6% 85,85 View · PDB TFS_sp_Q96SQ7_ATOH8_HUMAN:231:282_6od4_B_1
3 5i50 228:285 228,228 282,282 P:A,B · DNA:C,D 36.4% / 54.5% 59,57 View · PDB DIMER_sp_Q96SQ7_ATOH8_HUMAN:228:282_5i50_B_1
4 5i50 228:285 228,228 282,282 P:A,B · DNA:C,D 36.4% / 54.5% 59,57 View · PDB TFS_sp_Q96SQ7_ATOH8_HUMAN:228:282_5i50_B_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
231-282PF00010Helix-loop-helix DNA-binding domainoverlaps 228-285