ModCRE DB

Transcription factor

Q9UKS7 - IKZF2

Zinc finger protein Helios (Ikaros family zinc finger protein 2)

Homo sapiens (Human) · Reviewed (UniProtKB/Swiss-Prot) · 526 aa

13 Generated PWM 11 3D models

Motif Prediction

Only entries with a generated matrix are shown here.

Known1
MotifPredictionSourceDNA bindingSupportLogoActions
MA2326.1 Known JASPAR AGGAAG Direct PWM Open · Scan
Nearest Neighbor (>70%)0

No generated PWM in this category.

Nearest Neighbor (70% - 40%)2
MotifPredictionSourceDNA bindingSupportLogoActions
MA1508.1 NN 70-40% JASPAR GAAACAGGAAGT 55.4% identity Open · Scan
MA0744.1 NN 70-40% JASPAR ATGCAACAGGTGG 53.3% identity Open · Scan
ModCRE10
MotifPredictionSourceDNA bindingSupportLogoActions
TFS_sp_Q9UKS7_IKZF2_HUMAN:113:215_2i13_A_1 ModCRE Homology model AGGGTAAGCCCTCAGCGACA Region 113-215 · 1 3D model Open · Scan
TFS_sp_Q9UKS7_IKZF2_HUMAN:113:216_5wjq_D_1 ModCRE Homology model TCCTCGGGTTATCTGGGG Region 113-216 · 1 3D model Open · Scan
TFS_sp_Q9UKS7_IKZF2_HUMAN:114:215_5egb_A_1 ModCRE Homology model CACACCGGGGGAGCCTTT Region 114-215 · 1 3D model Open · Scan
TFS_sp_Q9UKS7_IKZF2_HUMAN:114:215_5eh2_F_1 ModCRE Homology model CCCCCCGTGGGGGGCGGGA Region 114-215 · 1 3D model Open · Scan
TFS_sp_Q9UKS7_IKZF2_HUMAN:114:215_5ei9_E_1 ModCRE Homology model AACCCTGTGGGGGACGG Region 114-215 · 1 3D model Open · Scan
TFS_sp_Q9UKS7_IKZF2_HUMAN:194:217_2kmk_A_1 ModCRE Homology model GGGGCCAGCGGC Region 194-217 · 1 3D model Open · Scan
TFS_sp_Q9UKS7_IKZF2_HUMAN:469:518_5kkq_A_1 ModCRE Homology model ACGCATAGGATTTT Region 469-518 · 1 3D model Open · Scan
TFS_sp_Q9UKS7_IKZF2_HUMAN:469:518_5t00_A_1 ModCRE Homology model CCCTAGAGGTTTTA Region 469-518 · 1 3D model Open · Scan
TFS_sp_Q9UKS7_IKZF2_HUMAN:469:518_5yeh_A_1 ModCRE Homology model AGGAGTGGTGG Region 469-518 · 1 3D model Open · Scan
TFS_sp_Q9UKS7_IKZF2_HUMAN:471:518_5k5h_A_1 ModCRE Homology model GTTGCCACTGT Region 471-518 · 1 3D model Open · Scan

Model-supported DNA-binding regions

Protein residue intervals where structure models support predicted PWMs. Domain annotations and modeled regions are shown together when available.

1 526 aa
113-219
469-518

Region 113-219 6 PWM

Residues
107 aa
Domains
PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type PF00096 · Zinc finger, C2H2 type
3D models
7 active PDBs · 6 summary rows
Templates
1LLM, 2I13, 2KMK, 5EGB, 5EH2, 5EI9, 5WJQ
Sources
Predicted = Low
Scan this region Show models

Region 469-518 4 PWM

Residues
50 aa
Domains
No overlapping PFAM annotation recorded
3D models
4 active PDBs
Templates
5K5H, 5KKQ, 5T00, 5YEH
Sources
Predicted = Low
Scan this region Show models
3D Models
Collapsible technical table. Rows are grouped by protein region and retain model, template, residue coverage, and available summary evidence.
11 active PDB models 6 summary rows
Region 113-2197 models · 6 summary rows
Actions
Predicted = Low DIMER_sp_Q9UKS7_IKZF2_HUMAN:166:219_1llm_C_1 1llm 166-219 View model · PDB
Predicted = Low TFS_sp_Q9UKS7_IKZF2_HUMAN:113:215_2i13_A_1 2i13 113-215 View model · PDB
Predicted = Low TFS_sp_Q9UKS7_IKZF2_HUMAN:113:216_5wjq_D_1 5wjq 113-216 View model · PDB
Predicted = Low TFS_sp_Q9UKS7_IKZF2_HUMAN:114:215_5egb_A_1 5egb 114-215 View model · PDB
Predicted = Low TFS_sp_Q9UKS7_IKZF2_HUMAN:114:215_5eh2_F_1 5eh2 114-215 View model · PDB
Predicted = Low TFS_sp_Q9UKS7_IKZF2_HUMAN:114:215_5ei9_E_1 5ei9 114-215 View model · PDB
Predicted = Low TFS_sp_Q9UKS7_IKZF2_HUMAN:194:217_2kmk_A_1 2kmk 194-217 View model · PDB

Model-summary evidence imported for this region.

RankTemplateDomainN-tailsC-tailsChainsIdentity / similarityCoverageModel file
1 2i13 111:223 113 215 P:A · DNA:C,D 44.7% / 62.1% 68 View · PDB TFS_sp_Q9UKS7_IKZF2_HUMAN:113:215_2i13_A_1
5 5wjq 111:223 113 216 P:D · DNA:A,B 41.3% / 61.5% 36 View · PDB TFS_sp_Q9UKS7_IKZF2_HUMAN:113:216_5wjq_D_1
2 5ei9 111:223 114 215 P:E · DNA:A,B 41.2% / 57.8% 91 View · PDB TFS_sp_Q9UKS7_IKZF2_HUMAN:114:215_5ei9_E_1
3 5egb 111:223 114 215 P:A · DNA:C,D 41.2% / 57.8% 91 View · PDB TFS_sp_Q9UKS7_IKZF2_HUMAN:114:215_5egb_A_1
4 5eh2 111:223 114 215 P:F · DNA:C,D 41.2% / 57.8% 93 View · PDB TFS_sp_Q9UKS7_IKZF2_HUMAN:114:215_5eh2_F_1
1 1llm 111:223 166,166 219,219 P:C,D · DNA:A,B 38.9% / 55.6% 62,63 View · PDB DIMER_sp_Q9UKS7_IKZF2_HUMAN:166:219_1llm_C_1
Region 469-5184 models
Actions
Predicted = Low TFS_sp_Q9UKS7_IKZF2_HUMAN:469:518_5kkq_A_1 5kkq 469-518 View model · PDB
Predicted = Low TFS_sp_Q9UKS7_IKZF2_HUMAN:469:518_5t00_A_1 5t00 469-518 View model · PDB
Predicted = Low TFS_sp_Q9UKS7_IKZF2_HUMAN:469:518_5yeh_A_1 5yeh 469-518 View model · PDB
Predicted = Low TFS_sp_Q9UKS7_IKZF2_HUMAN:471:518_5k5h_A_1 5k5h 471-518 View model · PDB

View full model evidence table for rank, chains, N/C tails, coverage, RMSD-template information, identity/similarity, and linked model files.

Domains

Annotated protein domains. Overlaps with model-supported DNA-binding regions are shown when available.

ResiduesPFAMDomainUsed by prediction region?
140-162PF00096Zinc finger, C2H2 typeoverlaps 113-219
168-190PF00096Zinc finger, C2H2 typeoverlaps 113-219
196-219PF00096Zinc finger, C2H2 typeoverlaps 113-219