Transcription factor

Q9BRR0 - ZKSCAN3

Zinc finger protein with KRAB and SCAN domains 3 (Zinc finger and SCAN domain-containing protein 13) (Zinc finger protein 306) (Zinc finger protein 309) (Zinc finger protein 47 homolog) (Zf47) (Zfp-47)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 538 aa

98 Generated PWM 11 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known4

Motif	Prediction	Source	DNA binding	Support	Actions
MA1973.1	Known	JASPAR	GGGCCCAGGCTAGCCCACGC	Direct PWM	Open · Scan
MA1973.2	Known	JASPAR	CCCAGGCTAGCCCA	Direct PWM	Open · Scan
M02923_2.00	Known	CisBP	TCGAGGCTAGACCA	Direct PWM	Open · Scan
M07696_2.00	Known	CisBP	GGCTAGCCC	Direct PWM	Open · Scan

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)84

Motif	Prediction	Source	DNA binding	Support	Actions
M00939_2.00	NN 70-40%	CisBP	CCACCTCA	69.4% identity	Open · Scan
M00943_2.00	NN 70-40%	CisBP	CCCGCTGC	68.2% identity	Open · Scan
M00960_2.00	NN 70-40%	CisBP	TGCATCCC	68.2% identity	Open · Scan
M00944_2.00	NN 70-40%	CisBP	TCGCTATAA	67.0% identity	Open · Scan
M00948_2.00	NN 70-40%	CisBP	GCAGCACC	67.0% identity	Open · Scan
M00950_2.00	NN 70-40%	CisBP	GCAGCCCA	67.0% identity	Open · Scan
M00953_2.00	NN 70-40%	CisBP	ATCTATAT	67.0% identity	Open · Scan
M00958_2.00	NN 70-40%	CisBP	CGGCATCCC	67.0% identity	Open · Scan
M04653_2.00	NN 70-40%	CisBP	GGTACGGTTGTCCATGTTGCAA	66.1% identity	Open · Scan
M00952_2.00	NN 70-40%	CisBP	GGATGCTC	65.8% identity	Open · Scan
M00955_2.00	NN 70-40%	CisBP	ACGTCCTCT	65.8% identity	Open · Scan
M00959_2.00	NN 70-40%	CisBP	GCCCTCCC	65.8% identity	Open · Scan
M04598_2.00	NN 70-40%	CisBP	CGCTAACTCTCCACA	61.8% identity	Open · Scan
M08325_2.00	NN 70-40%	CisBP	TTTTTTTTT	61.3% identity	Open · Scan
M00945_2.00	NN 70-40%	CisBP	CACCGCAC	59.7% identity	Open · Scan
M04387_2.00	NN 70-40%	CisBP	CGTGCTCCCC	58.5% identity	Open · Scan
M08267_2.00	NN 70-40%	CisBP	CAGTTTCATTTTCC	57.9% identity	Open · Scan
M04505_2.00	NN 70-40%	CisBP	AGCTTTTCCCACAC	57.8% identity	Open · Scan
M07689_2.00	NN 70-40%	CisBP	ACCCAGGCTCCTTCCATCTTGTGGCTC	57.6% identity	Open · Scan
M08355_2.00	NN 70-40%	CisBP	GCGAACTCCTATTCATCC	56.7% identity	Open · Scan
M08245_2.00	NN 70-40%	CisBP	TGGTGCCTTATTCCC	55.7% identity	Open · Scan
M07635_2.00	NN 70-40%	CisBP	AAGTTTTCTTGTATTATATCT	55.4% identity	Open · Scan
M08347_2.00	NN 70-40%	CisBP	GCCCTGGGCAGC	55.2% identity	Open · Scan
MA1587.1	NN 70-40%	JASPAR	CCTCGACCTCCTGA	54.5% identity	Open · Scan
M07666_2.00	NN 70-40%	CisBP	ATCTAGCCCCTGCCTACC	54.3% identity	Open · Scan
M08934_2.00	NN 70-40%	CisBP	GCTGTACCTGCTTATTAGGC	54.1% identity	Open · Scan
M08917_2.00	NN 70-40%	CisBP	GCTGAGCCATGTGGGGTGCT	53.9% identity	Open · Scan
MA0740.1	NN 70-40%	JASPAR	GGCCACGCCCCCTT	53.9% identity	Open · Scan
M05844_2.00	NN 70-40%	CisBP	TCACCTGT	53.3% identity	Open · Scan
M08540_2.00	NN 70-40%	CisBP	CCCCT	53.3% identity	Open · Scan
MA0103.1	NN 70-40%	JASPAR	CACCTG	53.3% identity	Open · Scan
MA0103.2	NN 70-40%	JASPAR	CCTCACCTG	53.3% identity	Open · Scan
M07753_2.00	NN 70-40%	CisBP	TGCATTCCTTGGCTTGTG	53.2% identity	Open · Scan
M08860_2.00	NN 70-40%	CisBP	TCTTATAAGGGCACTAATCCCATT	53.2% identity	Open · Scan
M04621_2.00	NN 70-40%	CisBP	AGCAATTCCGCTCA	52.9% identity	Open · Scan
M08300_2.00	NN 70-40%	CisBP	CTGCCCAATTCAT	52.9% identity	Open · Scan
MA1589.1	NN 70-40%	JASPAR	TAGGAGTGGAATTGCTGGGTC	52.9% identity	Open · Scan
M07605_2.00	NN 70-40%	CisBP	TATTTTTTTTTATTTTTTTTTTTTTTTTTT	52.8% identity	Open · Scan
M08256_2.00	NN 70-40%	CisBP	GTGCCTT	52.7% identity	Open · Scan
M08279_2.00	NN 70-40%	CisBP	CCTCCCTCC	52.7% identity	Open · Scan
M04463_2.00	NN 70-40%	CisBP	CACCACGCCCA	52.6% identity	Open · Scan
MA0039.1	NN 70-40%	JASPAR	TAAAGGAAGG	52.6% identity	Open · Scan
MA0039.3	NN 70-40%	JASPAR	CCACACCCTGC	52.6% identity	Open · Scan
MA1515.1	NN 70-40%	JASPAR	CACCACGCCCA	52.6% identity	Open · Scan
M07686_2.00	NN 70-40%	CisBP	TAGCTTGTTTCCAGCCAC	52.5% identity	Open · Scan
MA0741.1	NN 70-40%	JASPAR	GCCACGCCCCC	52.5% identity	Open · Scan
M07610_2.00	NN 70-40%	CisBP	CCTTCTTCCTCCCCCCTGCCCACC	52.3% identity	Open · Scan
M00782_2.00	NN 70-40%	CisBP	AGTGTGCGCTA	52.2% identity	Open · Scan
M07588_2.00	NN 70-40%	CisBP	TCCTTCCCTCTTTCC	52.2% identity	Open · Scan
M07699_2.00	NN 70-40%	CisBP	GGTTTAT	52.2% identity	Open · Scan
M08371_2.00	NN 70-40%	CisBP	CCAGACTTGTCCTCT	51.9% identity	Open · Scan
M07761_2.00	NN 70-40%	CisBP	CTGATTATTCACCCA	51.7% identity	Open · Scan
M07587_2.00	NN 70-40%	CisBP	CCCCCTCCCCAGTCGAGCCCCCGC	51.5% identity	Open · Scan
M00609_2.00	NN 70-40%	CisBP	GGAAGCCCTA	51.3% identity	Open · Scan
M03702_2.00	NN 70-40%	CisBP	GACCCCCCACGACGC	51.2% identity	Open · Scan
MA0493.1	NN 70-40%	JASPAR	GGCCACACCCA	51.2% identity	Open · Scan
M08908_2.00	NN 70-40%	CisBP	GCTGCTGCTTCTGCTG	51.1% identity	Open · Scan
M07691_2.00	NN 70-40%	CisBP	CCTGCAGCCACCTTGGCCTTG	51.0% identity	Open · Scan
M08252_2.00	NN 70-40%	CisBP	CCGGCTCCAGCACCC	51.0% identity	Open · Scan
M01474_2.00	NN 70-40%	CisBP	CGCCGATCAC	50.9% identity	Open · Scan
M01538_2.00	NN 70-40%	CisBP	GCCCCTGA	50.9% identity	Open · Scan
M07598_2.00	NN 70-40%	CisBP	CTGACAATACCAAGTGTTGAC	50.9% identity	Open · Scan
M07660_2.00	NN 70-40%	CisBP	CCGCGCCTACCTGAGGGCGCGGGCCTGGGG	50.9% identity	Open · Scan
M08977_2.00	NN 70-40%	CisBP	AAATCACAGC	50.9% identity	Open · Scan
M07678_2.00	NN 70-40%	CisBP	CCCGCCCCCTCCTCCCCCTTCCCACCC	50.8% identity	Open · Scan
M07700_2.00	NN 70-40%	CisBP	ATGTTGTGAGGAAGCCCA	50.8% identity	Open · Scan
M08255_2.00	NN 70-40%	CisBP	CTCTTCCGGT	50.7% identity	Open · Scan
M07593_2.00	NN 70-40%	CisBP	AGATGAAGTCACCCCTCTTAC	50.6% identity	Open · Scan
M03671_2.00	NN 70-40%	CisBP	ATTACCATACAAGTGCAC	50.4% identity	Open · Scan
M07727_2.00	NN 70-40%	CisBP	CGCCGCCTCCCC	50.4% identity	Open · Scan
M08329_2.00	NN 70-40%	CisBP	GCTGCATAGTATTCC	50.4% identity	Open · Scan
MA0750.1	NN 70-40%	JASPAR	GGCGACCACCGA	50.4% identity	Open · Scan
MA1596.1	NN 70-40%	JASPAR	GCCTCAGCCTCCCGAG	50.4% identity	Open · Scan
M08311_2.00	NN 70-40%	CisBP	CTGGAACAGAAGGGGCGA	50.3% identity	Open · Scan
M08395_2.00	NN 70-40%	CisBP	GCTGCCTACTCTTCC	50.3% identity	Open · Scan
M07762_2.00	NN 70-40%	CisBP	GCCGCGCACAGGCTTCTAGCC	50.2% identity	Open · Scan
M08399_2.00	NN 70-40%	CisBP	TACTCTGGGGCCACATGACTC	50.2% identity	Open · Scan
M08375_2.00	NN 70-40%	CisBP	TTCCCCATTGGCTACTGCACCGGTCCT	50.1% identity	Open · Scan
M00143_2.00	NN 70-40%	CisBP	CCCCCCCACG	50.0% identity	Open · Scan
M00224_2.00	NN 70-40%	CisBP	CCCGCCCC	50.0% identity	Open · Scan
M06179_2.00	NN 70-40%	CisBP	TAAGCCTATAGA	50.0% identity	Open · Scan
M07562_2.00	NN 70-40%	CisBP	GAAAAAAAC	50.0% identity	Open · Scan
M09008_2.00	NN 70-40%	CisBP	CCCGGCCCCACCCT	50.0% identity	Open · Scan
MA0753.1	NN 70-40%	JASPAR	CCCCCCCCAC	50.0% identity	Open · Scan

ModCRE10

Motif	Prediction	Source	DNA binding	Support	Actions
TFS_sp_Q9BRR0_ZKSC3_HUMAN:279:338_6e93_A_1	ModCRE	Homology model	GGGAACTATGTTGC	Region 279-338 · 1 3D model	Open · Scan
TFS_sp_Q9BRR0_ZKSC3_HUMAN:279:338_6e94_A_1	ModCRE	Homology model	GGAACCTATAGTTAA	Region 279-338 · 1 3D model	Open · Scan
TFS_sp_Q9BRR0_ZKSC3_HUMAN:280:338_2i13_A_1	ModCRE	Homology model	AGTACTTTGGCGTTCCC	Region 280-338 · 1 3D model	Open · Scan
TFS_sp_Q9BRR0_ZKSC3_HUMAN:280:530_5wjq_D_1	ModCRE	Homology model	GCGGGGCCCCGCGGGGGCTCCGTTGCCT	Region 280-530 · 1 3D model	Open · Scan
TFS_sp_Q9BRR0_ZKSC3_HUMAN:291:338_5wjq_D_1	ModCRE	Homology model	ACGCGGGATTTGTAA	Region 291-338 · 1 3D model	Open · Scan
TFS_sp_Q9BRR0_ZKSC3_HUMAN:291:533_5v3j_E_1	ModCRE	Homology model	GAGTGGGGGGGCCAGGGGGGGGG	Region 291-533 · 1 3D model	Open · Scan
TFS_sp_Q9BRR0_ZKSC3_HUMAN:291:533_5v3m_C_1	ModCRE	Homology model	GACGGGGCGGGGGGGGGGGGCCGC	Region 291-533 · 1 3D model	Open · Scan
TFS_sp_Q9BRR0_ZKSC3_HUMAN:297:338_1ubd_C_1	ModCRE	Homology model	CCCCGGGCCCCGGA	Region 297-338 · 1 3D model	Open · Scan
TFS_sp_Q9BRR0_ZKSC3_HUMAN:301:448_2i13_A_1	ModCRE	Homology model	TTTCAGTACGACTCTGTATAT	Region 301-448 · 1 3D model	Open · Scan
TFS_sp_Q9BRR0_ZKSC3_HUMAN:339:449_5ei9_E_1	ModCRE	Homology model	CCCCCCGGGGGCGGTCA	Region 339-449 · 1 3D model	Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 538 aa

279-533

Region 279-533 10 PWM

Residues: 255 aa
Domains: PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type
3D models: 11 active PDBs · 6 summary rows
Templates: 1LLM, 1UBD, 2I13, 5EI9, 5V3J, 5V3M, 5WJQ, 6E93, ...
Sources: Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

11 active PDB models 6 summary rows

Region 279-53311 models · 6 summary rows

				Actions
Predicted = Low	DIMER_sp_Q9BRR0_ZKSC3_HUMAN:396:447_1llm_D_1	1llm	396-447	View model · PDB
Predicted = Low	TFS_sp_Q9BRR0_ZKSC3_HUMAN:279:338_6e93_A_1	6e93	279-338	View model · PDB
Predicted = Low	TFS_sp_Q9BRR0_ZKSC3_HUMAN:279:338_6e94_A_1	6e94	279-338	View model · PDB
Predicted = Low	TFS_sp_Q9BRR0_ZKSC3_HUMAN:280:338_2i13_A_1	2i13	280-338	View model · PDB
Predicted = Low	TFS_sp_Q9BRR0_ZKSC3_HUMAN:280:530_5wjq_D_1	5wjq	280-530	View model · PDB
Predicted = Low	TFS_sp_Q9BRR0_ZKSC3_HUMAN:291:338_5wjq_D_1	5wjq	291-338	View model · PDB
Predicted = Low	TFS_sp_Q9BRR0_ZKSC3_HUMAN:291:533_5v3j_E_1	5v3j	291-533	View model · PDB
Predicted = Low	TFS_sp_Q9BRR0_ZKSC3_HUMAN:291:533_5v3m_C_1	5v3m	291-533	View model · PDB
Predicted = Low	TFS_sp_Q9BRR0_ZKSC3_HUMAN:297:338_1ubd_C_1	1ubd	297-338	View model · PDB
Predicted = Low	TFS_sp_Q9BRR0_ZKSC3_HUMAN:301:448_2i13_A_1	2i13	301-448	View model · PDB
Predicted = Low	TFS_sp_Q9BRR0_ZKSC3_HUMAN:339:449_5ei9_E_1	5ei9	339-449	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
5	5ei9	252:536	339	449	P:E · DNA:A,B	61.3% / 69.4%	100	View · PDB TFS_sp_Q9BRR0_ZKSC3_HUMAN:339:449_5ei9_E_1
4	2i13	252:536	301	448	P:A · DNA:C,D	55.4% / 68.2%	96	View · PDB TFS_sp_Q9BRR0_ZKSC3_HUMAN:301:448_2i13_A_1
1	1llm	252:536	396,396	447,447	P:C,D · DNA:A,B	48.1% / 63.5%	59,61	View · PDB DIMER_sp_Q9BRR0_ZKSC3_HUMAN:396:447_1llm_D_1
2	5v3m	252:536	291	533	P:C · DNA:A,B	46.1% / 62.0%	87	View · PDB TFS_sp_Q9BRR0_ZKSC3_HUMAN:291:533_5v3m_C_1
3	5v3j	252:536	291	533	P:E · DNA:A,B	46.1% / 62.0%	87	View · PDB TFS_sp_Q9BRR0_ZKSC3_HUMAN:291:533_5v3j_E_1
1	5wjq	252:536	280	530	P:D · DNA:A,B	43.9% / 61.3%	89	View · PDB TFS_sp_Q9BRR0_ZKSC3_HUMAN:280:530_5wjq_D_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
43-130	PF02023	SCAN domain	No overlap with loaded model regions
216-253	PF01352	KRAB box	No overlap with loaded model regions
314-336	PF00096	Zinc finger, C2H2 type	overlaps 279-533
342-364	PF00096	Zinc finger, C2H2 type	overlaps 279-533
370-392	PF00096	Zinc finger, C2H2 type	overlaps 279-533
398-420	PF00096	Zinc finger, C2H2 type	overlaps 279-533
426-448	PF00096	Zinc finger, C2H2 type	overlaps 279-533
480-502	PF00096	Zinc finger, C2H2 type	overlaps 279-533
508-530	PF00096	Zinc finger, C2H2 type	overlaps 279-533