ModCRE DB

Transcription factor

Q9UBB5 - MBD2

Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 411 aa

8 Generated PWM 5 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known2
MotifPredictionSourceDNA bindingSupportLogoActions
M09256_2.00 Known CisBP CGGGCCGGAGG Direct PWM Open · Scan
MBD2_HUMAN.H11MO.0.B Known HOCOMOCO CGGGCCGGAGG Direct PWM Open · Scan
Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)1
MotifPredictionSourceDNA bindingSupportLogoActions
M09257_2.00 NN 70-40% CisBP CCCGGAG 50.0% identity Open · Scan
ModCRE5
MotifPredictionSourceDNA bindingSupportLogoActions
TFS_sp_Q9UBB5_MBD2_HUMAN:145:204_6ogk_A_1 ModCRE Homology model TTATATAGT Region 145-204 · 1 3D model Open · Scan
TFS_sp_Q9UBB5_MBD2_HUMAN:145:216_6ogj_B_1 ModCRE Homology model CTCCCCA Region 145-216 · 1 3D model Open · Scan
TFS_sp_Q9UBB5_MBD2_HUMAN:147:204_3c2i_A_1 ModCRE Homology model CCCCCCACTTG Region 147-204 · 1 3D model Open · Scan
TFS_sp_Q9UBB5_MBD2_HUMAN:147:204_6c1y_A_1 ModCRE Homology model GGTGTGTGGCG Region 147-204 · 1 3D model Open · Scan
TFS_sp_Q9UBB5_MBD2_HUMAN:151:216_6ogj_A_1 ModCRE Homology model AATTAAATAAA Region 151-216 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 411 aa
145-216

Region 145-216 5 PWM

Residues
72 aa
Domains
PF01429 · Methyl-CpG binding domain
3D models
5 active PDBs · 5 summary rows
Templates
3C2I, 6C1Y, 6OGJ, 6OGK
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
5 active PDB models 5 summary rows
Region 145-2165 models · 5 summary rows
Actions
Predicted = Low TFS_sp_Q9UBB5_MBD2_HUMAN:145:204_6ogk_A_1 6ogk 145-204 View model · PDB
Predicted = Low TFS_sp_Q9UBB5_MBD2_HUMAN:145:216_6ogj_B_1 6ogj 145-216 View model · PDB
Predicted = Low TFS_sp_Q9UBB5_MBD2_HUMAN:147:204_3c2i_A_1 3c2i 147-204 View model · PDB
Predicted = Low TFS_sp_Q9UBB5_MBD2_HUMAN:147:204_6c1y_A_1 6c1y 147-204 View model · PDB
Predicted = Low TFS_sp_Q9UBB5_MBD2_HUMAN:151:216_6ogj_A_1 6ogj 151-216 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
4 6ogj 145:216 151 216 P:A · DNA:C,D 50.7% / 63.4% 86 View · PDB TFS_sp_Q9UBB5_MBD2_HUMAN:151:216_6ogj_A_1
3 3c2i 145:216 147 204 P:A · DNA:B,C 50.0% / 56.9% 80 View · PDB TFS_sp_Q9UBB5_MBD2_HUMAN:147:204_3c2i_A_1
5 6c1y 145:216 147 204 P:A · DNA:C,D 50.0% / 56.9% 81 View · PDB TFS_sp_Q9UBB5_MBD2_HUMAN:147:204_6c1y_A_1
2 6ogk 145:216 145 204 P:A · DNA:C,D 48.3% / 56.7% 78 View · PDB TFS_sp_Q9UBB5_MBD2_HUMAN:145:204_6ogk_A_1
1 6ogj 145:216 145 216 P:B · DNA:C,D 48.1% / 61.0% 87 View · PDB TFS_sp_Q9UBB5_MBD2_HUMAN:145:216_6ogj_B_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
148-214PF01429Methyl-CpG binding domainoverlaps 145-216
223-292PF16564p55-binding region of Methyl-CpG-binding domain proteins MBDNo overlap with loaded model regions
298-387PF14048C-terminal domain of methyl-CpG binding protein 2 and 3No overlap with loaded model regions