Transcription factor

Q9NPC8 - SIX2

Homeobox protein SIX2 (Sine oculis homeobox homolog 2)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 291 aa

9 Generated PWM 1 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known9

Motif	Prediction	Source	DNA binding	Support	Actions
MA1119.1	Known	JASPAR	AACTGAAACCTGATAC	Direct PWM	Open · Scan
MA1119.2	Known	JASPAR	TGAAACCTGAT	Direct PWM	Open · Scan
M05285_2.00	Known	CisBP	GATGATACGG	Direct PWM	Open · Scan
M05286_2.00	Known	CisBP	GCGTATCGTG	Direct PWM	Open · Scan
M05287_2.00	Known	CisBP	CCGTATCACC	Direct PWM	Open · Scan
M05288_2.00	Known	CisBP	ACGTATCATG	Direct PWM	Open · Scan
M08133_2.00	Known	CisBP	AACTGAAACCTGATAC	Direct PWM	Open · Scan
M09157_2.00	Known	CisBP	TGAAACCTGAGAC	Direct PWM	Open · Scan
SIX2_HUMAN.H11MO.0.A	Known	HOCOMOCO	TGAAACCTGAGAC	Direct PWM	Open · Scan

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)0

No generated PWM in this category.

ModCRE0

No generated PWM in this category.

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 291 aa

131-178

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

1 active PDB model

Region 131-1781 model

				Actions
Predicted = Low	DIMER_Q9NPC8:131:178_1b8i_B_1	1b8i	131-178	View model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
9-119	PF16878	Transcriptional regulator, SIX1, N-terminal SD domain	No overlap with loaded model regions
130-180	PF00046	Homeodomain	overlaps 131-178