Transcription factor

Q9UIS9 - MBD1

Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 605 aa

8 Generated PWM 6 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known0

No generated PWM in this category.

Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)3

Motif	Prediction	Source	DNA binding	Support	Actions
M01907_2.00	NN 70-40%	CisBP	TTCGCGTAAACG	52.0% identity	Open · Scan
M01910_2.00	NN 70-40%	CisBP	GCGGAAATT	51.0% identity	Open · Scan
M01921_2.00	NN 70-40%	CisBP	AAATTACGGA	50.0% identity	Open · Scan

ModCRE5

Motif	Prediction	Source	DNA binding	Support	Actions
TFS_sp_Q9UIS9_MBD1_HUMAN:333:377_3qmb_A_1	ModCRE	Homology model	GACCCCGCGGGG	Region 333-377 · 1 3D model	Open · Scan
TFS_sp_Q9UIS9_MBD1_HUMAN:336:377_3qmc_A_1	ModCRE	Homology model	GCCCCCGCGGGG	Region 336-377 · 1 3D model	Open · Scan
TFS_sp_Q9UIS9_MBD1_HUMAN:336:377_3qmd_A_1	ModCRE	Homology model	CACCCCGCGGGG	Region 336-377 · 1 3D model	Open · Scan
TFS_sp_Q9UIS9_MBD1_HUMAN:336:377_3qmh_A_1	ModCRE	Homology model	CCCCGCCGCGGG	Region 336-377 · 1 3D model	Open · Scan
TFS_sp_Q9UIS9_MBD1_HUMAN:336:377_3qmi_A_1	ModCRE	Homology model	CCCCCCCGGGGG	Region 336-377 · 1 3D model	Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 605 aa

333-382

Region 333-382 5 PWM

Residues: 50 aa
Domains: PF02008 · CXXC zinc finger domain
3D models: 6 active PDBs · 6 summary rows
Templates: 3QMB, 3QMC, 3QMD, 3QMH, 3QMI, 4HN6
Sources: Predicted = Low

Scan this region Show models

3D Models

Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.

6 active PDB models 6 summary rows

Region 333-3826 models · 6 summary rows

				Actions
Predicted = Low	DIMER_sp_Q9UIS9_MBD1_HUMAN:338:382_4hn6_B_1	4hn6	338-382	View model · PDB
Predicted = Low	TFS_sp_Q9UIS9_MBD1_HUMAN:333:377_3qmb_A_1	3qmb	333-377	View model · PDB
Predicted = Low	TFS_sp_Q9UIS9_MBD1_HUMAN:336:377_3qmc_A_1	3qmc	336-377	View model · PDB
Predicted = Low	TFS_sp_Q9UIS9_MBD1_HUMAN:336:377_3qmd_A_1	3qmd	336-377	View model · PDB
Predicted = Low	TFS_sp_Q9UIS9_MBD1_HUMAN:336:377_3qmh_A_1	3qmh	336-377	View model · PDB
Predicted = Low	TFS_sp_Q9UIS9_MBD1_HUMAN:336:377_3qmi_A_1	3qmi	336-377	View model · PDB

Model-summary evidence imported for this region.

Rank	Template	Domain	N-tails	C-tails	Chains	Identity / similarity	Coverage	Model file
2	3qmd	333:383	336	377	P:A · DNA:B,C	66.7% / 69.0%	79	View · PDB TFS_sp_Q9UIS9_MBD1_HUMAN:336:377_3qmd_A_1
3	3qmc	333:383	336	377	P:A · DNA:B,C	66.7% / 69.0%	79	View · PDB TFS_sp_Q9UIS9_MBD1_HUMAN:336:377_3qmc_A_1
4	3qmh	333:383	336	377	P:A · DNA:B,C	66.7% / 69.0%	79	View · PDB TFS_sp_Q9UIS9_MBD1_HUMAN:336:377_3qmh_A_1
5	3qmi	333:383	336	377	P:A · DNA:B,C	66.7% / 69.0%	80	View · PDB TFS_sp_Q9UIS9_MBD1_HUMAN:336:377_3qmi_A_1
1	3qmb	333:383	333	377	P:A · DNA:B,C	64.4% / 66.7%	83	View · PDB TFS_sp_Q9UIS9_MBD1_HUMAN:333:377_3qmb_A_1
1	4hn6	333:383	338,338	382,382	P:A,B · DNA:C,D	30.6% / 51.0%	62,62	View · PDB DIMER_sp_Q9UIS9_MBD1_HUMAN:338:382_4hn6_B_1

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

Residues	PFAM	Domain	Used by prediction region?
2-70	PF01429	Methyl-CpG binding domain	No overlap with loaded model regions
169-215	PF02008	CXXC zinc finger domain	No overlap with loaded model regions
219-262	PF02008	CXXC zinc finger domain	No overlap with loaded model regions
331-377	PF02008	CXXC zinc finger domain	overlaps 333-382