ModCRE DB

Transcription factor

Q9NQ33 - ASCL3

Achaete-scute homolog 3 (ASH-3) (hASH3) (Class A basic helix-loop-helix protein 42) (bHLHa42) (bHLH transcriptional regulator Sgn-1)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 181 aa

17 Generated PWM 13 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)10
MotifPredictionSourceDNA bindingSupportLogoActions
M04210_2.00 NN 70-40% CisBP AGCAGCTGCC 57.6% identity Open · Scan
MA0816.1 NN 70-40% JASPAR AGCAGCTGCT 55.5% identity Open · Scan
MA1100.1 NN 70-40% JASPAR GCAGCAGCTGGCG 53.5% identity Open · Scan
M04156_2.00 NN 70-40% CisBP AACAGCTGACGC 51.8% identity Open · Scan
MA1618.1 NN 70-40% JASPAR AAACAGATGTTTA 51.8% identity Open · Scan
M00756_2.00 NN 70-40% CisBP CGCAGCTGTG 51.0% identity Open · Scan
MA0048.1 NN 70-40% JASPAR GCGCAGCTGCGT 51.0% identity Open · Scan
MA1529.1 NN 70-40% JASPAR GGGCCGCAGCTGCGTCCC 51.0% identity Open · Scan
MA0091.1 NN 70-40% JASPAR CGACCATCTGTT 50.9% identity Open · Scan
MA1485.1 NN 70-40% JASPAR GCAACAGCTGTTAC 50.9% identity Open · Scan
ModCRE7
MotifPredictionSourceDNA bindingSupportLogoActions
DIMER_sp_Q9NQ33_ASCL3_HUMAN:101:146_7z5i_B_1 ModCRE Homology model CCCTCACAGCTGTGCGGG Region 101-146 · 1 3D model Open · Scan
DIMER_sp_Q9NQ33_ASCL3_HUMAN:101:148_7z5k_B_1 ModCRE Homology model CCCACCCAGCTGTGGGGG Region 101-148 · 1 3D model Open · Scan
DIMER_sp_Q9NQ33_ASCL3_HUMAN:101:149_1mdy_B_1 ModCRE Homology model GCACCAGCTGTGTC Region 101-149 · 1 3D model Open · Scan
DIMER_sp_Q9NQ33_ASCL3_HUMAN:126:146_1am9_B_1 ModCRE Homology model CCACCCGGGGCCGCGCGGCCGCGC Region 126-146 · 1 3D model Open · Scan
DIMER_sp_Q9NQ33_ASCL3_HUMAN:126:146_1am9_D_1 ModCRE Homology model GCGTGGCCCCGCGGGTCGCGGTG Region 126-146 · 1 3D model Open · Scan
DIMER_sp_Q9NQ33_ASCL3_HUMAN:97:149_2ql2_B_1 ModCRE Homology model CCCAAAAGCTGGCTCC Region 97-149 · 1 3D model Open · Scan
TFS_sp_Q9NQ33_ASCL3_HUMAN:101:149_1mdy_A_1 ModCRE Homology model GAAACAGCTGGCTC Region 101-149 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 181 aa
97-149

Region 97-149 7 PWM

Residues
53 aa
Domains
PF00010 · Helix-loop-helix DNA-binding domain
3D models
13 active PDBs · 10 summary rows
Templates
1AM9, 1MDY, 2QL2, 2YPA, 2YPB, 7Z5I, 7Z5K
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
13 active PDB models 10 summary rows
Region 97-14913 models · 10 summary rows
Actions
Predicted = Low DIMER_sp_Q9NQ33_ASCL3_HUMAN:101:146_7z5i_B_1 7z5i 101-146 View model · PDB
Predicted = Low DIMER_sp_Q9NQ33_ASCL3_HUMAN:101:148_7z5k_B_1 7z5k 101-148 View model · PDB
Predicted = Low DIMER_sp_Q9NQ33_ASCL3_HUMAN:101:149_1mdy_B_1 1mdy 101-149 View model · PDB
Predicted = Low DIMER_sp_Q9NQ33_ASCL3_HUMAN:126:146_1am9_B_1 1am9 126-146 View model · PDB
Predicted = Low DIMER_sp_Q9NQ33_ASCL3_HUMAN:126:146_1am9_C_1 1am9 126-146 View model · PDB
Predicted = Low DIMER_sp_Q9NQ33_ASCL3_HUMAN:126:146_1am9_D_1 1am9 126-146 View model · PDB
Predicted = Low DIMER_sp_Q9NQ33_ASCL3_HUMAN:97:149_2ql2_B_1 2ql2 97-149 View model · PDB
Predicted = Low TFS_sp_Q9NQ33_ASCL3_HUMAN:101:148_7z5k_B_1 7z5k 101-148 View model · PDB
Predicted = Low TFS_sp_Q9NQ33_ASCL3_HUMAN:101:149_1mdy_A_1 1mdy 101-149 View model · PDB
Predicted = Low TFS_sp_Q9NQ33_ASCL3_HUMAN:101:149_1mdy_B_1 1mdy 101-149 View model · PDB
Predicted = Low TFS_sp_Q9NQ33_ASCL3_HUMAN:97:149_2ql2_B_1 2ql2 97-149 View model · PDB
Predicted = Low TFS_sp_Q9NQ33_ASCL3_HUMAN:99:149_2ypa_A_1 2ypa 99-149 View model · PDB
Predicted = Low TFS_sp_Q9NQ33_ASCL3_HUMAN:99:149_2ypb_A_1 2ypb 99-149 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
4 1am9 97:149 126,126 146,146 P:B,D · DNA:E,F,G,H 52.4% / 66.7% 28,27 View · PDB DIMER_sp_Q9NQ33_ASCL3_HUMAN:126:146_1am9_B_1
5 1am9 97:149 126,126 146,146 P:C,D · DNA:E,F,G,H 52.4% / 66.7% 25,27 View · PDB DIMER_sp_Q9NQ33_ASCL3_HUMAN:126:146_1am9_C_1
1 2ypb 97:149 99 149 P:A · DNA:E,F 51.0% / 66.7% 76 View · PDB TFS_sp_Q9NQ33_ASCL3_HUMAN:99:149_2ypb_A_1
2 2ypa 97:149 99 149 P:A · DNA:E,F 51.0% / 66.7% 76 View · PDB TFS_sp_Q9NQ33_ASCL3_HUMAN:99:149_2ypa_A_1
1 1mdy 97:149 101,101 149,149 P:A,B · DNA:E,F 46.9% / 61.2% 70,77 View · PDB DIMER_sp_Q9NQ33_ASCL3_HUMAN:101:149_1mdy_B_1
3 1mdy 97:149 101,101 149,149 P:A,B · DNA:E,F 46.9% / 61.2% 70,77 View · PDB TFS_sp_Q9NQ33_ASCL3_HUMAN:101:149_1mdy_A_1
2 7z5k 97:149 101,101 146,148 P:A,B · DNA:E,F 45.8% / 60.4% 80,83 View · PDB DIMER_sp_Q9NQ33_ASCL3_HUMAN:101:148_7z5k_B_1
5 7z5k 97:149 101,101 146,148 P:A,B · DNA:E,F 45.8% / 60.4% 80,83 View · PDB TFS_sp_Q9NQ33_ASCL3_HUMAN:101:148_7z5k_B_1
3 7z5i 97:149 101,101 146,146 P:A,B · DNA:E,F 45.7% / 60.9% 80,80 View · PDB DIMER_sp_Q9NQ33_ASCL3_HUMAN:101:146_7z5i_B_1
4 2ql2 97:149 97 149 P:B · DNA:E,F 41.5% / 54.7% 89 View · PDB TFS_sp_Q9NQ33_ASCL3_HUMAN:97:149_2ql2_B_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
96-146PF00010Helix-loop-helix DNA-binding domainoverlaps 97-149